1/5. Leukaemia cutis presenting as leonine facies.Acute leukaemia may rarely present as diffuse papules, nodules and plaques forming leonine facies. Leukaemia cutis generally carries a poor prognosis, and responds less well to chemotherapy. We described a case of acute myelomonocytic leukaemia presenting as leonine facies as a result of extensive cutaneous infiltration. The patient did not achieve haematological remission following standard induction chemotherapy and succumbed 6 weeks after the diagnosis was made.- - - - - - - - - - ranking = 1keywords = prognosis (Clic here for more details about this article) |
2/5. Lupus erythematosus tumidus: an underestimated entity.There have been few reports of lupus erythematosus tumidus (LET) in the literature. Most of textbooks of dermatology or dermatopathology mention this entity only briefly, if at all. The authors describe an additional case of this underdiagnosed disorder that further supports its existence as a separate entity in the spectrum of the variants of chronic cutaneous lupus erythematosus. Although most cases are reported in the European countries, to our knowledge, this is the first case documented in portugal. The clinical, photobiological and histological features as well as differential diagnosis, treatment and prognosis are also discussed.- - - - - - - - - - ranking = 1keywords = prognosis (Clic here for more details about this article) |
3/5. Lymph node invasion by conidiobolus coronatus and its spore formation in vivo.Lymph node invasion with presence of conidia, their replicates, germ tubes, condidia with hair-like projections and hyphae have been observed in a case of entomophthoromycosis caused by conidiobolus coronatus. This rare occurrence of conidia with hair-like projections that is usually observed in vitro, has been observed in vivo, in the content of an abscess produced by this agent, C. coronatus in the present case. Severe disfigurement and destruction of facial and nasopharyngeal tissues, have also been observed in this case. Response to therapy with oral KI, surgery, combinations of trimethoprim and sulphamethoxazole and steroids though found useful initially, was ineffective subsequently as the disease progressed over 7 years. Findings of lymphatic invasion and the extensive destruction observed in the present case warrants a guarded prognosis. Free conidial reproduction found in lymph nodes may suggest the possibility of this disease being infectious, requiring an active and vigorous treatment schedule and control measures in this infection.- - - - - - - - - - ranking = 1keywords = prognosis (Clic here for more details about this article) |
4/5. Facial keratoacanthoma.The keratoacanthoma is a common tumor of hair follicle origin that appears predominantly on sun-exposed skin of elderly persons. Approximately 80% of the tumors arise on the face. It is characterized by the rapid growth of a painless, dome-shaped, 10 to 25 mm solitary lesion with a central keratinous plug that undergoes spontaneous involution over 6 to 12 months, leaving behind a puckered scar. Alarming growth and early histologic appearance (pseudocarcinomatous infiltration, cell atypicality, mitoses) are suggestive of squamous cell carcinoma, but biologic behavior and tumor architecture confirm its benign nature. However, evidence that all keratoacanthomas regress is lacking, malignant transformation has been reported, and less than excisional biopsy may render a difficult histologic diagnosis either inconclusive or erroneous, even in expert hands. Excisional biopsy is recommended as expedient and definitive management that offers optimal prognosis. Local flap or full-thickness graft closure affords cosmetic results that are superior to those provided by other treatment methods.- - - - - - - - - - ranking = 1keywords = prognosis (Clic here for more details about this article) |
5/5. scleromyxedema (papular mucinosis): a surgical perspective.scleromyxedema (papular mucinosis) is a rare systemic disorder with a poor prognosis that produces severe aesthetic and functional disability. A patient is presented for whom the hitherto undescribed use of aggressive surgical intervention for palliation is applied. methods are described, including a discussion of the trial-and-error evolution of the treatment. Results are shown that suggest that there is a place for surgical intervention in the treatment of the cutaneous changes produced by this disease.- - - - - - - - - - ranking = 1keywords = prognosis (Clic here for more details about this article) |