11/17. Lymphocytic meningoradiculitis (Garin-Bujadoux Bannwarth): from syndrome to disease?In two children with lymphocytic meningoradiculitis (Bannwarth's syndrome), IgG and IgM antibodies to borrelia burgdorferi were demonstrated. Clinical and laboratory parameters of the syndrome are described and recent bacteriological and serological findings that link the syndrome to the American lyme disease are discussed, as well as the effects of antibiotic treatment.- - - - - - - - - - ranking = 1keywords = burgdorferi (Clic here for more details about this article) |
12/17. polymerase chain reaction amplification of herpes simplex viral dna from the geniculate ganglion of a patient with Bell's palsy.Bell's palsy is the most common cause of facial paralysis. In this study, we demonstrate the presence of herpes simplex viral type 1 (HSV-1) genomic dna in the geniculate ganglion of a patient who had Bell's palsy. This association suggests that in this patient, HSV-1 may have caused Bell's palsy. If HSV-1 is a cause of Bell's palsy, treatment with acyclovir may be beneficial. Additional studies should be done to establish the prevalence of HSV-1 as an etiologic agent of Bell's palsy.- - - - - - - - - - ranking = 0.25150294695939keywords = lyme (Clic here for more details about this article) |
13/17. Acute Lyme neuropathy presenting with polyradicular pain, abdominal protrusion, and cranial neuropathy.A 53-year-old man developed multifocal radicular pain. The diagnosis of lyme neuroborreliosis was delayed until bifacial paresis and right lower abdominal wall weakness developed, prompting further evaluation. cerebrospinal fluid (CSF) examination showed aseptic meningitis. antibodies directed against borrelia burgdorferi were present in the serum; higher titers were present in the CSF, indicating local antibody production. Electrophysiologic studies showed both an axonal polyradiculopathy as well as demyelinative facial palsy. ceftriaxone therapy led to marked improvement in pain and facial palsies.- - - - - - - - - - ranking = 1keywords = burgdorferi (Clic here for more details about this article) |
14/17. Reinfection in Lyme borreliosis.Two patients with reinfection of borrelia burgdorferi are presented. An 11-year-old girl developed recurrent acute peripheral facial palsy at an interval of five years. A 64-year-old woman showed paraesthesia in the leg and effusion in the knee. Three years later, an erythema migrans developed at the thigh. In both patients tick bites, corresponding clinical manifestations, and detection of specific antibodies proved the reinfections. The course of the humoral immune responses showed basic differences between the patients. At the interval between the first and second infection, the specific antibodies of the girl decreased beyond the cut-off level. On the other hand, the titer of specific IgG antibodies of the other patient remained at a constant level. Reasons for the failure of immune protection are discussed.- - - - - - - - - - ranking = 1keywords = burgdorferi (Clic here for more details about this article) |
15/17. lyme disease with facial nerve palsy: rapid diagnosis using a nested polymerase chain reaction-restriction fragment length polymorphism analysis.A 64-year-old woman with lyme disease and manifesting facial nerve palsy had been bitten by a tick on the left frontal scalp 4 weeks previously. erythema migrans appeared on the left forehead, accompanied by left facial paralysis. Nested polymerase chain reaction-restriction fragment length polymorphism analysis (nested PCR-RFLP) was performed on dna extracted from a skin biopsy of the erythema on the left forehead. Borrelia flagellin gene dna was detected and its RFLP pattern indicated that the organism was B. garinii, Five weeks later, B. garinii was isolated by conventional culture from the erythematous skin lesion, but not from the cerebrospinal fluid. After treatment with ceftriaxone intravenously for 10 days and oral administration of minocycline for 7 days, both the erythema and facial nerve palsy improved significantly. Nested PCR and culture taken after the lesion subsided, using skin samples obtained from a site adjacent to the original biopsy, were both negative. We suggest that nested PCR-RFLP analysis might be useful for the rapid diagnosis of lyme disease and for evaluating therapy.- - - - - - - - - - ranking = 0.31437868369923keywords = lyme (Clic here for more details about this article) |
16/17. Recurrent varicella-zoster virus retinitis in a patient treated with systemic corticosteroids.A case of recurrent unilateral varicella-zoster virus (VZV) retinitis is reported. The retinitis was characterized by arteriolitis and retinal necrosis with secondary chorioretinal atrophy localized in the periphery of the supratemporal quadrant of the retina. polymerase chain reaction analysis of aqueous humor demonstrated VZV dna in both the initial and recurrent episode. The Goldmann-Witmer coefficient for VZV IgG was elevated. The initial VZV retinitis was successfully treated with acyclovir and corticosteroids. Three years later, high-dose corticosteroids alone were used to treat idiopathic facial nerve palsy. One month after concluding corticosteroids therapy, the VZV retinitis recurred in the same eye, suggesting that administration of the high-dose corticosteroids caused VZV reactivation and induced recurrence of VZV retinitis.- - - - - - - - - - ranking = 0.062875736739847keywords = lyme (Clic here for more details about this article) |
17/17. Delayed facial palsy following uneventful middle ear surgery: a herpes simplex virus type 1 reactivation?In rare cases, a facial palsy appears a few days after uneventful middle ear surgery. The reason for this delayed palsy is unclear. One hypothesis is that it results from a reactivation of herpes simplex virus type 1 (HSV-1) in the geniculate ganglion of the facial nerve. From 1987 to 1996, in the course of over 1,800 middle ear operations, we observed 7 ipsilateral delayed facial palsies and investigated 5 of them using immunologic and virologic methods, including the polymerase chain reaction (PCR). We could detect HSV-1 genome with the nested primer PCR in the tongue swabs of 4 of the 5 examined patients with delayed facial palsy. The immunologic changes in these palsies are also compatible with a reactivation of HSV-1. We conclude that minimal stimulation of the facial nerve during middle ear surgery could result in a reactivation of HSV-1 in the geniculate ganglion, which may in turn lead to a facial palsy.- - - - - - - - - - ranking = 0.062875736739847keywords = lyme (Clic here for more details about this article) |
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