Cases reported "Favism"

Filter by keywords:



Filtering documents. Please wait...

1/7. Hemolytic crisis after excessive ingestion of fava beans in a male infant with G6PD Canton.

    After ingesting fava beans, a 26-month-old Chinese-Japanese male infant showed a sickly complexion and yellowish-brownish skin and was hospitalized. Severe hemolytic anemia was observed on admission, and transfusion of 200 ml of packed red cells was required. Red cell enzyme assay revealed that the patient and the mother were deficient in glucose-6-phosphate dehydrogenase (G6PD). Subsequent molecular analysis showed that the patient had a missense mutation 1376 G to T (G6PD Canton) and his mother was a homozygote for the mutation. The patient was a son of a Chinese (Taiwanese) mother and a Japanese father. Although G6PD deficiency is rare in the original Japanese population, the number of "imported" cases could be rising rapidly. This is the first reported Japanese case of G6PD deficiency with G6PD Canton.
- - - - - - - - - -
ranking = 1
keywords = bean
(Clic here for more details about this article)

2/7. Glucose 6-phosphate dehydrogenase variants: Gd ( ) Alexandra associated with neonatal jaundice and Gd (-) Camperdown in a young man with lamellar cataracts.

    Two male subjects are described, with unusual clinical presentations and with hitherto undescribed G6PD variants. The first, of Italian extraction, suffered from severe neonatal jaundice following maternal ingestion of fresh broad beans (vicia fava) both prenatally and postnatally: the expression of the enzymatic defect was much more severe in the neonatal period than on retesting in adolescence, when biochemical characterization showed unique features which justify designation as a new variant Gd( ) Alexandra. The second patient, a boy of Maltese extraction who was found to have bilateral lamellar cataracts at the age of 4 years, was identified as G6PD deficient only as a result of a survey of children of Mediterranean origin with unexplained cataract formation; he has approximately 15% of normal enzyme activity, with another unique combination of biochemical characteristics which has led to its designation as Gd(-) Camperdown. Although this association may be coincidental, it prompts further attention to the possibility that under certain circumstances G6PD deficiency may favor cataract formation. The two cases illustrate the value of characterization of the mutant enzyme whenever unexpected clinical or laboratory results are obtained.
- - - - - - - - - -
ranking = 0.2
keywords = bean
(Clic here for more details about this article)

3/7. glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern italy: a case of G6PD A(-) associated with favism.

    During a routine screening for G6PD deficiency in the Province of Matera (Southern italy), an eleven-year-old boy was brought to our attention who had fever obviously caused by a viral infection, but who also had hepatosplenomegaly and haemoglobinuria. The boy had previously experienced two severe haemolytic attacks. At the age of six months severe haemolysis occurred after the ingestion of cooked fava beans. At the age of seven years, the haemolytic episode was very likely triggered by oral administration of co-trimoxazole. The G6PD activity level in erythrocyte lysate was clearly defective (25% of normal). The electrophoretic mobility of G6PD was 110% of normal. These data together with those obtained from biochemical and molecular characterisation allowed the variant to be identified as G6PD A(-). This is the first report of an association between the African type G6PD deficiency variant and favism.
- - - - - - - - - -
ranking = 0.2
keywords = bean
(Clic here for more details about this article)

4/7. Vitreoretinal hemorrhages after ingestion of fava beans in a G-6-PD-deficient subject.

    A case of vitreo retinal hemorrhages following a hemolytic crisis by fava beans in a G-6-DP-deficient patient is reported. Intravascular coagulation due to thromboplastin-like substances liberated by the diseased RBC could be the cause. The possibility of vitreoretinal hemorrhages of this nature in young subjects from the areas where G-6-PD deficiency is endemic is stressed.
- - - - - - - - - -
ranking = 1
keywords = bean
(Clic here for more details about this article)

5/7. Gd(-) Muret and gd(-) Colomiers, two new variants of glucose-6-phosphate dehydrogenase associated with favism.

    Two males subjects are described with hitherto undescribed glucose-6-phosphate dehydrogenase (G6PD) variants. The first is of French ancestry, the second of Sicilian extraction. Each subject suffered from acute hemolytic anemia following ingestion of broad beans (vicia fava). In both cases the hemolytic crisis occurred in a late period of life (29 and 58 years). No previous hemolytic crisis was recorded. The electrophoretic and kinetic properties of the mutant enzymes examined after purification from the red cells allowed each to be distinguished from other G6PD variants reported until now. The first variant was named Gd(-) Muret, the other Gd(-) Colomiers.
- - - - - - - - - -
ranking = 0.2
keywords = bean
(Clic here for more details about this article)

6/7. favism in a female newborn infant whose mother ingested fava beans before delivery.

    We describe a case of favism in a female newborn infant with glucose-6-phosphate dehydrogenase (G6PD) deficiency whose mother had ingested fava beans 5 days before delivery. At birth there were clinical and hematologic signs of hemolytic anemia, hemoglobinuria, and no blood group immunization. Study of the G6PD activity and 2-deoxy-glucose-6-phosphate utilization rate revealed that the infant and the mother were heterozygous for G6PD deficiency.
- - - - - - - - - -
ranking = 1
keywords = bean
(Clic here for more details about this article)

7/7. favism by proxy in nursing glucose-6-phosphate dehydrogenase-deficient neonates.

    Two nursing neonates deficient in glucose-6-phosphate dehydrogenase developed severe hyperbilirubinemia despite phototherapy. mothers of both the infants had recently eaten fava beans. The hemolytic triggers found in fava beans may have been absorbed by the mothers and excreted in their breast milk. carboxyhemoglobin determination performed on one of the infants reflected ongoing hemolysis.
- - - - - - - - - -
ranking = 0.4
keywords = bean
(Clic here for more details about this article)


Leave a message about 'Favism'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.