Cases reported "Fetal Resorption"

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1/2. Nonoperative management of ectopic pregnancy. A preliminary report.

    The incidence of ectopic pregnancy is increasing throughout the western world; at present it is uncertain how much of this increase is due to the disease and/or its antecedents and how much due to better means of diagnosis. That the treatment of the obvious or ruptured ectopic pregnancy should be surgical is beyond doubt. However, in view of the natural tendency of some ectopic pregnancies to terminate in tubal abortion or complete resorption, it is questionable whether surgery is always necessary in every early case or whether some patients can be monitored by means of rising or falling levels of beta subunits of human chorionic gonadotropin (HCG) until tubal abortion or resorption occurs. This may be the best means of preserving tubal function and fertility.
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keywords = resorption
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2/2. Induction of experimental antiphospholipid syndrome in naive mice with purified IgG antiphosphatidylserine antibodies.

    OBJECTIVE. It is accepted that antiphospholipid syndrome (APS) is due to the presence of anticardiolipin antibodies (aCL). Since phosphatidylserine is a negatively charged phospholipid, we tried to demonstrate the pathogenic role of antiphosphatidylserine in APS. methods. We used affinity purified IgG antiphosphatidylserine antibodies from sera of 2 patients with APS characterized by recurrent thromboembolic phenomena, recurrent fetal loss and prolonged activated partial thromboplastin time (aPTT). In one patient the antiphosphatidylserine Abs were the main antiphospholipid antibody (aPL) while the 2nd patient also had pathogenic aCL. The purified antibodies were passively infused into the tail vein of mice. The mice were mated and we followed them for manifestations of APS. RESULTS. Passive infusion of IgG but not IgM antiphosphatidylserine antibodies to pregnant ICR mice resulted in increased fetal resorption rate (40%), lower mean weights of the placentae and fetuses and prolonged aPTT (82 s). Antiphosphatidylserine antibodies were detected in the placentae. CONCLUSIONS. Our results point to the pathogenic role of antiphosphatidylserine antibodies and emphasize the importance of looking for the presence of antiphosphatidylserine Abs in sera of patients with clinical manifestations compatible with APS even in the absence of aCL Abs.
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ranking = 6575.2882767125
keywords = fetal resorption, resorption
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