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1/4. Diabetic mastopathy in type II diabetes mellitus.

    Diabetic mastopathy can mimic cancer. We report 2 cases of diabetic mastopathy in patients with long-standing type II diabetes. One was insulin-dependent, and the other had never been treated with insulin. These 2 patients had classical acoustical shadow on ultrasonograms. breast core biopsies showed constellations of morphological features resembling diabetic mastopathy, including sclerotic changes of the fibrous stroma with keloid-like collagen fibers, few epithelioid fibroblasts, perivascular and interlobular mononuclear cell infiltrates, and focal atrophic changes of the ductal-lobular units. Both patients were free of malignancy at 3 and 4 years of follow-up, respectively. There are limited data on diabetic mastopathy in insulin-naive type II diabetes mellitus patients. Better awareness of this entity and its sonographic features may allow more patients to be spared from excisional biopsy.
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keywords = diabetic
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2/4. Diabetic fibrous mastopathy: sonographic-pathologic correlation.

    Fibrous and inflammatory lesions of the breast in patients with early-onset, longstanding insulin-dependent diabetes mellitus (IDDM) can lead to misdiagnosis because the clinical, mammographic, and sonographic findings simulate breast cancer. We report a case of diabetic fibrous mastopathy with suspicious clinical, imaging, and cytologic findings.
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keywords = diabetic
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3/4. An uncommon case of diabetic mastopathy in type II non-insulin dependent diabetes mellitus.

    Diabetic mastopathy is an uncommon tumor-like proliferation of fibrous tissue of the breast that usually occurs in a patient who has suffered from type I diabetes mellitus of long duration. Here we report a rare case of diabetic mastopathy that occurred in type II non-insulin dependent diabetes mellitus. This patient was a 63-year-old postmenopausal woman. mammography, ultrasonography and MR imaging could not distinguish it from breast cancer. Although the core needle biopsy specimen showed fibrosis without evidence of malignancy, excisional biopsy was performed. Histological findings demonstrated typical diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. These lymphocytes were composed predominantly of B-cells. Five months after surgical biopsy, a nodular formation approximately 4 cm in diameter recurred adjacent to the resected end of the biopsy.
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keywords = diabetic
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4/4. Fibrous mastopathy in insulin dependent diabetics.

    The cases of two poorly controlled insulin dependent diabetic women, presenting with hard discrete breast lumps clinically suspicious of carcinoma are presented. mammography revealed dense dysplastic parenchymal changes with no specific features of carcinoma and ultrasound showed acoustic shadowing but no discrete mass. Excision biopsy of these lumps was performed. Histologically they were benign, and were composed of fibrous tissue with a chronic inflammatory cell infiltrate. With better awareness of fibrous mastopathy which can occur in this group of diabetic patients, and with the absence of specific radiological features of malignancy, some of these women may be observed and spared excision biopsy.
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keywords = diabetic
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