Cases reported "Flaviviridae Infections"

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1/2. A study on pathogenicity of hepatitis G virus.

    AIM: To study the pathogenicity of hepatitis G virus (HGV) and observe the genesis and pathological process of hepatitis G. methods: HGV-rna in serum was detected by RT-PCR assay. The immunohistochemical assays of liver tissue were performed with HGV monocoloned antibody (McAb) expressed from the region of HGV NS5 nucleic acid sequence. The clinical and pathological data of 52 patients with hepatitis G were discussed. In animal experiment, the Chinese Rhesus monkeys were infected with the serum of a patient with HGV infection. And the dynamic changes in serology and liver histology of animals were observed. RESULTS: One hundred and fifty-four patients with HGV-rna positive were selected from 1552 patients with various kinds of hepatitis. Of 154 patients with HGV infection, 52 were infected with HGV only, which accounted for 33.8 (52/154) and 102 with positive HGV-rna were super-infected with other hepatitis viruses, which accounted for 66.2 (102/154). The clinical and pathological observation showed that the acute and chronic hepatitis could be induced by HGV. The slight abnormality of transaminases ALT and AST in serum of monkeys lasted nearly 12 months and histological results showed a series of pathological changes. CONCLUSION: HGV is a hepatotropic virus and has pathogenicty. ( info)

2/2. Human disease caused by an arbovirus closely related to Ilheus virus: report of five cases.

    We report five cases of human disease caused by arbovirus in 5 patients from the State of Sao Paulo, brazil, residing in the municipalities of Osasco, Atibaia, Guaruja, and the capital Sao Paulo, respectively. One of the patients resides in Sao Luis, capital of the State of Maranhao. The sites of infection probably were the states of Parana and Goias, both in cave regions, the State of Amazonas, and Rondonia in two cases. Laboratory tests for malaria were negative and 1 patient showed a positive serum reaction for leptospirosis. serum samples from the acute and convalescent phases were tested by hemagglutination inhibition, complement fixation, and neutralization in mice. Acute phase samples were inoculated into suckling mice by the intracerebral route. A close antigenic relationship was observed between the five agents isolated and the flavivirus Ilheus. serologic tests demonstrated the absence of antibodies in all samples from the 5 patients during convalescence and even for more than 1 year after infection in 1 of them. ( info)

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