Cases reported "Genital Neoplasms, Female"

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1/3. Intestinal invasion by a dysgerminoma in a patient with Swyer syndrome.

    An unusual case is presented of advanced dysgerminoma in a patient with Swyer syndrome, 46,XY pure gonadal dysgenesis. Unexpected regional invasion necessitated bowel resection, total abdominal hysterectomy, and bilateral salpingogonadectomy for a complete en bloc excision of the primary tumor mass and the dysgenetic gonads. This report illustrates the possible need for extensive operative resection in patients with Swyer syndrome.
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keywords = dysgerminoma
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2/3. Malignant teratoma arising in a dysgenetic gonad.

    A case of malignant teratoma arising within a dysgenetic gonad in a 21-year-old phenotypic female with a 46 XY karyotype is presented. Admixtures of dysgerminoma, yolk sac tumor in close juxtaposition to embryoid bodies and elements of choriocarcinoma were also present. The contralateral gonad was an unidentifiable fibrovascular streak. Neither gonadoblastoma nor coarse calcifications (such as commonly found in gonadoblastoma) could be identified. We believe that the present case arose de novo in a dysgenetic gonad and, uncharacteristically, was not associated with a gonadoblastoma.
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3/3. Five different histological subtypes of germ cell malignancies in an XY female.

    A case of a 19-year-old female with 46 XY gonadal dysgenesis and five different histological subtypes of germ cell malignancies is described. Both adnexa were removed, preserving the uterus. pathology revealed gonadoblastoma with dysgerminoma differentiation present in both gonads and in the left gonad mature teratoma, embryonal carcinoma, and endodermal sinus tumor were identified as well. She received no adjuvant treatment and has remained well 30 months after diagnosis.
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