Cases reported "Granulosa Cell Tumor"

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1/11. Ovarian sex cord tumor with annular tubules.

    A pathologic study was done on four cases of ovarian sex cord tumor with annular tubules. All four tumors occurred in young women (11-24 years of age) and were not associated with the peutz-jeghers syndrome. Two patients had evidence of hyperestrinism. One patient who had metastasis to the retroperitoneum, left supraclavicular lymph node, and liver confirmed the malignant potential of this tumor. Gross examination revealed tumors that were solid, yellowish, and unilateral, with varying degrees of cystic degeneration. Microscopic examination showed simple or complex annular tubules with prominent basement membranes. Many tumor cells contained lipid in the cytoplasm. Ultrastructural study showed Charcot-Bottcher filaments in all four cases, indicating Sertoli cell differentiation. True lumens and microvilli were identified in one case. The classification of the sex cord tumor with annular tubules as a sertoli cell tumor, annular tubular type was proposed on the basis of ultrastructural findings.
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2/11. Pelvic neoplasia in peutz-jeghers syndrome.

    A cervical adenocarcinoma, a left ovarian granulosa cell tumor, and a right ovarian sex cord tumor with annular tubules developed in a woman with peutz-jeghers syndrome. This apparent first report of three different pelvic tumors occurring in a patient with Peutz-Jeghers polyposis suggests a possible link between pelvic tumors and the peutz-jeghers syndrome.
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3/11. Juvenile granulosa cell tumor of the testis.

    Juvenile granulosa cell tumor occurred in a newborn. The tumor presented with testicular torsion, and no malformations were observed. The karyotype was normal. The occurrence of initial tumoral lesions in the seminiferous tubules located in the vicinity of the tumor suggests that the tumor originated from immature Sertoli's cells. To our knowledge, this is the tenth case reported in a newborn and the second associated with testicular torsion.
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4/11. Fine needle aspiration cytology of ovarian sex cord tumor with annular tubules.

    The clinical and cytopathologic features of a case of ovarian sex cord tumor with annular tubules are presented. To the best of our knowledge, this is the first report describing the cytologic features in a fine needle aspirate. Aspiration cytology cannot distinguish this tumor with certainty from a granulosa-cell tumor.
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5/11. Does ovarian sex cord tumour with annular tubules produce progesterone?

    Probable progesterone production was identified by an immunoperoxidase assay in a case of an ovarian sex cord tumour with annular tubules. The tumour was associated with a serous cystadenofibroma in the opposite ovary and with adenoma malignum (adenocarcinoma) of the cervix.
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6/11. Metastatic granulosa cell tumor with pattern of sex cord tumor with annular tubules.

    A case of malignant, complex sex cord tumor with multiple differentiations in a 38-year-old woman is presented. The neoplasm presented originally as a pure granulosa cell tumor, and in the second look operation as a sex cord tumor with annular tubules (SCTAT). Six years later abdominal metastases revealed a mixed pattern of granulosa and sertoli cell tumor admixed with SCTAT. The patient died despite chemotherapy. Analysis of the 10 previously reported cases of malignant SCTAT shows that tumor size is the main prognostic indicator. Mitoses, atypia, and stromal invasion seem also to bear prognostic implications when present. The association of both granulosa and sertoli cells with SCTAT seems to provide a clue for SCTAT being a peculiar intermediate phenotypical expression of pluripotential stem sex cord cells of the gonads.
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7/11. Ovarian sex cord tumors with annular tubules: an ultrastructural study.

    The ultrastructural features of two "sex cord tumors with annular tubules" are presented. The findings are compared with the reported fine structure of ovarian and testicular stromal cells and the cells of gonadal stromal neoplasms. The predominant cell in the "sex cord tumor with annular tubules" has some of the ultrastructural features found in gonadal stromal cells of either ovarian or testicular type; however, no Charcot-Bottcher crystals, lamellar bodies, crystalloids of Reinke, abundant smooth endoplasmic reticulum or complex plasma membrane interdigitations are observed in the tumor cells to suggest wither Sertoli or Leydig cell origin. The striking similarity between the predominant cell type and granulosa cells, as well as the presence of fibrillary material of the type seen in Call-Exner bodies, suggests a granulosa cell origin for these neoplasms. However, the presence of a sparsely distributed second cell type which closely resembles the dark cells in normal nonluteinized ovarian stroma indicates these tumors may arise from the nonspecialized ovarian stroma.
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8/11. Ovarian stromal tumors with minor sex cord elements: a report of seven cases.

    Seven ovarian tumors that were predominantly stromal, but contained, in addition, a minor component of sex cord elements, were encountered in patients ranging from 16 to 65 years of age. The tumors varied from 1 to 10 cm in diameter and resembled grossly fibromas or thecomas. On microscopical examination they were predominantly fibromatous, but also contained small nests or tubules composed of cells resembling granulosa cells, sertoli cells, or indifferent cells of sex cord type. Two tumors also had cells of steroid-hormone-cell type; these cells contained crystalloids of Reinke in one case. These two tumors were classified as luteinized thecoma and stromal-leydig cell tumor with minor sex cord elements. The other five tumors were designated fibromas with minor sex cord elements. Five-year follow-up, available in three cases, revealed no evidence of recurrence after operative removal. Although the presence of sex cord components has generally resulted in the classification of an ovarian tumor in either the granulosa cell or Sertoli-Leydig cell category, we propose that tumors with only minor sex cord components be placed in a separate category.
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9/11. peutz-jeghers syndrome and cancer.

    A 27-year-old white woman with peutz-jeghers syndrome (PJS) associated with a rare but distinctive ovarian tumor, the sex cord tumor with annular tubules (SCTAT), is discussed. Pertinent oral manifestations of PJS and chemotherapy complications are illustrated by the case report. Traditionally, patients exhibiting PJS have not been considered at increased risk of cancer development. This case, coupled with a review of the recent literature, suggests that these patients are, indeed, at increased risk of malignant lesions of several organ systems.
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keywords = tubule
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10/11. Ovarian sex cord tumors with annular tubules. An ultrastructural study of three cases.

    The ultrastructural features of three ovarian sex cord tumors with annular tubules were analyzed. The cells had deeply indented nuclei, interdigitating plasma membranes joined by abundant desmosomes, and numerous randomly distributed microfilaments that often complexed with desmosomes. Charcot-Bottchner crystalloids were absent. None of the tubular structures had true lumens. The characteristic central hyaline bodies resembled some forms of Call-Exner bodies and were composed of concentric layers of basal lamina, which often were continuous with redundant basal lamina of the peripheral basement membrane. Because of the clinical, histologic, and ultrastructural similarities to granulosa cell tumors and normal preovulatory granulosa cells, classification of the sex cord tumor with annular tubules is proposed as a distinctive annular and membranous variant of granulosa cell tumor.
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