1/5. gynecomastia with sulpiride.OBJECTIVE: Neuroleptic agents have been associated with gynecomastia, but evidence for a causal link is insufficient. We describe a case of unilateral gynecomastia without galactorrhea in a 38-year-old man during sulpiride treatment for generalized anxiety disorder. The patient had been treated with sulpiride (100 mg/day) for about 5 months by a primary care physician. In this patient, no specific endocrine alterations were found, except for a marked increase in prolactin (PRL) level and slight decrease in testosterone (T)/estradiol (E2) ratio. Drug withdrawal led to a reduction of the lump. sulpiride is a substituted benzamide with selective dopaminergic blocking activity. From the marked increase in PRL level and the slight decrease in T/E2 ratio observed during sulpiride therapy, it is proposed that sulpiride may induce gynecomastia by inhibiting hypothalamic-pituitary function directly, and/or indirectly through hyperPRLemia.- - - - - - - - - - ranking = 1keywords = galactorrhea (Clic here for more details about this article) |
2/5. galactorrhea in a 12-year-old boy with a chromophobe adenoma.A 12-year-old with galactorrhea is presented. He was in early puberty, had gynecomastia, and was markedly obese. Roentgenograms of the skull showed an asymmetrically enlarged sella trucica, but pneumoencephalography did not indicate suprasellar extension of the pituitary tumor. Preoperative studies of anterior pituitary function were normal except for persistent hyperprolactinemia. By transsphenoidal approach, a microadenoma of the pituitary was removed. lactation ceased within a week, and four months postoperatively the patient had normal anterior pituitary function studies. A review of the literature indicates that galactorrhea in males is very rare. The most frequently documented cause, excluding drug ingestion, is a pituitary tumor.- - - - - - - - - - ranking = 2keywords = galactorrhea (Clic here for more details about this article) |
3/5. Benign galactorrhea/breast discharge in adolescent males probably due to breast self-manipulation.Three adolescent males presented with nipple discharge. In two boys, the expressed secretion was clinically consistent with galactorrhea. galactorrhea/breast discharge is a rare complaint in males of any age. Although galactorrhea is commonly associated with a neuroendocrine disorder or drug ingestion, the work-up in each, including basal prolactin level, was normal. Reluctantly, each by admitted to breast self-manipulation to reduce gynecomastia. When the behavior was discontinued, the galactorrhea/breast secretion ceased. Clinicians should be aware of this heretofore undescribed and apparently benign phenomenon. If basal hyperprolactinemia is absent in a male with a breast discharge and a history of breast manipulation, then an extensive work-up is not usually indicated.- - - - - - - - - - ranking = 7keywords = galactorrhea (Clic here for more details about this article) |
4/5. Idiopathic hyperprolactinemia in a 15-year-old boy: a case report and literature review.A 15-year-old boy with idiopathic hyperprolactinemia is described. He was markedly obese, in early puberty, and had gynecomastia and galactorrhea. serum prolactin level was high, up to 220 pg/ml. Thyroid function test was normal. Idiopathic hyperprolactinemia was diagnosed on the basis of elevated prolactin level, and no demonstrable pituitary tumor was revealed by computerized tomography brain scan and magnetic resonance imaging. bromocriptine was started initially at the dose 2.5 mg/day, then increased to 7.5 mg/day. galactorrhea disappeared and prolactin level decreased to < 10 ng/ml. A review of the literature indicates that idiopathic hyperprolactinemia in adolescent males is extremely rare. To our knowledge, this patient is the youngest reported case of hyperprolactinemia in thailand.- - - - - - - - - - ranking = 1keywords = galactorrhea (Clic here for more details about this article) |
5/5. gynecomastia with metoclopramide use in pediatric patients.gynecomastia and galactorrhea stemming from hyperprolactinemia have been reported in adults after the use of metoclopramide. We describe the cases of an adolescent with gynecomastia and an infant with gynecomastia and galactorrhea that were the result of metoclopramide therapy for gastroesophageal reflux disease.- - - - - - - - - - ranking = 2keywords = galactorrhea (Clic here for more details about this article) |