Cases reported "Htlv-Ii Infections"

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11/22. A new HTLV type II subtype A isolate in an HIV type 1-infected prostitute from cameroon, Central africa.

    Among 332 female sex workers in Douala, cameroon, 113 were hiv-1 seropositive, 3 were HTLV-I seropositive, and only 1 had specific anti-htlv-ii antibodies. By cocultivation with BJAB cells, an HTLV-II was isolated from the peripheral blood mononuclear cells of this 32-year-old woman coinfected by hiv-1. This new African HTLV-II isolate (PH230PCAM) belongs to the molecular subtype A, exhibiting, however, a nucleotide variability of 2.4% and 0.8%, vis-a-vis the MO prototype, in the LTR and in the gp21 env gene, respectively. These data, as well as the previous findings of another HTLV-II subtype A in a Ghanean prostitute, suggest that this viral subtype had been imported into africa, while the HTLV-II subtype B, described in remote areas of Zaire, gabon, and cameroon, could be a genuine African HTLV-II, present in this continent for a long period of time. ( info)

12/22. Isolation and genomic analysis of human T lymphotropic virus type II from ghana.

    An HTLV-II was isolated from a Ghanaian female patient with ARC and anti-HTLV-II antibody by cocultivation of PBMC with Molt-4 cells. A part of the 5' LTR of this virus was sequenced. sequence homology between this virus and the corresponding sequence of Mo, the prototype of HTLV-II, is 97.4%. Furthermore, this virus is a member of the HTLV-IIa group, which was proposed by Hall et al. This is the first report of an HTLV-II sequence from africa confirmed not only by serological evidence, but also by genomic analysis. This finding will provide useful information for considering the spread of HTLV-II in the world and the evolution of the HTLV group. ( info)

13/22. HTLV-I and -II in intravenous drug users from sweden and denmark.

    693 IVDU (intravenous drug user) sera from Copenhagen, Malmo and Stockholm were tested, 247 retro- and 446 prospectively, for antibodies to human T-lymphotropic virus (HTLV), types I and II, by means of a commercial whole-virus EIA and/or an HTLV-I/-II peptide-based EIA. Positive EIA reactions were checked and typed by electrophoretic immunoblotting, a differential peptide-based EIA and nucleic acid amplification/hybridization with HTLV-I and -II specific primers and probes. 3 (0.7%) of the prospectively tested IVDUs from Malmo, none of 100 from Stockholm and none of 45 from Copenhagen were HTLV-seropositive. The 3 Malmo IVDU cases were a female immigrant from south america, her male native Swedish spouse (both HTLV-I), and a male immigrant Italian heroinist (HTLV-II). We conclude that HTLV was uncommon among intravenous drug users, a sentinel population, in sweden and denmark during 1986 and 1989. However, the occurrence of 3 HTLV-positive cases in Malmo 1993 indicates that the situation can change rapidly. ( info)

14/22. Large granular lymphocytosis in a patient infected with HTLV-II.

    HTLV-II has been associated with a variety of lymphoproliferative disorders, including atypical hairy cell leukemia, chronic T cell leukemia, T prolymphocytic leukemia, and large granular lymphocytic leukemia. However, a direct or indirect role for HTLV-II in these disorders is not yet firmly established. We studied a patient diagnosed as having leukemia of the large granular lymphocyte (LGL) type who was HTLV-II seropositive, to determine if the expanded cell population was infected. Two populations of CD3-CD16 LGL were identified; one was CD8 , the other CD8-. Populations of cells with these surface markers as well as normal CD3 CD4 and CD3 CD8 cells were separated by flow cytometric methods, dna extracted, and gene regions of HTLV-II pol and tax amplified, using the polymerase chain reaction, and probed after Southern blotting. HTLV-II was detected in the CD3 CD8 population, and not in the CD3-CD16 large granular lymphocyte population. This finding indicates that the role of HTLV-II, if any, in LGL proliferation is indirect. ( info)

15/22. Progressive nemaline rod myopathy in a woman coinfected with hiv-1 and HTLV-2.

    Nemaline-rod myopathy was recently reported in eight young males infected with human immune deficiency virus type 1 (hiv-1). A 41-year-old woman had a 2-year history of progressive proximal-muscle weakness. Muscle biopsy demonstrated the presence of nemaline rods, predominantly in type 1 fibers. She was coinfected with hiv-1 and HTLV-2, as evidenced by positive polymerase chain reaction and serology. There was no lymphopenia or CD4 lymphopenia, despite an abnormal T-cell subset ratio, high CD8 count, skin anergy, and depressed in vitro response to mitogens. This case raises the possibility that dual infection may play a role in the pathogenesis of the rare nemaline-rod myopathies of HIV-infected patients. ( info)

16/22. Spastic ataxia associated with human T-cell lymphotropic virus type II infection.

    Human T-cell lymphotropic virus type one (HTLV-1) is associated with tropical spastic paraparesis or HTLV-I--associated myelopathy. We report 2 women with a spastic ataxic illness similar to HTLV-I--associated myelopathy infected solely with HTLV-II. Identification of HTLV-II infection was made serologically, by polymerase chain reaction, and by viral culture (in 1 woman). One woman, treated with 200 mg of danazol orally, three times daily, had pronounced improvement in ambulation, nocturnal spasticity, and nighttime urinary frequency. It appears that infection with HTLV-II may cause an illness similar to HTLV-I--associated myelopathy, but distinguished by the presence of ataxia. ( info)

17/22. Acute varicella hepatitis in human T-cell lymphotrophic virus types I and II infection.

    Varicella (chicken pox) is a common viral infection in children and generally runs a benign course. However, in adults, and especially in immunocompromised subjects such as those on immunosuppressant therapy or with AIDS, varicella infection is particularly severe and is associated with the formation of hemorrhagic skin lesions and visceral involvement. These patients are at an increased risk of developing varicella hepatitis, which frequently results in fulminant hepatic failure and death. In the present report, we describe for the first time the course of disease and the histological appearance of varicella hepatitis in a patient infected with the human T cell lymphotropic viruses (HTLV) I and II; these viruses have many characteristics in common with the human immunodeficiency virus (HIV). Our patient had a relatively benign illness, suggesting that varicella infection in the presence of HTLVI and II may not run as severe a course as it does in patients with HIV infection. ( info)

18/22. Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe.

    A longitudinal study, spanning 25 years and great demographic and cultural change, found a persistently high prevalence of human T-lymphotropic virus type II (HTLV-II) in the Xikrin Kayapo Indians of brazil. More than 10% of the children continue to develop immune reactions to the virus in infancy, a sharp increase in seroprevalence occurs between ages 15 and 30 years, and prevalence in older woman still approaches 100%. This suggests that the major modes of transmission (breast milk and sexual activity) have not changed. The demonstration of stable maintenance of HTLV-II in one ethnic group makes migration theories of its dispersal more plausible. However, the infection may not be a negligible burden on population survival: at least 1 of 62 persons followed until age 40 years died of possible tropical spastic paraparesis (TSP). ( info)

19/22. Human T-cell lymphotropic virus type II-associated myelopathy: clinical and immunologic profiles.

    Human T-cell lymphotropic virus type II (HTLV-II) is endemic in several ethnic tribes and among intravenous drug users in metropolitan areas. Despite the presence of HTLV-II in these various populations, the association of HTLV-II with disease is sparse and mainly limited to isolated case reports. This study is an extension of an earlier description of an HTLV-II-infected patient with neurologic disease and presents the clinical and immunologic findings of 4 patients with HTLV-II seropositivity and spastic paraparesis. The patients are of African-American origin with 3 of the patients being of Amerindian descent. All of the patients are seronegative for the human immunodeficiency virus (HIV). The patients progressed to a nonambulatory state in less than 5 years. magnetic resonance imaging studies obtained from 3 of the patients demonstrated white matter disease in the cerebrum and spinal cord. The cerebrospinal fluid and serum contained antibodies to HTLV-II. The presence of proviral HTLV-II was confirmed by polymerase chain reaction analysis of peripheral blood lymphocytes (PBLs). A spinal cord biopsy from 1 patient demonstrated HTLV rna within a lesion. Immunologic studies on 2 patients demonstrated that spontaneous lymphoproliferation of PBLs was present but decreased relative to HTLV-I-infected patients. The clinical and immunologic findings from these HTLV-II-infected patient resemble those found in HTLV-I-associated myelopathy/tropical spastic paraparesis. ( info)

20/22. Large granular lymphocyte leukaemia occurring after renal transplantation.

    Post-transplantation lymphoproliferative disorders (PTLD) are a clinicopathologically heterogeneous group of lymphoid proliferations. The majority are of B-cell origin and associated with Epstein-Barr virus (EBV) infection. In contrast, the development of T-cell PTLD is much less common and EBV does not appear to be involved in pathogenesis. In this report we describe three patients who developed large granular lymphocyte (LGL) leukaemia after renal transplantation. These patients had clonal expansion of CD3 , CD8 , CD57 , CD56- LGL. We were unable to detect CMV antigen or find evidence for EBV or human T-cell leukaemia/lymphoma virus genome in the LGL from these patients. These data show that LGL leukaemia should be included as one of the types of T-cell proliferations which can occur post transplant. ( info)
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