Cases reported "Heart Arrest"

Filter by keywords:



Filtering documents. Please wait...

11/33. Documented exercise-induced cardiac arrest in a paediatric patient with hypertrophic cardiomyopathy.

    A paediatric patient with hypertrophic cardiomyopathy (HCM) presented cardiac arrest due to ventricular fibrillation. Ventricular arrhythmias were not induced in an electrophysiological study, but an implantable cardioverter defibrillator (ICD) was implanted. Nine months later, the child experienced a recurrence of cardiac arrest during exercise, which was successfully treated with a defibrillator shock from the device. Analysis of the stored electrograms demonstrated ventricular fibrillation of abrupt onset following sinus tachycardia. The risk factors and the potential mechanism leading to recurrent cardiac arrest in this case are discussed. This report supports implantation of an ICD as a life-saving therapeutic approach not only for adults but also for children with HCM at high risk.
- - - - - - - - - -
ranking = 1
keywords = cardiomyopathy
(Clic here for more details about this article)

12/33. Undiagnosed phaeochromocytoma mimicking severe preeclampsia in a pregnant woman at term.

    We report an unusual case of phaeochromocytoma in pregnancy. The patient presented with severe hypertension, visual disturbances, proteinuria, glycosuria and pulmonary oedema at 38 weeks' gestation. The initial diagnosis was severe preeclampsia, but rapid deterioration of the fetus necessitated an emergency caesarean section under general anaesthesia, following which the maternal condition deteriorated rapidly. Differential diagnoses included pulmonary embolus, cardiomyopathy, amniotic fluid embolus and ischaemic/embolic cerebrovascular accident. Despite aggressive maximal treatment, mother and baby died 36 h later. Post mortem examination of the mother revealed a 5.5-cm tumour of the right adrenal gland confirmed histologically as a phaeochromocytoma. We examine the diagnostic dilemmas of this case and consider the treatment and management options when faced with a critically ill mother and the need to deliver her fetus by emergency caesarean section. We also question the clinical priorities during management of a sudden deterioration in both maternal and fetal health.
- - - - - - - - - -
ranking = 0.2
keywords = cardiomyopathy
(Clic here for more details about this article)

13/33. Arrhythmogenic right ventricular cardiomyopathy due to a novel plakophilin 2 mutation: wide spectrum of disease in mutation carriers within a family.

    BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial disease, with male preponderance, characterized by progressive fibrofatty replacement of the right ventricle and ventricular arrhythmias. Mutations in plakophilin-2 (PKP2), a desmosomal protein, have been reported to underlie familial ARVC. We report a novel ARVC PKP2 mutation and present the clinical findings in three female mutation carriers. methods: We sequenced PKP2 from genomic dna isolated from peripheral blood lymphocytes in a female proband who presented with cardiac arrest and in her four first-degree relatives. Clinical testing and diagnosis of ARVC was based on International Task Force criteria. RESULTS: The proband was diagnosed with ARVC due to right ventricular enlargement and regional hypokinesis, along with repolarization abnormalities and frequent ventricular ectopy. A novel 28 bp insertion in exon 11 of the PKP2 gene was found which causes a frameshift in the coding region. This results in a change in the amino acid sequence of the protein with a premature stop codon at position 740. Of the four relatives, only the mother and younger sister were identified as mutation carriers. The mother was phenotypically normal, while the younger sister has repolarization abnormalities and frequent ventricular ectopy. CONCLUSIONS: We report a novel PKP2 mutation that causes familial ARVC. All mutation carriers in this kindred group were women, and the family showed incomplete penetrance and variable expression of ARVC. Premature truncation of the plakophilin-2 protein appears to be the predominant mechanism whereby PKP2 mutations elicit the ARVC phenotype.
- - - - - - - - - -
ranking = 1
keywords = cardiomyopathy
(Clic here for more details about this article)

14/33. Reversible myocardial depression in survivors of cardiac arrest.

    Three patients under 40-years old who survived cardiac arrest due to ventricular fibrillation were originally diagnosed as having idiopathic dilated cardiomyopathy. Shortly after cardiac arrest, assessment of myocardial function revealed a globally dilated left ventricle in each patient with an estimated ejection fraction between 20% and 30%. Serial assessment of myocardial function, however, showed either normal or near-normal function by 2 weeks postevent. These findings suggest that myocardial stunning due to hypoperfusion during ventricular fibrillation or the effects of transthoracic shocks may result in profound, reversible myocardial depression in survivors of cardiac arrest. Serial evaluation of left ventricular function may be of value in selected survivors of cardiac arrest in order to evaluate time-dependent resolution of myocardial dysfunction and may prevent misdiagnosis of idiopathic dilated cardiomyopathy.
- - - - - - - - - -
ranking = 0.4
keywords = cardiomyopathy
(Clic here for more details about this article)

15/33. Incessant ectopic atrial tachycardia and sudden death.

    A patient with refractory and incessant ectopic atrial tachycardia (IEAT) is reported in whom it was possible to document, during ECG (Holter) the occurrence of aborted sudden death by spontaneous ventricular fibrillation (VF). Following the second of two attempts at surgical ablation of the origin of the IEAT, the patient has been asymptomatic without antiarrhythmic drugs and in sustained sinus rhythm for 24 months. Although we cannot exclude the residual action of amiodarone and flecainide (proarrhythmia) or the residual peripartum cardiomyopathy it is probable that the observed VF was a true complication of a cardiomyopathy induced by a chronically increased heart rate (HR). Although unclear, this VF might be considered as a form of adrenergic-dependent long qt syndrome due to early afterdepolarization in the presence of predisposing myocardial conditions.
- - - - - - - - - -
ranking = 0.4
keywords = cardiomyopathy
(Clic here for more details about this article)

16/33. Legal liability for injury to research subjects.

    In Weiss vs Solomon, the heirs of a subject who died while a volunteer in a nontherapeutic study successfully sued the investigator and his university-affiliated hospital. Without referring to any 'standard of practice', including the MRC Guidelines, the judge found the principal investigator and the hospital (for its research ethics committee) equivalently responsible for not disclosing a rare but fatal complication caused by fluorescein dye and not adequately screening the subject, who suffered from undisclosed hypertropic cardiomyopathy. From the point of view of research institutions, members of research committees, and the investigators themselves, the judgement has left serious uncertainty and ambiguity concerning their responsibilities for subject selection and safety, and disclosure for the purposes of informed consent.
- - - - - - - - - -
ranking = 0.2
keywords = cardiomyopathy
(Clic here for more details about this article)

17/33. Possible proarrhythmic effects of tocainide in dilated cardiomyopathy.

    A patient with a dilated cardiomyopathy experienced a cardiac arrest when taking tocainide for asymptomatic nonsustained ventricular tachycardia. After successful resuscitation from ventricular fibrillation and exclusion of a myocardial infarction, an electrophysiological evaluation was performed. Drug-free study #1 revealed no induction of ventricular tachycardia. A tocainide study revealed induction of sustained monomorphic ventricular tachycardia. Drug-free study #2 revealed induction of nonsustained ventricular tachycardia. This report illustrates a possible proarrhythmic effect of tocainide.
- - - - - - - - - -
ranking = 1
keywords = cardiomyopathy
(Clic here for more details about this article)

18/33. Sudden bradyarrhythmic death in dilated cardiomyopathy: a case report.

    An 18-year-old male presented with biventricular failure and atrial fibrillation. Detailed investigations revealed the diagnosis of dilated cardiomyopathy. He was put on medical treatment which resulted in symptomatic improvement. One year later he presented with 2 episodes of syncope, with no change in the routine electrocardiogram. A 24-hour ambulatory monitoring was done. The patient died suddenly while on the monitor. Analysis of the terminal event revealed a sudden complete heart block followed by asystole, an event described very rarely in the published literature.
- - - - - - - - - -
ranking = 1
keywords = cardiomyopathy
(Clic here for more details about this article)

19/33. Cardiac arrest in an adolescent with atrial fibrillation and hypertrophic cardiomyopathy.

    A 15 year old youth, who presented with out-of-hospital cardiac arrest due to documented ventricular fibrillation, was found to have nonobstructive hypertrophic cardiomyopathy. Electrophysiologic study demonstrated inducible sustained atrial fibrillation with a rapid ventricular response. This rhythm, associated with hypotension and evidence of myocardial ischemia, spontaneously degenerated into ventricular fibrillation. No ventricular arrhythmias were inducible by programmed ventricular stimulation. Therapy with metoprolol and verapamil slowed the ventricular rate during atrial fibrillation and maintained hemodynamic stability, both during follow-up electrophysiologic study and during a subsequent spontaneous episode.
- - - - - - - - - -
ranking = 1
keywords = cardiomyopathy
(Clic here for more details about this article)

20/33. Unsuspected amyloidosis and cardiac arrest following mitral valve replacement.

    We performed an autopsy on a 58-year-old female with previously unsuspected cardiac amyloidosis. One day prior to expiration the patient underwent a mitral valve replacement with a Bjork-Shiley prosthesis for mitral valve regurgitation. The valvular defect along with the massive myocardial amyloidosis which created a restrictive cardiomyopathy, were the etiology of the patient's poor cardiac output and subsequent demise.
- - - - - - - - - -
ranking = 0.2
keywords = cardiomyopathy
(Clic here for more details about this article)
<- Previous || Next ->


Leave a message about 'Heart Arrest'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.