Cases reported "Hemangiosarcoma"

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11/39. Angiosarcoma of the submandibular salivary gland: case report and review of the literature.

    OBJECTIVES: The purpose of this report is to describe an example of angiosarcoma (AS) of the submandibular salivary gland. The clinical and immunohistopathologic features of these lesions are also reviewed. MATERIAL AND methods: A 17-year-old male high school student was admitted to our clinic with a 1-year history of a slow-growing, tender mass in the left submandibular region. physical examination on initial presentation revealed a diffuse soft tissue mass 6 cm in diameter involving the left submandibular region. MRI analysis revealed a mass located superolateral to the submandibular salivary gland, measuring 4.0 x 2.0 cm2. The mass was excised completely together with the left submandibular salivary gland. Histopathologic analysis led to a diagnosis of AS. Immunohistochemical studies were also used to determine endothelial cell differentiation. Owing to the lateralized nature of the lesion, a left functional neck dissection was performed and postoperative radiotherapy was planned. RESULTS: AS is a malignant tumor of endothelial cell origin that may occur in any region of the body. The commonest sites include the extremities and the retroperitoneal space, with only 4% of AS tumors arising in the head and neck area. The submandibular salivary gland is an extremely rare location for this tumor. Based on a literature review, this case report represents only the second reported case of AS of the submandibular salivary gland. CONCLUSIONS: In most cases, radical surgery and postoperative radiotherapy are advocated to treat patients with AS tumors, with lymph node clearance recommended in cases of lateralized lesions In some patients, distant metastasis may occur after many years, which necessitates long-term follow-up. The prognosis is poor in most cases of AS.
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12/39. Primary angiosarcoma of the parotid gland arising from benign congenital hemangioma.

    A case of malignant transformation of a benign congenital hemangioma of the parotid gland is presented. The malignant tumor occurred in a woman with a history of congenital hemangioma surgically removed 8 years previously. No radiotherapy had been administered at the time of primary excision. The recurrent tumor consisted of a large lesion occupying nearly all the parotid gland and infiltrating the surrounding soft tissues and overlying skin. Its histopathologic features were typical of epithelioid angiosarcoma. The vast majority of vascular lesions of major salivary glands are benign. However, pathologists should be aware of the remote possibility of malignant transformation in these lesions.
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keywords = gland
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13/39. Epithelioid angiosarcoma of the adrenal gland with cytokeratin expression. Report of a case with accompanying mesenteric fibromatosis.

    A case report of epithelioid adrenal angiosarcoma is presented. Tumor cells showed expression of cytokeratin, factor viii-related antigen, ulex europaeus agglutinin-I, and vimentin. The patient also was found to have mesenteric fibromatosis (abdominal desmoid tumor) and an elevated serum level of estradiol. The authors discuss the unique appearance of these rare tumors, their relationship to hyperestrinism, and review the recent data in the literature showing cytokeratin expression by malignant epithelioid vascular tumors.
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ranking = 23.477483067076
keywords = adrenal gland, adrenal, gland
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14/39. Angiosarcoma of the adrenal gland. Case report.

    The vascular tumours of the adrenal gland are rare, both the benign and the malignant ones. Twenty two cases from the literature are reviewed in a paper by Kareti et al., 1988, among which only one own case of angiosarcoma the authors deem to be the first to be reported. A second case of angiosarcoma of the left adrenal gland, in a 67 y. old man, is herein reported. Notwithstanding a through surgical removal, a quick fatal progression of the disease ensued. Perhaps, considering the high malignancy of these rare tumours, an adjuvant form of treatment seems to be advisable.
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ranking = 34.851840518055
keywords = adrenal gland, adrenal, gland
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15/39. Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non-Alpine region.

    AIM: To report a series of six cases of thyroid haemangiosarcoma (HAS) from a non-Alpine region. methods AND RESULTS: The patients were four females and two males, aged 54-81 years (average 68 years). The tumours presented as large haemorrhagic masses (diameter 40-70 mm, average 56 mm) with extensive necrosis. Histologically, they were composed of polymorphous epithelioid cells with vesicular nuclei and abundant eosinophilic cytoplasm with occasional intracytoplasmic lumina. Mitotic activity was high. Tumor cells expressed vimentin (6/6), CD31 (6/6), FVIII (5/6), CD34 (2/6), and cytokeratins (5/6). One tumour (1/6) over-expressed p53 protein in more than 20% of cells. Ultrastructurally, weibel-palade bodies were present (4/6). Clinical follow-up of four patients (range 3-24 months, median 9 months) showed that two of them have died of the disease 0.5 and 3 months after diagnosis, one died of unrelated causes (with 24 months' uneventful follow-up) and one is alive 21 months after operation with no evidence of disease. CONCLUSIONS: Although thyroid HAS is usually regarded as an extremely aggressive neoplasm with a dismal prognosis similar to anaplastic carcinoma, one of our cases suggests that HAS can behave in a less aggressive way. The morphological, immunohistochemical and ultrastructural findings support the hypothesis that thyroid HAS is a distinct entity, unrelated to other thyroid malignancies.
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ranking = 0.44444444444444
keywords = gland
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16/39. Primary angiosarcoma of the non-irradiated parotid gland: a most uncommon, highly malignant tumor.

    This case report discusses the clinical presentation, imaging, surgery and further treatment and course of a primary angiosarcoma of a non-irradiated parotid gland.
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keywords = gland
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17/39. An intriguing case: malignant mesothelioma presenting as inguinal lymph node metastases.

    A 56-year-old woman presented with a right inguinal mass. biopsy revealed multiple lymph nodes involved with papillary and gland-like structures extending into the surrounding fibroadipose tissue. There was no history of carcinoma or other malignancy. Ultrastructural findings included long microvilli, desmosomes, and tonofilament bundles, indicating metastatic malignant mesothelioma. Malignant mesothelioma only rarely presents as a lymph node metastasis, and electron microscopy is very useful in establishing this diagnosis.
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keywords = gland
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18/39. An unusual angiosarcoma. A case report.

    OBJECTIVE: To document a retroperitoneal angiosarcoma with a 12-year disease-free period. CLINICAL PRESENTATION AND INTERVENTION: A 50-year-old farmer was referred to the urology Clinic, Al-Sabah Hospital, kuwait, with a 1-year history of recurrent left renal colic. Radiological investigations revealed 2 renal cysts at the lower pole and an extrarenal soft tissue mass, presumably of adrenal origin, at the upper pole. laparotomy confirmed both the renal cysts and a circumscribed soft tissue mass. The latter was separate from the adrenal gland but had a vascular connection with an adrenal vessel. Pathological examination showed an encapsulated angiosarcoma. The patient did not have any adjuvant therapy after surgery but was followed up with annual radiological investigations for 12 years. No evidence of recurrence or metastasis was seen. CONCLUSION: The 12-year disease-free period in this case is exceptional for angiosarcomas, which is a high-grade sarcoma.
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ranking = 6.2944855297551
keywords = adrenal gland, adrenal, gland
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19/39. Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers.

    Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma. We report a case of pseudoangiosarcomatous squamous cell carcinoma arising adjacent to decubitus ulcers. The histopathologic examination of a wedge biopsy specimen revealed infiltrative cords of neoplastic cells that formed interanastomosing channels imitating angiosarcoma. Immunohistochemical staining was negative for the endothelial markers (CD31, CD34, and factor viii-related antigen) and positive using cytokeratin antibodies (AE1/AE3 and 34 betaE12). Because of metastatic disease, palliative measures were undertaken and the patient died four months later. To our knowledge, our patient is the first with pseudoangiosarcomatous squamous cell carcinoma of skin developing within decubitus ulcer.
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keywords = gland
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20/39. Primary angiosarcoma of adrenal gland presenting as paraneoplastic syndrome: case report.

    Angiosarcoma is an uncommon neoplasm that rarely involves the adrenal gland. We report on a patient with primary angiosarcoma of the adrenal gland who presented with symptoms best characterized as a paraneoplastic syndrome.
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ranking = 34.851840518055
keywords = adrenal gland, adrenal, gland
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