Cases reported "Infertility, Male"

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11/29. Short arm dicentric y chromosome with associated statural defects in a sterile man.

    A short arm dicentric y chromosome is described as the predominant cell line in a sterile man. The patient also presents with short stature. tooth development appears normal. Only sertoli cells are present in the seminiferous tubules. It is suggested that the function of the gene controlling spermatogenesis in Yq11 in man might be to prevent proliferation or migration of germ cells to the gonad of the early embryo.
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keywords = seminiferous tubule, tubule
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12/29. Deleted Yq in the sterile son of a man with a satellited y chromosome (Yqs).

    Disturbed spermatogenesis and azoospermia are reported in a man with a deleted Y chromosome. The anomalous y chromosome appears in the karyotype as a small metacentric marker. In situ hybridisation using three different Y specific dna probes shows that deletion at Yq11 has resulted in loss of all distal heterochromatin. The sterility of the patient indicates loss also of the azoospermia factor (AZF) located at the Yq distal euchromatic/heterochromatic interface. Microspread and air dried meiotic preparations show a severe impairment of spermatogenesis but rare cells are seen to be progressing to the late prophase stage. The testicular histology shows most of the seminiferous tubules to be completely hyalinised. The father and a fertile brother of the proband show a satellited y chromosome (Yqs) in their karyotypes. The case appears to be the first of its kind reported in which a father with a satellited y chromosome has produced a son carrying a different y chromosome anomaly. The possible derivation of the one from the other is discussed.
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keywords = seminiferous tubule, tubule
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13/29. Yq deletion and failure of spermatogenesis.

    The spermatogenesis of a sterile male carrying a Y long arm deletion was analyzed by meiotic techniques and by light and electron microscopy on testicular biopsies. R-, Q- and C- banding techniques have shown that the Y long arm deletion included the entire heterochromatin and a part of the euchromatic region, with breakpoint between q11.21 and q11.23. The seminiferous tubules showed a sharp decrease in spermatogonia, degenerative phenomena in their nuclei and a spermatogenic block. Abnormal meiotic aspects were observed: pairing failure with atypical diakinesis configurations. These findings confirm the presence of spermatogenesis controlling factors on the distal euchromatic region of the Y long arm.
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keywords = seminiferous tubule, tubule
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14/29. Tubules in semen of infertile patients. Case report.

    Numerous groups of small tubules were observed in the semen of two infertile patients. These structures were about 80 nm in diameter and could be observed within larger concentric tubules. They did not resemble typical microtubules, and did not appear similar to unit membrane.
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keywords = tubule
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15/29. Bilateral carcinoma in situ of testis in infertile man.

    Abnormal seminiferous epithelium with atypical germ cells was studied in 2 previous cases. Embryonal carcinoma occurred within four and one-half years of testicular biopsy. Herein is reported another case of bilateral carcinoma in situ of the testis, presenting abnormal germinal morphology and infertility. The abnormal cells differed considerably from normal spermatogonia, presenting an increased diameter and dense chromatin masses. Apparently normal tubules were also present with normal spermatogenesis. serum gonadotropins and chromosome study were normal. After bilateral biopsy patient was submitted to a right orchiectomy and left varicocelectomy.
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ranking = 0.0081515547782666
keywords = tubule
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16/29. Recovery of fertility in a hypogonadotropic man apparently resistant to gonadotrophin treatment.

    Two subjects affected by panhypopituitarism, 17 and 19 years of age, were evaluated. One of the patients was able to ejaculate sperm (14 X 10(6)/ml) after 12 months of hMG-hCG therapy (75 IU 2 degrees IRP HMG 850 IU hCG twice a week). In the other subject sperm production was not achieved until 6 1/2 years of uninterrupted therapy had been completed although the hCG doses were doubled and then quadrupled. In the patient who responded promptly to the therapy, blood levels of both FSH (2.5) and LH (1.7 (mUI/ml 2 degrees IRP hMG-RIA methods) were indeed detectable through very low. In the patient resistant to the therapy, FSH levels were still detectable (2.2 mUI/ml), but LH was undetectable at all. The seminiferous tubules of this patient contained few spermatogonia, and these would be attributed to the action of FSH by itself. However, the importance of endogenous LH in determining the maturation of the testes is stressed by the very long period of hCG therapy required to obtain in this patient ejaculations of sperm. Careful evaluation must be made of circulating FSH and LH levels, of FSH and LH pituitary stores, and of testicular biopsy scores when assessing prognosis of fertility and adequate treatment of hypogonadotropic subjects. In cases of severe LH deficiency a delayed response of the testis would be expected and recovery of fertility considered possible even when gonadotropin therapy is unsuccessful for many years.
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keywords = seminiferous tubule, tubule
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17/29. infertility in an XX male.

    A case of an infertile male subject with 46XX female karyotype is reported. A testicular biopsy revealed hyalinized tubules with sertoli cells and marked interstitial cell hyperplasia. Chromosomal studies showed the presence of 46 chromosomes with an XX sex chromosome constitution, confirmed with trypsin banding. XX male subjects present an interesting diagnostic problem and need to be differentiated from XXY male subjects with Klinefelter's syndrome. The clinical features of this rare syndrome are discussed and the literature is reviewed.
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ranking = 0.0081515547782666
keywords = tubule
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18/29. Ectopic leydig cells in a seminiferous tubules of an infertile human male with a chromosomal aberration.

    A case of a human male infertility with chromosomal aberration is reported. The patient showed neither mental retardation nor physical abnormalities except that the testes were somewhat small and soft. plasma follicle stimulating hormone and luteinizing hormone were 49.0 and 19.0 mIU/ml. plasma testosterone was 2.6 ng/ml. karyotype was considered to be 46 XY q-, long arms of the y chromosome being deleted. Histological features of the testis were peculiar. seminiferous tubules were small and devoid of spermatogenic cells, consisting only of sertoli cells. Peritubular boundary layer of the tubules showed a marked increase in width due to the increase of collagen fibers. The base of some sertoli cells was seen to protrude into the thickened peritubular boundary layer or, though rare, into the interstitial space. Unusual cells which had a round vesicular nucleus and abundant, dense cytoplasms also occurred in the boundary layer of most tubules. These cells were identified as leydig cells because of an extensively developed smooth endoplasmic reticulum in their cytoplasm, although they lacked Reinke's crystals. These ectopic leydig cells sometimes lay in direct contact with sertoli cells in the seminiferous tubule.
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ranking = 5.0244546643348
keywords = seminiferous tubule, tubule
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19/29. Supernumerary microtubules and prolongation of the middle piece in two infertile patients.

    A new type of sperm abnormality was described in two patients. There was at the same time a high percentage of immotile spermatozoa, supernumerary microtubules organized in more or less complete axonemes, and prolongation of the middle piece, whose mitochondria retain their normal enzymatic activity.
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ranking = 0.040757773891333
keywords = tubule
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20/29. A unique case of Sertoli cell only syndrome with normal gonadotropins.

    A 23-year-old male presented with primary infertility, normal male phenotype, and azoospermia. He had normal basal T, FSH, and LH levels and responded normally to clomiphene citrate stimulation. He also had normal androgen receptors in cultured pubic skin fibroblasts. A testis biopsy showed only sertoli cells and no evidence of seminiferous tubule damage, lacking the fibrosis or Leydig cell hyperplasia usually seen in SCOS. This case of SCOS, combined with those previously reported, suggests that the etiology of SCOS is heterogeneous, with a single common end point, or that it is a single process that has been studied at different developmental stages by different investigators.
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keywords = seminiferous tubule, tubule
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