Cases reported "Keloid"

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1/34. Eruptive paraneoplastic keloids.

    We present a 66-year-old woman who developed eruptive keloids in association with endometrial carcinoma in the absence of trauma, surgery, inflammation, or other known preludes to keloid formation. keloid formation and endometrial carcinoma are both associated with similar cytokine abnormalities and as such, we hypothesize that this is a previously unreported paraneoplastic phenomenon.
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ranking = 1
keywords = formation
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2/34. Scarring in papillary carcinoma of the thyroid: report of two new cases with exuberant nodular fasciitis-like stroma.

    AIMS: To describe two new cases of papillary carcinoma of the thyroid with exuberant nodular fasciitis-like stroma, one of which was characterized by previously unreported transformation into a poorly differentiated lesion. Moreover, we explore the presence of TGF-beta to help to clarify the pathogenesis of the collagen formation. methods AND RESULTS: The case characterized by an aggressive behaviour exhibited areas of transformation into a poorly differentiated (insular) carcinoma of the thyroid. In both cases, as revealed by immunohistochemistry, neoplastic cells produced and secreted high amounts of TGF-beta. On the contrary, TGF-beta immunoreaction was never present in the normal thyroid or in papillary carcinomas without collagen bundles, while a weak, exclusively intracellular reaction was present in a patchy manner in cases showing intratumoral fibrous bundles. CONCLUSIONS: The rare variant of papillary thyroid carcinoma characterized by exuberant stroma may give rise to more aggressive lesions, as do other histotypes of differentiated thyroid carcinomas. TGF-beta, the fundamental cytokine which mediates scarring and activation of myofibroblasts, most probably induces the exuberant stroma.
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ranking = 1.5
keywords = formation
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3/34. Palmar fasciectomy and keloid formation.

    A 53-year-old Caucasian with keloid formation on the palmar surface of the hand following Dupuytren's contracture release is presented. Only two other cases of keloid formation on the hand have been found in English literature, both on black patients. This is the first known case with association of Dupuytren's disease to be reported. Surgical excision of the keloid with intraoperative injection of triamcinolone of the wound edges resulted in clinical cure.
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ranking = 3
keywords = formation
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4/34. noonan syndrome: a case with recurrent keloid formation.

    We describe a 6-year-old boy who presented with erythema and horny, follicular papules on the lateral aspects of the eyebrows and extensor surfaces of the arms. The condition was diagnosed as ulerythema ophryogenes and keratosis pilaris atrophicans faciei. The patient had the characteristic features of noonan syndrome, including dysmorphic facial appearance, congenital heart disease, pectus excavatum, and cubitus valgus, accompanied by a tendency for keloid formation.
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ranking = 2.5
keywords = formation
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5/34. Giant cell fibroblastoma in a child misdiagnosed as a dermatofibroma.

    We report a 9-year-old African-American boy with a giant cell fibroblastoma of the shoulder that was incorrectly diagnosed as a keloid and dermatofibroma. Initial misdiagnosis led to a delay of 4 years in the correct diagnosis, with the tumor producing significant local destruction. We review herein the clinical manifestations, histologic findings, histogenesis, relationship to dermatofibrosarcoma protuberans (DFSP), treatment, and differential diagnosis of giant cell fibroblastoma (GCF). This information is important in correctly diagnosing this uncommon, benign, but locally aggressive and recurrent tumor of childhood. The clinician should consider GCF and DFSP when the pathologic diagnosis of dermatofibroma is made in lesions more than 2 cm in diameter, or when this diagnosis is made in a prepubertal child.
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ranking = 0.5
keywords = formation
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6/34. Fibrodysplasia ossificans progressiva and corneal keloid.

    PURPOSE: To report on the formation of a corneal keloid in a patient with fibrodysplasia ossificans progressiva after excision of a pterygium-like lesion. methods: Clinical and pathophysiological observations and hypothesis concerning pathophysiological mechanisms. RESULTS: An 11-year-old boy with fibrodysplasia ossificans progressiva presented with progressive development of a growing white scar in the central part of the left cornea after excision of a pterygium-like lesion. DISCUSSION: To the best of our knowledge, this is the first case report of a corneal keloid formation in a patient with fibrodysplasia ossificans progressiva. Pathophysiological mechanisms are considered. Therapeutic options are discussed.
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ranking = 1
keywords = formation
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7/34. keloid formation in a simple syndactyly release: a case report.

    keloid formation on the palms of the hands and soles of the feet is rare. A keloid developed 2 months after release of simple syndactyly in a young black child. The process of keloid formation is not completely understood, and surgical correction is not effective.
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ranking = 3
keywords = formation
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8/34. Keloids of the external ear.

    keloid formation is a rare complication of normal scar tissue development, also to the surgeon who performs surgery on the external ear. We are presenting 4 cases of keloid formation which occurred after ear piercing in 2 cases and after otoplasty in another 2 cases. The treatment of keloid formation caused difficulties and is not unequivocal. Therefore we wish to present our experiences as we have seen no cases of keloid formation after otoplasty described in the literature.
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ranking = 2
keywords = formation
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9/34. Distinct phenotype associated with a cryptic subtelomeric deletion of 19p13.3-pter.

    Telomeres are gene rich regions with a high recombination rate. Cryptic subtelomeric rearrangements are estimated to account for 5% of mental retardation/malformation syndromes. Here we present the first patient with a deletion of 19p13.3, identified by subtelomeric FISH analysis. His features included a distinctive facial appearance, cleft palate, hearing impairment, congenital heart malformation, keloid scarring, immune dysregulation, and mild learning difficulties. Subtelomeric FISH analysis identified a deletion of 19p13.3-pter. The deletion size was determined to be 1.2 Mb by FISH analysis. It extended from within the chromosomal region covered by BAC RP11-50C6 to 19pter. The deleted area encompassed approximately 60 genes. Fifteen possible candidate genes were considered with respect to the phenotype, including follistatin-related precursor 3 (FSTL3) and serine-threonine kinase 11 (STK-11).
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ranking = 1
keywords = formation
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10/34. keloid formation on an inconspicuous penis.

    Inconspicuous penis is an umbrella term used to categorize several anatomic anomalies that occur in newborn boys. The consequences of this anomaly may be catastrophic unless it is accurately diagnosed. Repeated circumcisions will accentuate the problem without any solution. keloid formation on the penis is exceptionally rare even though circumcision is a world-wide procedure. Herein, we present a 13-year-old boy with a buried glans penis, micturation difficulty, and keloid formation. He was previously circumcised twice before admission to our clinic. A surgical correction together with intralesional steroid injection was performed. The outcome of this procedure was satisfactory. We conclude that repeated circumcision may not be the best choice of treatment for keloid formation on the penis.
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ranking = 3.5
keywords = formation
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