1/6. Photodynamic therapy of corneal neovascularization with verteporfin.PURPOSE: To describe the effect of photodynamic therapy (PDT) using verteporfin (Visudyne) on corneal neovascularization (CNV) in two patients. methods: Two patients with corneal neovascularization were treated with a nonthermal laser light at 689 nm delivered 15 min after an intravenous infusion of verteporfin. Postoperative outcome of neovascularization was followed clinically (inflammation, intraocular pressure, and visual acuity) and photographically [color photographs and corneal fluorescein and indocyanine green (ICG) angiography] for a minimum of 6 months. RESULTS: Successful photothrombosis of corneal neovascularization was obtained immediately after treatment in the two patients, and regression was verified by corneal fluorescein and ICG angiography. In one case, partial vessel recanalization was observed after 1 month, and treatment was repeated, with complete regression of new vessels. No relevant side effects were observed in our cases. CONCLUSIONS: PDT with verteporfin is an effective and safe procedure indicated for patients with corneal neovascularization; however, multiple sessions may be required.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
2/6. Q-switched Nd:YAG laser treatment for corneal neovascularization.Q-switched Nd:YAG laser treatment to occlude newly formed corneal vessels was performed in patients with herpetic keratitis to reduce corneal opacity and the risk of graft rejection. Nine neovascularized corneas of 9 patients were treated. In 8 of the 9 patients, corneal neovascularization was markedly reduced with a resulting decrease in corneal opacity. Penetrating keratoplasty was performed in 3 patients after the treatment. Two patients in whom YAG laser treatment was effective had uneventful postoperative courses for 13 and 17 months, respectively. In one patient with ineffective YAG laser treatment, rejection occurred 3 months after keratoplasty, and systemic steroid and ciclosporin therapy was needed. Ultrastructural examination of the corneal button removed during keratoplasty from a patient with successful laser treatment showed destruction of vascular endothelial cells and occlusion of the vascular lumen.- - - - - - - - - - ranking = 0.55555555555556keywords = neovascularization (Clic here for more details about this article) |
3/6. Lipofuscinosis of the cornea. A clinicopathologic study of three cases.BACKGROUND: lipofuscin pigments are the indigestible residue of lysosomal activity usually associated with normal aging. Abnormal amounts of lipofuscin also are associated with certain disease processes. The rarity of lipofuscin in the cornea and the similarities between its staining properties and those of intracellular micro-organisms caused great diagnostic problems in three cases. The correct diagnosis of corneal lipofuscinosis was made after extensive histochemical, autofluorescent, and ultrastructural studies. methods: Clinical histories of three patients are correlated with morphologic and histochemical findings on five corneal buttons with lipofuscinosis. RESULTS: The histopathologic features of one cornea with chronic keratitis and three corneas from two patients with bilateral opacities of undetermined origin were mostly similar. Large amounts of lipofuscin pigment were found within macrophages and stromal keratocytes. Other pathologic findings were nonspecific, including phagocytosis of degenerated collagen fibrils, scarring, and neovascularization of the stroma. CONCLUSION: The lipofuscin deposits are probably the consequence of a corneal degenerative process and not its cause, although their pathogenesis remains unclear. Familiarity with the morphologic appearance of corneal lipofuscinosis and its staining and autofluorescent properties is important because the small, 1- to 3-microns deposits may be mistaken for intracellular micro-organisms.- - - - - - - - - - ranking = 0.11111111111111keywords = neovascularization (Clic here for more details about this article) |
4/6. Fungal keratitis due to scopulariopsis brevicaulis in an eye previously suffering from herpetic keratitis.In the case reported, herpes virus I after having caused relapsing keratitis in an eye promoted the formation of a severe corneal ulcer caused by scopulariopsis brevicaulis, a saprophytic mycete found in soil, which only once has been described as the cause of keratitis in man. scopulariopsis was identified microscopically after culturing the conjunctival secretion on Sabouraud dextrose agar medium, while dna probe tests confirmed the absence of herpes virus I. Topical and oral administration of miconazole and scraping of the corneal infiltrate dispersed the infection. Subsequently local steroids were given to reduce the neovascularization, and a therapeutic contact lens was applied because of intercurrent corneal thinning. Three months after beginning antifungal therapy, the visual acuity had increased from 1/120 to 1/10. The case described confirms that S. brevicaulis can cause opportunist infections in a cornea previously damaged by a different agent.- - - - - - - - - - ranking = 0.11111111111111keywords = neovascularization (Clic here for more details about this article) |
5/6. hemorrhage complicating YAG laser feeder vessel coagulation of cornea vascularization.A neodymium:yttrium-aluminum-garnet (Nd:YAG) laser was used in the thermal mode to coagulate blood vessels in a patient with a vascularized corneal leukoma in an attempt to reduce neovascularization before penetrating keratoplasty. Occlusion of the feeder artery at the periphery was followed by a large stromal hemorrhage. A successful keratoplasty was performed 2 days later.- - - - - - - - - - ranking = 0.11111111111111keywords = neovascularization (Clic here for more details about this article) |
6/6. Treatment of corneal neovascularization with argon laser.corneal neovascularization, which is associated with complications in corneal diseases, can cause lipid deposit, decreasing vision, and graft rejection after penetrating keratoplasty (PKP). Corneal laser photocoagulation using an argon laser or yellow dye laser for ablation of corneal neovascularization has been described. We performed corneal argon laser photocoagulation (CALP) in two male patients with corneal neovascularization after herpetic keratitis. One PKP was performed after CALP and restored good vision with no rejection of the graft during an 8 month follow-up period. In the other case we observed visual improvement and no recurrence of corneal neovascularization after CALP.- - - - - - - - - - ranking = 0.88888888888889keywords = neovascularization (Clic here for more details about this article) |