Cases reported "Leishmaniasis, Visceral"

Filter by keywords:



Filtering documents. Please wait...

1/4. Visceral leishmaniasis in costa rica: first case report.

    We describe a 15-month-old eutrophic immunocompetent male who presented with fever, hepatosplenomegaly, pancytopenia, and hypergammaglobulinemia. Leishmania amastigotes were identified in spleen and bone marrow specimens. In addition, tissue culture, animal inoculation, and isoenzyme analysis identified the parasite as leishmania donovani infantum or leishmania donovani chagasi. The infant was successfully treated with an antimonial drug. These findings represent the first case of visceral leishmaniasis reported in costa rica.
- - - - - - - - - -
ranking = 1
keywords = animal
(Clic here for more details about this article)

2/4. Liposomal amphotericin b in drug-resistant visceral leishmaniasis.

    The treatment of visceral leishmaniasis (VL) may be complicated by drug toxicity or intolerance, and by drug resistance. amphotericin b (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common. liposomes have been proposed as an effective way to target drugs at macrophages, which are the cells infected in visceral leishmaniasis. In animals AmB incorporated into liposomes is highly effective against experimental leishmaniasis, with low toxicity. This report is of the successful treatment of a patient with multiply drug-resistant visceral leishmaniasis with a commercially prepared formulation of liposomal amphotericin B (L-AmB) ('AmBisome', Vestar, San Dimas, california, USA). We also report, for comparison, a patient treated with conventional AmB, and preliminary studies in mice comparing the two agents.
- - - - - - - - - -
ranking = 1
keywords = animal
(Clic here for more details about this article)

3/4. Confirmation of clinical differentiation of three Leishmania strains by computerized image analyser system.

    Three human strains of Leishmania, one visceral and two cutaneous leishmaniasis were prepared from both culture and tissue of infected animals and subjected to analysis by computerised image analyser system. The results showed differences in the morphology and nucleic acid contents of the three strains.
- - - - - - - - - -
ranking = 1
keywords = animal
(Clic here for more details about this article)

4/4. Parasite genotypically related to a monoxenous trypanosomatid of dog's flea causing opportunistic infection in an hiv positive patient.

    An hiv positive patient presenting a clinical picture of visceral leishmaniasis co-infection was submitted to a bone marrow aspiration after admission to hospital. Amastigotes forms were seen in the bone marrow aspirate and the parasite grew in culture as promastigotes. Molecular analyses showed that the flagellates isolated did not belong to the genera Leishmania, trypanosoma or Sauroleishmania. It was not possible to establish infection in laboratory animals. in vitro culture of mouse peritoneal macrophages revealed the invasion of the host cells by the flagellates and their killing 48 hr after infection. Opportunistic infection with an insect trypanosomatid was suspected. Further hybridization analyses against a panel of different monoxenous and heteroxenous trypanosomatids showed kDNA cross-homology with Leptomonas pulexsimulantis a trypanosomatid found in the dog's flea.
- - - - - - - - - -
ranking = 1
keywords = animal
(Clic here for more details about this article)


Leave a message about 'Leishmaniasis, Visceral'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.