Cases reported "Leprosy"

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1/13. Increase in the incidence of dapsone hypersensitivity syndrome--an appraisal.

    There has been an increase in the reports of dapsone hypersensitivity syndrome (DHS) in the past few years, coinciding with the introduction of multidrug therapy (MDT) for leprosy world-wide. The exact cause of this phenomenon is not clear. We report four cases of DHS observed among 252 leprosy patients on MDT and one case of DHS in a patient taking dapsone for nodulocystic acne in the dermatology Department of the Osmania General Hospital, Hyderabad, india, between June 1997 and January 1999 with few unusual features. In two of these five patients maculopapular rash was severe and progressed to erythroderma. Introduction of MDT in 1982 has not only decreased the prevalence of leprosy but also brought about a positive change in the attitude of people which increased the voluntary reporting of leprosy patients. This, coupled with improvements in organization of leprosy control and awareness among medical personnel of DHS, are probably the most important reasons for the increased reporting of DHS in recent years.
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2/13. death caused by strongyloides hyperinfection in a leprosy patient on treatment for a type II leprosy reaction.

    strongyloides stercoralis is present worldwide and can cause hyperinfection in patients on long-term immunosuppressive doses of steroids, as is sometimes the case for patients treated for leprosy reactions. Strongyloides hyperinfection can present with ileus, as is discussed in this case report. physicians, including surgeons, should be aware of this entity in order to avoid an unnecessary laparotomy. Though patients may survive if diagnosed at an early stage, strongyloides hyperinfection syndrome has a mortality rate of 87% and prevention is therefore of utmost importance.
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3/13. leprosy: uncommon presentations.

    The uniqueness of the clinical-dermatologic elements of leprosy recommends that control programs worldwide should diagnose the disease based on the so-called main clinical signs: cutaneous-neurological lesions with sensitivity-motor alterations without obligatory bacteriologic or histopathologic examination. The recognition of initial signs and symptoms of Hansen disease sometimes presents difficulties for its diagnosis, especially considering the relevance of an early diagnosis and the present guidelines for performance of decentralized treatment of the patient in the basic health-care network. The clinical cases illustrating this article were selected because of the degree of difficulty found in the confirmation of their diagnoses that required a histopathologic and/or bacteriologic examination.
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4/13. Post-kala-azar dermal leishmaniasis simulating leprosy. (A case report).

    The case of a 40 years male suffering from post-kala-azar dermal leishmaniasis simulating nodular lepromatous leprosy is reported. In countries where leprosy is endemic, other diseases are not infrequently taken to be leprosy (Schaller, 1971). Dermal leishmaniasis is a common cause of confusion in countries where the condition is endemic (Browne, 1964). Dharmendra and Chatterji (1940) discussed in detail the question of differential diagnosis between leprosy and Dermal leishmaniasis. The present communication is concerned with a patient suffering from post-kala-azar dermal leishmaniasis whose skin lesions simulated nodular lepromatous leprosy.
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ranking = 11631.680164256
keywords = leishmaniasis
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5/13. Chance, the prepared mind and children with Hansen's disease.

    1. Hansen's Disease is a chronic disease found in every continent in the world and among all ethnic groups. 2. hawaii is neither a "hotbed" of the disease nor a place where the disease is absent. 3. Hansen's Disease is endemic in these islands, but we also have problems and resources for coping with it. 4. Current treatment approaches to clinical and public health aspects of the disease now offer hope. 5. There is a continuing need to educate patients, families, communities and professional workers in the many aspects of this disease. 6. Opportunity exists for hawaii to become the training nucleus for medical and public health approaches to Hansen's Disease among the populations of the Pacific Basin.
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6/13. Hansen's disease (leprosy): the north carolina experience.

    Hansen's disease presents a large public health problem throughout much of the world but it occurs infrequently in the united states. Only 8,501 cases have been reported since 1921 and 81 percent of these have been from just six states. Typical of many states, north carolina has had only twenty-two case reports over this sixty-eight year period. We present two typical cases we have seen in the past year and briefly review some of the epidemiologic, clinical, and treatment aspects of the disease.
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7/13. Cutaneous leishmaniasis and leprosy.

    Eight patients who had concomitant leprosy and leishmaniasis are described. Two patients with lepromatous leprosy had high resistance leishmaniasis, implying that the immune deficiency in lepromatous leprosy is specific to mycobacterium leprae.
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ranking = 9970.0115693624
keywords = leishmaniasis
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8/13. Otolaryngologic manifestations of Hansen's disease.

    A Mexican migrant farm worker whose condition was previously undiagnosed was examined at the University of utah Medical Center. He had an unusual peripheral neuropathy, ulcerative and nodular skin lesions, and multiple head and neck complaints. Results of the history, physical examination, and multiple biopsies led to the diagnosis of lepromatous leprosy. Although an uncommon disease in the united states, leprosy remains a common cause of head and neck pathologic conditions in many parts of the world and must be considered in the appropriate clinical setting.
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9/13. Post-kala-azar dermal leishmaniasis mimicking leprosy: experience with 4 patients, with some unusual features in 1.

    We report on 4 cases of post-kala-azar dermal leishmaniasis (PKDL). history of kala-azar was available in all 4 patients. Slit-skin smears (SSS) for leishmania donovani (LD) bodies were negative in all 4. In 3 patients hypopigmented lesions were present over the face. Papules and nodules over his lips, tongue, scrotum and dactylitis were some unusual features observed in 1 patient. Histopathological examination showed LD bodies in 2 patients; histopathology was nonspecific in the other 2. All the patients were treated with sodium stibogluconate, 20 mg/kg/day. Infiltrated papules and nodules had subsided by 3 months, while hypopigmented macules took longer to improve. In 3 patients there had previously been a misdiagnosis as leprosy sufferers and they had been treated with antileprosy drugs. Clinical and histopathological differences between PKDL and leprosy are discussed.
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ranking = 8308.3429744687
keywords = leishmaniasis
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10/13. Dermal neuroma simulating leprosy.

    A 45-year-old Pakistani woman reported to a clinic in Karachi with a one-year history of hypopigmented lesions on the left side of the face and neck. On first presentation the lesions were rough-surfaced and hypoaesthetic; the clinical findings in this highly endemic area of the world suggested macular tuberculoid leprosy. The patient was treated with dapsone for a period of 5 years, but with no change in the appearance or size of the lesions. Subsequent biopsies revealed an unusual neuromatoid pathology in the dermis, in which axons were absent on light and electron microscopy, with neurilemmoma being considered as a possible diagnosis.
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