Cases reported "Leprosy"

Filter by keywords:



Filtering documents. Please wait...

1/6. A single skin lesion--an unusual presentation of lepromatous leprosy.

    Lepromatous leprosy presenting as a solitary lesion with a high bacterial count is a rare occurrence. Such a case has been followed at the National Hansen's disease Center, Carville, louisiana, U.S.A., since 1977. The lesion was located on the left elbow and had been present for about nine months. The bacterial index in the lesion was 5 and the morphological index was 0%, but slit-skin smears elsewhere were negative. The histopathology of the lesion was that of subpolar lepromatous leprosy, and the lepromin skin test was negative. growth of the organism in the mouse foot pad was characteristic of mycobacterium leprae, and the patient's response to dapsone monotherapy has been excellent. Therefore, this patient with a single skin lesion has lepromatous leprosy histologically, immunologically, and bacteriologically. This case illustrates the importance of slit-skin scrapings and biopsy in new cases with unusual lesions and, secondly, suggests that there are factors yet undetermined which play a significant role in determining host response to M. leprae.
- - - - - - - - - -
ranking = 1
keywords = lepromin
(Clic here for more details about this article)

2/6. leprosy in Vietnamese refugees: a case report.

    A 41-year-old Vietnamese refugee was found to have tuberculoid leprosy. dapsone treatment cleared her skin lesion, but did not remove the paraesthesia in the right ulnar nerve. Immunological investigations revealed a strongly positive lepromin test and a significant change in the ratio of T-y and T-mu lymphocytes in peripheral blood. The incidence of leprosy in Vietnamese refugees in scandinavia is discussed.
- - - - - - - - - -
ranking = 1
keywords = lepromin
(Clic here for more details about this article)

3/6. Reversal reaction in lepromatous patients induced by a vaccine containing killed ICRC bacilli--a report of five cases.

    Clinico-pathological features of five cases of lepromatous leprosy exhibiting "reversal" reaction with upgrading of lesions following vaccination with ICRC vaccine have been described. Two patients also developed ENL. Associated with the "reversal" reaction, the patients exhibited lepromin conversion. No evidence of fresh nerve lesions was observed in any patient. Besides lepromin conversion, occurrence of "reversal" reaction is yet another evidence of immunogenicity of the ICRC vaccine.
- - - - - - - - - -
ranking = 2
keywords = lepromin
(Clic here for more details about this article)

4/6. Precipitation of type-I (upgrading) reaction in leprosy by skin testing with antigen and irritants.

    Twenty patients of various types of leprosy were skin tested with lepromin, PPD and DNCB to assess their immunological status. Two of the twenty (18 BT; 2 BB) patients belonging to BT type developed signs of acute neuritis of sudden onset about 4 weeks after the test with DNCB, lepromin and PPD. The patients were on DDS therapy already for the last 3-4 months. Presumably DNCB, PPD or lepromin testing had precipitated the reaction. A suggestion is made that lepromin a lower concentration could be used initially and if it gives negative reaction, a higher concentration may be used as in case of PPD testing, particularly in TT and BT cases already put on treatment.
- - - - - - - - - -
ranking = 4
keywords = lepromin
(Clic here for more details about this article)

5/6. Reversal reaction in patients with lepromatous leprosy after transplantation of human fetal thymic grafts.

    An attempt has been made to reconstitute impaired cell-mediated immunity in 1 patient with indeterminate, 4 patients with borderline and 2 patients with polar lepromatous leprosy by grafting three thymus glands obtained from human fetuses of 14--19 weeks gestation. Most of these patients had severe ulcerative erythema nodosum leprosum (ENL) and were intolerant to dapsone. After thymus transplantation these patients were followed for 1 1/2 years. During this period, all conventional chemotherapy had been withdrawn. In most cases, there was dramatic improvement of the clinical condition, resolution of skin lesions, subsidence of ENL, clearance of bacteria from skin and reconstitution of several immunologic deficits; but late lepromin reactivity returned in none, which indicated permanent lose of resistance to mycobacterium leprae.
- - - - - - - - - -
ranking = 1
keywords = lepromin
(Clic here for more details about this article)

6/6. Reversal reactions in lepromatous leprosy following transfer factor therapy.

    Five patients with active leprosy, four with polar lepromatous (LL) and one with borderline lepromatous (BL) disease, were each treated with transfer factor (TF) from approximately 7.4 x 10(9) lymphocytes given in 36 divided doses over a 12-week period. The TF was prepared from blood donated by normal, healthy, lepromin skin test-positive individuals. During treatment all four of the LL patients, but not the BL patient, developed clinical reversal reactions. Histopathologically, skin biopsies in these four LL patients showed evidence of transformation of collections of multibacillary macrophages into paucibacillary epithelioid cells and giant cells. To our knowledge, this is the first histopahtologic documentation of reversal reactions occurring in polar LL. To the extent that reversal reactions are evidence of effective cell-mediated immunity of mycobacterium leprae, these results indicate that TF is capable of at least partial correction of the immunologic deficit of lepromatous leprosy.
- - - - - - - - - -
ranking = 1
keywords = lepromin
(Clic here for more details about this article)


Leave a message about 'Leprosy'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.