1/13. Radiological findings in myxoid liposarcoma of the anterior mediastinum.CT and MR findings of a rare myxoid liposarcoma involving the anterior mediastinum are reported. The mass was a low density lesion with calcific septations and some peripheral frond-like enhancement on CT. MRI showed heterogeneous intermediate to high signal intensity on T1 weighted images and high signal intensity on T2 weighted images. The signal of the mass was not suppressed on fat suppressed images.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
2/13. Benign recurring lipoblastoma in an adult versus well differentiated subcutaneous myxoid liposarcoma: clinicopathologic, immunohistochemical and molecular analysis of a unique case.Subcutaneous myxoid liposarcoma (ML) is exceedingly rare, with only two or three cases having been reported. lipoblastoma (LB), a rare fatty tumor that arises in infants and children, is unknown after adolescence. In contrast to ML, LB is often superficial. The two tumors can be difficult to distinguish due to many histologic similarities. We examined a 0.9 cm superficial subcutaneous nodule from the dorsal neck of a 48 year old man that had been growing slowly. Three and one half years later, a 0.4 cm palpable recurrent nodule was excised from the scar. The patient is now free of disease at 7.5 years. Because of these unusual features, we performed clinicopathologic, immunohistochemical and molecular analysis of this unusual tumor to decide if this represented a rare cutaneous ML or an unprecedented example of LB in an adult. The primary featured a thick fibrous pseudocapsule with foci of lymphocytes and infiltrating nests of semi-mature fetal-appearing adipocytic tissue. This surrounded a more immature cellular-but-cytologically-bland myxoid tissue featuring stellate cells and signet lipoblasts. There were fibrous sep at the periphery and the vasculature was rather inconspicuous. The 0.4 cm diameter recurrence was distinctly lobular and had minute satellite nodules. It was composed of uniform fetal-appearing bland myxoid lipoblastic tissue featuring signet ring lipoblasts surrounded by a few spindle cells. In both tumors, lipoblasts expressed S-100 protein. In the primary, 5% of the lesional cells were FXIIIa dendritic stromal histiocytes while in the recurrence, 15% of the lesional cells were FXIIIa dendritic cells. CD34 stained only scattered small capillaries. The Ki67 proliferation index was 1% in the primary and 3% in the recurrence. RT-PCR assay for TLS/FUS-CHOP fusion transcripts was negative despite three repeat tests performed on paraffin sections of the primary tumor in the presence of good m-rna internal controls. We reviewed the clinicopathologic and cytogenetic features of ML and LB. Based on this review and on the growth pattern, anatomic features and molecular data from the present case, we conclude that this tumor may represent the first reported case of adult LB.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
3/13. Myxoid liposarcoma in a 12-year-old girl.A 12-year-old girl developed a myxoid liposarcoma on the inner side of her right thigh. Liposarcomas are extremely rare at this age compared to benign lipoblastomas, which are the most frequent tumors of fatty tissue in childhood. The prognosis of myxoid liposarcoma is good, especially when, as in this patient, the tumor is located in the subcutis where a large and deep excision is possible and often curative.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
4/13. liposarcoma in the epidural space.STUDY DESIGN: A patient with myxoid liposarcoma in the lumbar epidural space is reported. OBJECTIVE: The subject was treated with marginal resection and posterior instrumentation. SUMMARY OF THE BACKGROUND DATA: liposarcoma is a malignant tumor of the soft tissues. It is commonly seen in the thigh. Lumbar extradural space is an unusual localization. Two cases have been reported with this localization in the literature. methods: The authors have treated a female patient with myxoid liposarcoma in lumbar extradural space with marginal resection and posterior instrumentation. RESULTS: The histopathologic examination showed myxoid liposarcoma. Two cases have been reported in the literature. CONCLUSION: Myxoid liposarcoma is a malignant tumor of the soft tissues. The extradural tumor was probably originated from the epidural fat tissue. Although wide resection is advised in the thigh localization, extradural localization of the tumor can be treated with marginal resection if there is no invasion to the surrounding tissue.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
5/13. lipoblastoma and lipoblastomatosis: a report of two cases and review of the literature.lipoblastoma and lipoblastomatosis are rare benign neoplasms of foetal white fat tissue that occur almost exclusively in infants and children. Two cases are reported and a review of the literature is given. An almost one-year-old girl and a full-term male infant were brought to our hospital with a solid mass in the right thigh. Nine months after total excision of the lipoblastoma, the little girl developed tumour recurrence, with unexpected histopathological maturation. In the case of the little boy, lipoblastomatosis with infiltration of the surrounding muscles, together with involvement of the sciatic and posterior femoral cutaneous nerves was found. Histologically, the tumour showed an unusual inflammatory reaction.The diagnosis of this tumour was made by the pathologist, but the histopathological picture bears a striking similarity to myxoid liposarcoma, and may be indistinguishable. Recent studies describe rearrangements of chromosome 8 q11-q13 region as a new discriminative marker that distinguishes lipoblastoma and lipoblastomatosis from myxoid liposarcoma.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
6/13. Radiologically and histologically mixed liposarcoma: a report of two biphasic cases.We report two cases of liposarcomas showing biphasic patterns, radiologically and histologically. The first case was a 52-year-old man with a 17 x 12 cm intramuscular tumor in the right thigh. MR imaging revealed a mass composed of two components: a fat component and another soft tissue component. Histological diagnosis revealed mixed-type liposarcoma consisting of well-differentiated and myxoid liposarcoma. The second case was a 62-year-old man with a 22 x 15 cm intramuscular tumor in the left calf. MR imaging showed a mass composed of fat and non-fat components. The histological diagnosis was well-differentiated and pleomorphic liposarcoma.- - - - - - - - - - ranking = 3keywords = fat (Clic here for more details about this article) |
7/13. Fine-needle aspiration smears from lipomatous hemangiopericytoma need not be confused with myxoid liposarcoma.Lipomatous hemangiopericytoma (LHPC) is a rare benign soft tissue tumor that may mimic soft tissue sarcoma clinically. Despite the fact that LHPC shares most of the histologic features with solitary fibrous tumor, it may be occasionally misdiagnosed as myxoid liposarcoma or some other type of spindle-cell sarcoma. While some studies have addressed the histological features and origin of LHPC, no reports of cytological findings have been published. The author describes the cytological features of LHPC in two patients with correlations to histological and clinical findings. One of aspirates was misdiagnosed as being myxoid liposarcoma, while the other one was correctly diagnosed by a combination of FNAB and core needle biopsy (CNB). Cytological evaluation of LHPC can be problematic due to its rarity and to its similarity with other spindle-cell or fatty tumors. Correct diagnosis requires an awareness of cytologic features of this rare tumor and the use of ancillary studies.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
8/13. Myxoid liposarcoma with adipocytic maturation: detection of TLS/CHOP fusion gene transcript.This report describes a 49-year-old woman with a well-circumscribed nodule of liposarcoma. The patient noticed a soft, slowly growing mass at the right sural region. Both axial computed tomography and magnetic resonance imaging revealed a soft tissue tumor consisting of nonfatty lesion measuring 5 x 3 x 3 cm circumscribed by a 1-cm thickened fatty area. Histologically, the tumor was made of 2 distinct components: the inner component of the tumor was a classic myxoid liposarcoma with numerous lipoblasts; the outer component was a lipoma-like lesion consisting of mature adipocytes without atypical nuclei. Immunohistochemically, MDM2 overexpression was observed and p53 immunophenotype was negative in both components. Molecular analysis revealed that type 1 TLS/ CHOP fusion gene transcript, characteristic of myxoid/round cell liposarcoma, was detected in both areas.- - - - - - - - - - ranking = 2keywords = fat (Clic here for more details about this article) |
9/13. A case of liposarcoma originating in the chest wall.We encountered and reported one such rare case of liposarcoma which originated in the chest wall. A 60-year-old man came to our hospital with the chief complaint of a phyma in the right anterior chest wall. On palpation, a hard and non-mobile phyma measuring 3 x 3 cm was felt in the chest wall. Chest CT showed a phyma measuring 2.2 x 1.5 cm in the right anterior chest. The periphery of the phyma was smooth, and had a well-defined boundary with the surrounding tissues. Ultrasonic examination revealed that the tumor existed between the major and minor pectoral muscles. The inside of the tumor was nearly uniform, and showed low echo. Punctured cytological examination revealed scattered atypical cells with spindle, foamy or vacuolar sporophores on the mucoid matrix. A fat staining examination revealed lipoblasts with oil red-positive granules. Based on these findings, the patient was diagnosed as having myxoid type liposarcoma. Operation consisted of resection of the skin, subcutaneous tissues, mammary gland, part of major and minor pectoral muscles, the fourth and fifth ribs and pleura. The Reconstruction of the chest wall was performed for defects in the ribs and pleura using Marlex Mesh. Histopathological findings revealed that the tumor was myxoid type liposarcoma.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
10/13. Primary myxoid-type mediastinal liposarcoma.In this paper we present a case of primary mediastinal liposarcoma and describe CT findings of this malignant tumor. In light of the literature we also discussed the mediastinal fatty masses.- - - - - - - - - - ranking = 1keywords = fat (Clic here for more details about this article) |
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