1/12. "Hot" carcinoma of the thyroid. case reports and comments on the literature.It seems somewhat difficult to exactly define the real number of case reports concerning the association of hyperfunctioning thyroid node and carcinoma; the overall incidence of this condition seems, however, to be very rare. Different inclusion criteria are probably a fairly relevant cause of variability in the number of cases reported during the years. A basic classification scheme, as the one here reported, may be of help in characterizing the different possible conditions: 1. the coexistence of carcinoma and focally hyperfunctioning tissue in the same gland but at different locations (not uncommon); 2. the presence of such a large tumour mass that it can compete with normal tissue for tracer uptake, despite being hormonogenetically uneffective in itself; 3. the carcinoma located in the hyperfunctioning adenoma; 4. the real hyperfunctioning carcinoma, where coincidence between hyperfunctioning tissue and malignancy is complete (very rare). Two cases are reported here, respectively belonging to the third and fourth of these categories (the most challenging from a diagnostic point of view). The matter is intrinsically poor from a statistical standpoint: it is therefore difficult to draw definitive conclusions on the subject in operative terms. It is however felt that the systematic evaluation of oncological risk in thyroid nodes, occasionally recommended in the literature, may be cumbersome and not necessarily cost-effective.- - - - - - - - - - ranking = 1keywords = comment (Clic here for more details about this article) |
2/12. Pilomatrix carcinoma with lymph node and pulmonary metastasis: report of a case arising on the knee.A 58-year-old woman presented with a pilomatrix carcinoma on the right knee. The tumor developed at the site of a previous lesion that had been present since she was 30 years old. Histologic study showed the presence of basaloid cells with numerous atypical mitoses, shadow cells, and calcification. After several surgical excisions, the tumor mass infiltrated the subcutaneous tissue, muscle, and bone, resulting in inguinal lymph node and pulmonary metastasis. We also review the literature and comment on the histopathologic differences from other cutaneous tumors.- - - - - - - - - - ranking = 0.25keywords = comment (Clic here for more details about this article) |
3/12. Metastasis of cancer to cancer: report of a case.A case of primary, widely disseminated prostatic carcinoma causing bilateral urinary tract obstruction, hydronephrosis, and papillary necrosis and metastasizing in the substance of an unusual histologic variant of renal cell carcinoma and tubular adenoma of the same kidney is presented. Unusual incidental findings include isolated cardiac amyloidosis and myocardial abscesses. A brief review of the literature is presented. The peculiar tendency for renal cell carcinoma to be the host tumor for other primary carcinomas and various theories to account for this phenomenon are commented upon briefly.- - - - - - - - - - ranking = 0.25keywords = comment (Clic here for more details about this article) |
4/12. Littoral cell angiomatosis with poorly differentiated adenocarcinoma of the lung.We report on a 64-year-old male united states Navy Veteran of world war ii, one of two identical twins, diagnosed with littoral cell angiomatosis of the spleen, liver, and lymph nodes, later found to have a massive poorly differentiated adenocarcinoma involving the mediastinum, adjoining lung, and sternum with widespread metastases. Herein we include our findings at autopsy, pertinent immunohistochemical studies, and a review of the literature pertaining to littoral cell angiomatosis with comment on its association with visceral malignancies.- - - - - - - - - - ranking = 0.25keywords = comment (Clic here for more details about this article) |
5/12. Intracranial meningioma containing metastatic foci.A case of a woman with carcinoma of the lung who died as the result of an expanding fluid mass over the right cerebral hemisphere is presented. Adjacent to this fluid mass was a small meningioma containing a metastatic focus. This was one of many metastases from the primary bronchiolar carcinoma. Photomicrographs are presented and comments regarding tumor collison are given.- - - - - - - - - - ranking = 0.25keywords = comment (Clic here for more details about this article) |
6/12. Small cell anaplastic lung cancer presenting as an ovarian metastasis.An unusual case of small cell anaplastic carcinoma of the lung, presenting as a pelvic mass, is presented. Histochemical and electron microscopic findings confirmed the diagnosis. The pathologic features and unique clinical characteristics are discussed with comments on the topic of metastatic ovarian tumors.- - - - - - - - - - ranking = 0.25keywords = comment (Clic here for more details about this article) |
7/12. Peripheral spindle-cell carcinoid tumor of the lung with type II pneumocyte features. An ultrastructural study with comments on possible histogenesis.A peripheral spindle-cell carcinoid tumor of the lung was studied with the electron microscope. Tumor cells contained dense-core, neurosecretory granules, indicative of their carcinoid identity, and lamellar bodies indistinguishable from those of type II pneumocytes. This observation supports the concept that lung tumors with different histologic and growth patterns may have a common histogenetic basis.- - - - - - - - - - ranking = 1keywords = comment (Clic here for more details about this article) |
8/12. Extraneural metastases from primary pineal tumors. review of the literature.Extraneural metastases from primary pineal tumors are extremely rare: only 15 such cases could be found in th literature. Another case is presented of a 10-year-old boy who developed multiple pulmonary and skeletal metastases from a presumed primary pineal germinoma. The incidence and pathogenesis of distant dissemination in the different types of pineal tumors are discussed, with special comment on the controversial role of the direct surgical approach and shunting of cerebrospinal fluid.- - - - - - - - - - ranking = 0.25keywords = comment (Clic here for more details about this article) |
9/12. Heterotopic brain tissue in the submandibular region and lung. Report of two cases and comments about pathogenesis.Two cases of extracranial heterotopia of the brain are reported. Case 1, in an otherwise normal female baby, had a brain heterotopia in the submandibular region. Case 2, in a still-born female baby with anencephaly, had the heterotopia in the lung. The lesion in case 1 is believed to be an encephalocele that has been pinched off through a cleft in the bone or through a foramen of the skull; the pathogenesis is similar to that of the so-called "nasal glioma". Concerning the pathogenesis of case 2, contrary to the generally supported embolism theory, observation of serial sections of the tumor in the lung favors the aspiration theory according to which amniotic brain tissue fragments, which are dislocated into the amnion because of nonclosure of the ventricle or following destruction of the fetal brain, are aspirated by fetal respiratory movements in the 4th to 6th month of intra-uterine life.- - - - - - - - - - ranking = 1keywords = comment (Clic here for more details about this article) |
10/12. lung carcinoma mimicking malignant lymphoma: report of three cases.Three cases of lung carcinomas with unusual histologic appearances that have received little or no comment in the literature are presented. They were initially confused with malignant lymphoma because of a diffuse proliferation of relatively monotonous cells simulating large-cell immunoblastic lymphoma. In each case, the possibility of malignant lymphoma was excluded with confidence after the immunohistochemical study (leucocyte common antigen negative and cytokeratins positive), although with conventional microscopy several foci of cohesive groups of tumor cells were observed. The tumors were ranked at the clinical stage II or III when they were initially discovered, but all patients died of disease within 1 year. The present three tumors show an aggressive behavior and could be classified into a peculiar variant of 'large cell' carcinoma. It is necessary for surgical pathologists to have an idea of these variants of lung carcinoma in order to avoid erroneous diagnosis.- - - - - - - - - - ranking = 0.25keywords = comment (Clic here for more details about this article) |
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