1/34. Decisive diagnosis of infected mandibular osteoradionecrosis with a Tc-99m-labelled anti-granulocyte Fab'-fragment.The accepted golden standard for detection of inflammatory bone disease is conventional three-phase bone scanning. Hyperperfusion, a high blood-pool activity and elevated bone metabolism are typical signs for an acute osteomyelitis. However, in case of subacute, chronic inflammation, neither elevated blood flow nor high blood-pool activity may be seen. This may cause difficulties in differentiating such cases from neoplastic or postoperative changes. This case report verifies the possible advantage of immunoscintigraphy with Tc-99m-labelled anti-granulocyte Fab'-fragments (LeukoScan) in a patient with infected mandibular osteoradionecrosis, who had equivocal clinical symptoms and questionable radiographic results. LeukoScan is shown to be more sensitive in case of subacute bone inflammation compared with three-phase bone scanning. However, acquisition of delayed images after 24 hours including SPECT is inevitable in case of negative scans during the first hours of investigation.- - - - - - - - - - ranking = 1keywords = bone disease (Clic here for more details about this article) |
2/34. Gorham's disease: a case (including dental presentation) of vanishing bone disease.A case of multicentric vanishing bone disease with maxillofacial involvement in a 4-year-old boy is presented. The clinical and histologic features are described along with the subsequent management of the disease, and the literature concerning this unusual and rare condition is reviewed.- - - - - - - - - - ranking = 5keywords = bone disease (Clic here for more details about this article) |
3/34. Pyknodysostosis--a report of two cases with a brief review of the literature.Pyknodysostosis is a rare sclerosing bone disorder that has an autosomal dominant trait. It is characterized by short stature, brachycephaly, short and stubby fingers, open cranial sutures and fontanelle, and diffuse osteosclerosis, where multiple fractures of long bones and osteomyelitis of the jaw are frequent complications. We present a report of two cases of pyknodysostosis with evidence of long bone fractures and chronic suppurative osteomyelitis of the jaws in one of the cases. Some of the specific oral and radiological findings that are consistent with pyknodysostosis are reported, along with a brief review of the literature.- - - - - - - - - - ranking = 3.2173254576781keywords = osteosclerosis (Clic here for more details about this article) |
4/34. Therapeutic possibilities of long-term roxithromycin treatment for chronic diffuse sclerosing osteomyelitis of the mandible.The clinical efficacy of long-term roxithromycin treatment was examined objectively in nine patients with chronic diffuse sclerosing osteomyelitis of the mandible. roxithromycin was administered orally at a dose of 300 mg/day for between 68 days and 66 months. In seven of the nine cases (77.8%), the symptoms disappeared 1-12 months after the start of therapy. radiography showed that osteolytic changes (evident from 'moth-eaten' appearance of bone) had improved but that osteosclerosis had persisted or become more predominant by the end of therapy. Therefore, the optimum duration of treatment should be decided according to the amelioration of symptoms along with the disappearance of osteolytic findings in radiographs. Diarrhoea and stomach discomfort occurred in one case, and liver dysfunction in another, but these adverse reactions were relatively mild. The mechanism of action of roxithromycin in this study is not yet fully understood, but our results indicate that long-term roxithromycin treatment may be useful for diffuse sclerosing osteomyelitis of the mandible and should be attempted before surgical treatment is considered.- - - - - - - - - - ranking = 3.2173254576781keywords = osteosclerosis (Clic here for more details about this article) |
5/34. Free fibular flap reconstruction in mandibular osteopetrosis.Extensive involvement of the mandible with sclerosis secondary to the rare genetic disorder, osteopetrosis, is a difficult reconstructive problem. It is typically refractory to conservative management or local surgical methods because of vascular compromise of the bone. For this reason, total resection of all involved bone with microvascular graft reconstruction is an ideal method for mandibular reconstruction in osteopetrosis that has not been previously reported.- - - - - - - - - - ranking = 69.772242777518keywords = osteopetrosis (Clic here for more details about this article) |
6/34. osteomyelitis complicating osteopetrosis--a case report.osteomyelitis of the jaws is uncommon but can be a complication of extraction or exposure of teeth in patients who are immunosuppressed or have undergone radiotherapy to the head and neck region. We report a case of osteomyelitis in a patient who has osteopetrosis. The initial clinical presentation was that of an infected retained root, secondary to denture trauma to the supporting tissues. Radiological interpretation was difficult owing to the increased bone density and surgical exploration revealed only a dense region of necrotic bone.- - - - - - - - - - ranking = 58.143535647932keywords = osteopetrosis (Clic here for more details about this article) |
7/34. Differential diagnosis and treatment of autosomal dominant osteosclerosis of the mandible.A 20-year-old patient who presented with concerns about her large mandible was found to have a generalized mild cortical sclerosis. She was treated successfully with staged orthognathic surgery, despite the dense sclerosis of the jaws.- - - - - - - - - - ranking = 12.869301830713keywords = osteosclerosis (Clic here for more details about this article) |
8/34. Otolaryngological complications of osteopetrosis.osteopetrosis is a rare inherited bone disease that affects both humans and various mammals. The authors report on two cases of osteopetrosis with otolaryngological complications. One patient had the childhood form and presented with chronic otitis media and brain abscess. The second patient had the adult form and presented with sinusitis from tooth extraction which developed into chronic osteomyelitis of the maxillary bone.- - - - - - - - - - ranking = 59.143535647932keywords = osteopetrosis, bone disease (Clic here for more details about this article) |
9/34. Brown tumor in children with normocalcemic hyperparathyroidism: a report of two cases.Brown tumor is an important sign of a number of metabolic bone diseases. Normocalcemic hyperparathyroidism, a rare childhood pathologic finding, reveals itself with brown tumors as the only initial sign. In this study, two cases of normocalcemic hyperparathyroidism accompanied by mandibular brown tumors are presented.- - - - - - - - - - ranking = 1keywords = bone disease (Clic here for more details about this article) |
10/34. cherubism in siblings: a case report.cherubism is a non-neoplastic bone disease characterized by clinically evident bilateral, painless enlargements of the jaws that are said to give the patient a cherubic appearance. cherubism may appear in solitary cases or in many members of the same family, often in multiple generations. On radiography, the lesions exhibit bilateral multilocular radiolucent areas. Histopathologic evaluation reveals proliferating fibrous connective tissue containing numerous multinucleated giant cells. Since the first description of this condition in 1933, almost 200 cases have been reported. We describe cherubism in 2 siblings and briefly review the literature on this subject.- - - - - - - - - - ranking = 1keywords = bone disease (Clic here for more details about this article) |
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