Cases reported "Melanosis"

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11/34. minocycline-associated intra-oral soft-tissue pigmentation: clinicopathologic correlations and review.

    BACKGROUND: Intra-oral minocycline staining of alveolar bone and teeth is well-described in the literature. minocycline-induced discoloration of oral soft tissues is less common and has been often attributed to staining of the underlying bone. AIM: This report documents the clinical and histopathologic features of a case of actual oral soft tissue minocycline-induced pigmentation. The patient, a 45-year-old Caucasian female, presented with pigmentation of the gingiva, lips, and nail beds of recent onset. The past medical history revealed initiation of minocycline therapy 6 months earlier for dermatological concerns. Histopathologic examination of biopsy specimens from the gingiva and lip showed evidence of increased melanin/melanocytes in the epithelium and melanin/melanophages in the connective tissue. A working diagnosis of drug-associated pigmentation was determined and the patient discontinued immediately minocycline therapy. Nine months after cessation of minocycline the patient exhibited a marked reduction in pigmentation. CONCLUSION: Systemic minocycline treatment has the potential to induce significant and esthetically objectionable discoloration of the gingiva and oral mucosa. A brief review of the literature is presented to help understand this uncommon finding that should be included in the differential diagnosis of spontaneous discoloration of intra-oral soft tissues.
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keywords = bone
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12/34. Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch.

    Familial adenomatous polyposis (FAP) is an autosomal dominant condition with near complete penetrance, characterised by the presence of numerous adenomatous polyps of the colon and rectum. melanosis coli describes the brownish-black discolouration of the colon resulting from the accumulation of a granular pigment in the phagosomes of macrophages in the colonic lamina propria. The presence of melanosis pigment in pericolonic lymph nodes has been reported in patients with coincidental melanosis coli, following segmental colonic resection. We report a unique case of FAP with melanosis pigment in lymph nodes in the small bowel mesentery that initially prevented a restorative proctocolectomy but that resolved following a colectomy, subsequently facilitating formation of an ileo-anal pouch.
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ranking = 12807.681152
keywords = macrophage
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13/34. Pseudomelanosis duodeni: a case report with electron-probe X-ray analysis.

    Pseudomelanosis of the duodenum is rare. Only 17 cases have been documented in the world literature. A 59-year-old man presented to Bankstown Hospital, new south wales with dysphagia. On endoscopy, he was found to have melanosis of the duodenum in addition to oesophageal ulceration. It has been previously suggested that the pigment ferrous sulphide is derived from gastro-intestinal bleeding and lodged in the macrophages. A detailed examination of the pigment, including X-ray probe micro-analysis at various levels of the intestinal epithelium as well as in macrophages is presented.
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ranking = 25615.362304
keywords = macrophage
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14/34. Diffuse melanosis in metastatic malignant melanoma.

    The skin of a patient with diffuse melanosis as a result of malignant melanoma was examined by light microscopy, immunohistochemistry, and electron microscopy. Our findings indicate that the slate-blue discoloration in this patient was due to pigment deposition in dermal macrophages and endothelial cells. Multiple attempts to identify disseminated metastatic melanoma cells were unsuccessful.
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ranking = 12807.681152
keywords = macrophage
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15/34. Biphasic amyloidosis arising from friction melanosis.

    A 40-year-old woman who had used nylon towels in the bath for about 10 years noticed hyperpigmentation on the prominent regions over the bones of the trunk and extremities. She also developed lichenoid papules with itching on her back. Histologically, both the pigmented and the papular lesions had amyloid deposits beneath the epidermis. In this case it is presumed that the papular lesions with amyloid (lichen amyloidosus) developed initially from friction melanosis which became macular pigmented lesion (macular amyloidosis). The etiologic factor of these sequential pathologic changes is considered to be repeated scrubbing with nylon towels.
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ranking = 0.5
keywords = bone
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16/34. Pseudomelanosis of the duodenum. Endoscopic, histologic, and ultrastructural study of a case.

    We present the endoscopic, microscopic, and histochemical studies of a patient with pseudomelanosis of the duodenum. The pigment was located mainly in the lysosomes of macrophages in the lamina propria and was heterogeneous, showing features of melanin, pseudomelanin, and hemosiderin. The origin of this pigment remains unknown, but antihypertensive medication may have played a role.
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ranking = 12807.681152
keywords = macrophage
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17/34. Further characterization of the pigment in pseudomelanosis duodeni in three patients.

    Pseudomelanosis duodeni is a rare condition in which dark pigment accumulates in macrophages located in the lamina propria of the duodenal mucosa. Three cases are reported here and the literature is reviewed. No clinical association can be found that points clearly to the underlying etiology. Electron probe x-ray microanalysis was used to study the pigment in macrophage granules in 2 of our patients and demonstrated high iron and sulfur content. iron accumulation in ferritinlike particles was detected in absorptive cell lysosomes. A possible mechanism for the accumulation of absorbed iron by macrophages is considered.
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ranking = 38423.043456
keywords = macrophage
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18/34. Conjunctival pigmentation following pars plana vitrectomy.

    A 32-year-old white man developed distinctive episcleral and conjunctival pigmentation surrounding a sclerotomy site 6 weeks after vitrectomy and retinal reattachment surgery. The conjunctival lesion was biopsied during a second operation to remove an epiretinal membrane causing macular pucker. light and electron microscopic studies demonstrated melanin granules extracellularly and within macrophages.
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ranking = 12807.681152
keywords = macrophage
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19/34. Diffuse meningeal melanosis (an unusual presentation).

    An unusual presentation of diffuse meningeal melanosis with involvement of the temporal bones, the spheno-ethmoidal complex, the pharynx and the viscera is reported.
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ranking = 0.5
keywords = bone
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20/34. Hermansky-Pudlak syndrome with special reference to lysosomal dysfunction. A case report and review of the literature.

    In addition to the triad in the Hermansky-Pudlak syndrome (tyrosine-positive oculocutaneous albinism, mild bleeding tendency with a normal platelet-count and widespread accumulation of ceroid-like pigment in various organs), we document severe pulmonary fibrosis, pseudomelanosis coli and deeply pigmented renal cortex. In the liver, innumerable number of pigment-laden kupffer cells and macrophages in the Glisson capsule were seen. Interestingly, many intralysosomal accumulations of the pigment within the hepatocytes were found by electron microscopy, suggesting that these configurations possibly resulted from a dysfunction of the lysosome itself, especially with regard to loss of digestive and secretory activity. The triad and other complications may also be resultants of a lysosomal dysfunction.
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ranking = 12807.681152
keywords = macrophage
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