Cases reported "Menopause, Premature"

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1/4. pregnancy in a patient with gonadotropin-resistant ovary syndrome.

    The case of a patient with gonadotropin-resistant ovary syndrome is discussed. ovulation was successfully induced by the administration of human chorionic gonadotropin and by estrogen replacement therapy. A total of three pregnancies occurred. The first two pregnancies resulted in blighted ova. The third pregnancy resulted in a normal term delivery.
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ranking = 1
keywords = ovary syndrome, ovary
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2/4. An association among blepharophimosis, resistant ovary syndrome, and true premature menopause.

    Four cases are described of a very rare association among blepharophimosis, resistant ovary syndrome, and true premature menopause. plasma levels of follicle-stimulating hormone and luteinizing hormone were significantly elevated and estradiol significantly decreased in all four cases. Ovarian biopsies demonstrated large numbers of unstimulated primordial follicles in three cases and no follicles in one case. Two of the four women were sisters, with the older having true premature menopause and the younger having resistant ovary syndrome. The explanation for the association of blepharophimosis with primary ovarian dysfunction is unknown, but the possibility of a microdeletion of genetic material containing two geographically associated but independent genes could not be confirmed or excluded by high-resolution chromosome banding. All families affected by the autosomal dominant condition of blepharophimosis should be counseled about the high incidence of ovarian dysfunction and female infertility, at least in one form of the syndrome.
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ranking = 1.2
keywords = ovary syndrome, ovary
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3/4. radiation-induced premature menopause: a misconception.

    PURPOSE: To disprove the common view that women who have undergone irradiation to fields excluding the pelvis are at risk for radiation-induced premature menopause, we reviewed menstrual function and fertility among women treated with subtotal lymphoid irradiation for Hodgkin's disease. methods AND MATERIALS: Treatment and follow-up records of all women less than age 50 at the time of diagnosis of Stage I or II supradiaphragmatic Hodgkin's disease, treated with subtotal lymphoid irradiation alone and enrolled in radiotherapy trials from 1967 to 1985, were reviewed. In addition, patients were surveyed regarding their menstrual status and fertility history. RESULTS: Thirty-six women, aged 10 to 40 years, with normal menstrual function at the time of Hodgkin's diagnosis, were identified. Mean follow-up was 14 years, with a range of 1.25-22.75 years. The average radiation dose to mantle and paraaortic fields was 40-44 Gy; the calculated scatter radiation dose to the pelvis at the ovaries was 3.2 Gy. There were 38 pregnancies in 18 women; all offspring are normal. One of 36 women (2.7%) experienced premature menopause. The reported rate of premature menopause in women who have not undergone irradiation is 1-3%; not significantly different than the rate in our study. There is a syndrome whereby antibodies to several endocrine organs occur (including the ovary), which is associated with premature ovarian failure. This syndrome may be associated with prior radiation to the thyroid, such as that given by mantle irradiation for Hodgkin's disease. We report such a case. CONCLUSION: There is little risk of premature menopause in women treated with radiation fields that exclude the pelvis. women with presumed radiation-induced premature menopause warrant an evaluation to exclude other causes of ovarian failure, such as autoimmune disorders.
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ranking = 0.00047163892147438
keywords = ovary
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4/4. Familial blepharophimosis with ovarian dysfunction.

    Three cases including two sisters and one brother with blepharophimosis are described. Their father also had blepharophimosis. Moreover, the elder sister initially presented with resistant ovary syndrome and thereafter true premature menopause, while the younger one presented with resistant ovary syndrome. The explanation for the association of blepharophimosis with primary ovarian dysfunction is unknown, but the possibility of a microdeletion of genetic material containing two geographically associated, but independent genes could not be confirmed or excluded. All families affected by blepharophimosis should be counselled about the high incidence of ovarian dysfunction and female infertility, at least in one form of the syndrome.
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ranking = 0.4
keywords = ovary syndrome, ovary
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