Cases reported "Mouth Diseases"

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11/83. Primary ectopic thyroid papillary carcinoma in the floor of the mouth and tongue: a case report.

    We report a rare case of papillary carcinoma in the tongue and floor of the mouth with metastasis in cervical lymph nodes. Treatment was by total thyroidectomy with right radical lymph node dissection of the neck, followed by 60 Gy of radiotherapy and 100 mCi (131)I. Pathological examination of the thyroid gland showed no primary cancer. We review publications about ectopic thyroid and the value of antithyroglobulin immunostaining for diagnosis and treatment of the tumour.
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12/83. Case challenge: persistent oral tenderness.

    An 81-year old male presents with a chief complaint of oral soreness, primarily involving the tongue and denture-bearing mucosa. Symptoms have been present for approximately two months and have not been relieved by denture adjustments.
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13/83. Oral lichenoid reaction to imatinib (STI 571, Gleevec).

    Imatinib or STI 571 is a phenylaminopyrimidine derivative and a member of a new class of drugs known as signal transduction inhibitors. These compounds specifically inhibit the proliferation of v-abl- and bcr-abl-expressing cells and have recently been approved as treatment for chronic myeloid leukaemia (CML). Results have been promising, and imatinib may well be the best single agent for the treatment of CML in the near future. Here we report an erosive oral lichenoid eruption confined to the buccal mucosa and dorsum of the tongue which appeared 12 weeks after commencement of imatinib in a 72-year-old woman with CML. The histology was consistent with a lichenoid drug eruption. The lesions resolved upon withdrawal of the drug. To our knowledge, this is the first reported lichenoid reaction to imatinib, and in the setting of CML it must be differentiated from idiopathic lichen planus, paraneoplastic pemphigus and graft-versus-host disease.
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14/83. Dyschromatosis universalis hereditaria.

    Dyschromatosis universalis hereditaria is a clinically heterogenous disorder. We report two unrelated Indian patients with dyschromatosis universalis hereditaria, who had generalized and progressive reticulate hyper- and hypo-pigmentation of the skin. The oral mucosa and tongue also showed mottled pigmentation. Intriguingly, the palms and soles were also affected with a diffuse hyper-pigmentation interspersed with spotty de-pigmented macules. Dystrophic nail changes with pterygium formation were seen in one case. Histopathology revealed a variable degree of pigmentary incontinence. Although the precise aetiology of this disorder is not yet known, the clinicopathological findings implicate an inherent abnormality of melanosomes or melanin processing.
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15/83. Osseous choristoma of the oral soft tissue. Case report.

    Oral osseous choristoma is a rare developmental alteration, their principal localization is nearly to base of the tongue (foramen caecum). The oral mucosa localization of osseous choristoma is extremely rare. At date only 10 cases of oral mucosa osseous choristoma had been reported. In the present paper we reported a new case of oral mucosa osseous choristoma in a klippel-feil syndrome patient. A review of available literature was made. We presented a 28 years old female patient who showed into the right oral mucosa, a hard, mobile, and asymptomatic mass, with minimum 4 years of evolution. The histological image showed a lesion constituted by lamellar bone, osteocytes and haematopoyetic tissue. The diagnosis of osseous choristoma was made. It is discusses their possible association with klippel-feil syndrome. The osseous choristoma of buccal mucosa is most frequently in fifth decade of the life although is reported between 12-to-64 years old, with a female predisposition.
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16/83. oral manifestations of paracoccidioidomycosis. Report of 21 cases from argentina.

    The present study describes 21 Argentinian patients living in the province of Corrientes, who had developed oral manifestations due to paracoccidioides brasiliensis infection. Of these, 20 patients were men and one a woman. patients were of an average age of 39 years (range 25 to 72 years). Approximately, 76.2% of the patients were farmers. Gingival lesions were observed in 76%. Also, the tongue (71%) and the lips (62%) were frequently affected. Cytological smears and histopathology showed the characteristic fungal cells with the characteristic granulomatous inflammatory reaction consisting of lymphocytes, epithelioid cells and giant cells of the Langhans type. All patients except one had detectable pulmonary involvement. Therapy consists of long-term administration of itraconazole. oral manifestations of paracoccidioidomycosis are characteristic in their clinical presentation. early diagnosis and adequate therapy may prevent extensive tissue destructions. Long-term follow-up is mandatory.
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17/83. Simultaneous occurrence of sublingual dermoid cyst and oral alimentary tract cyst in an infant: a case report and review of the literature.

    The simultaneous occurrence of sublingual dermoid cyst and oral alimentary tract cyst is very rare. A literature search revealed only two previous cases and one other, where a dermoid cyst was associated with a gastrointestinal microcyst in its cyst wall. We report a case of a six-week-old Caucasian boy, who presented with swelling of the tongue and floor of mouth, which interfered with his normal feeding and swallowing. The swelling was rapidly increasing in size and had become an airway threat. magnetic resonance imaging (MRI) scans revealed the presence of a lobulated lesion arising in the region of the floor of the mouth on the left and a further lobule which actually invaded the soft tissues of the inferior aspect of the tongue. These two cystic lesions were excised surgically via an intraoral approach and the infant made a complete recovery postoperatively, with resumption of normal feeding and swallowing. The differential diagnoses and approach to sublingual swellings are discussed and the importance of prompt treatment is emphasized.
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18/83. Local primary (AL) amyloidosis in the palate. A case report.

    Oral amyloidosis is usually presented in the tongue and is often regarded as a paraneoplastic phenomenon. We present a rare case of primary local amyloidosis in the palate of an 80-year-old male. No simultaneous general illnesses or malignancies were detected in spite of extensive assessments by specialists in internal medicine.
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19/83. Oral papillary plasmacytosis resembling candidosis without demonstrable fungus in lesional tissue.

    Two cases with exuberant papillary and nodular hyperplasia of the hard and soft palates are described. Both were elderly edentulous men with bilateral angular stomatitis. The papillary hyperplasia extended as far as the epiglottis and was associated with swelling and fissuring of the upper lip in patient 1. In patient 2, the palatal change extended to the maxillary gingiva and was associated with smooth plaques and fissuring of the dorsal tongue. histology of both cases showed a dense polyclonal plasma-cell infiltrate with overlying epithelial hyperplasia, parakeratinization and neutrophil micro-abscesses suggesting candida infection but fungal elements could not be demonstrated. Patient 1 also showed defective cellular immunity to candida antigen which was reversed by treatment with ketoconazole and levamisole, antedating clinical improvement.
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20/83. Considerations on the diagnosis of oral psoriasis: a case report.

    This paper discusses the difficulties in making a definitive diagnosis of oral psoriasis based upon clinical and histological evidence only. A young black male presented with multiple lesions showing erosions, fissures, and yellowish scales on the vermilion borders of both lips. He also had erythematous-erosive areas on the gingivae, a fissured tongue showing greyish areas on its ventral surface, whitish lesions and longitudinal sulci in the hard palate with lacelike lesions on the soft palate. Biopsies from the lower lip, gingiva and soft palate showed hyperkeratosis, spongiosis, acanthosis, and elongation of rete ridges. In addition, collections intraepithelial micro-abscesses of Munro were observed. These findings are consistent with oral psoriasis. Typical cutaneous lesions and a family history of psoriasis were absent.
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