31/128. myalgia and cramps associated with zolmitriptan.OBJECTIVE: To report a patient with myalgia and cramps possibly induced by the antimigrainous agent zolmitriptan. CASE REPORT: A 27-year-old woman with episodes of common migraine developed cramps and generalized myalgia after the use of intranasal zolmitriptan 5 mg to treat 3 episodes of migraine. This side effect had not occurred with oral zolmitriptan 2.5 mg. CONCLUSION: myalgia and cramps should be considered a possible dose-dependent adverse effect of zolmitriptan.- - - - - - - - - - ranking = 1keywords = cramp (Clic here for more details about this article) |
32/128. muscle cramp as a feature of neuromuscular disease. Five neuromuscular disorders, accompanied by frequent muscle cramps.Five case reports of neuromuscular disorders, presenting with frequent muscle cramps are discussed. Clinical diagnosis and pathophysiologic concepts are highlighted.- - - - - - - - - - ranking = 1.8475244295654keywords = cramp, muscle cramp, muscle (Clic here for more details about this article) |
33/128. early diagnosis and treatment reverse clinical features in Hoffmann's syndrome due to hypothyroid myophaty: a case report.hypothyroidism is a frequently diagnosed endocrine disorder that has characteristic clinical signs and symptoms. Myopathy is one of the manifestations of hypothyroidism and relatively common. We report a case of Hoffmann's syndrome due to hypothyroid myopathy documented by clinical features, laboratory findings and positive response to thyroid hormone replacement therapy. A man, age of 22, was diagnosed as having primary hypothyroidism at the age of five, had been describing progressive weakness in his arms and legs for two months and complained about generalized muscle cramps and pain. He was diagnosed with Hoffmann's syndrome with low levels of thyroid hormones and high levels of muscle enzymes. After six months of thyroid hormone replacement therapy, both the clinical picture and laboratory findings were remarkably improved.- - - - - - - - - - ranking = 0.25523267670092keywords = cramp, muscle cramp, muscle (Clic here for more details about this article) |
34/128. exercise-induced cramp, myoglobinuria, and tubular aggregates in phosphoglycerate mutase deficiency.We report two patients in whom phosphoglycerate mutase (PGAM) deficiency was associated with the triad of exercise-induced cramps, recurrent myoglobinuria, and tubular aggregates in the muscle biopsy. serum creatine kinase (CK) levels were elevated between attacks of myoglobinuria. forearm ischemic exercise tests produced subnormal increases of venous lactate. Muscle biopsies showed subsarcolemmal tubular aggregates in type 2 fibers. Muscle PGAM activities were markedly decreased (3% of the normal mean) and molecular genetic studies showed that both patients were homozygous for a described missense mutation (W78X). A review of 15 cases with tubular aggregates in the muscle biopsies from our laboratory and 15 cases with PGAM deficiency described in the literature showed that this clinicopathological triad is highly suggestive of PGAM deficiency.- - - - - - - - - - ranking = 0.71431272443281keywords = cramp, muscle (Clic here for more details about this article) |
35/128. Psychiatric aspects of writer's cramp.Although its aetiopathogenesis is still unknown, writer's cramp is meanwhile regarded essentially an organically induced disorder. However, as shown by this interdisciplinary study, psychodynamic factors should not be neglected. Special attention should be given to the patients' experience of the syndrome and secondary psychoreactive processes.- - - - - - - - - - ranking = 0.71428571428571keywords = cramp (Clic here for more details about this article) |
36/128. Cramps: a sign of motoneurone 'bistability' in a human patient.In a patient suffering from severe long-lasting cramps, cramps were triggered in the triceps surae by volleys in homonymous Ia afferents (elicited by electrical stimulation or by tendon taps) and were interrupted by antidromic invasion and Renshaw inhibition of triceps surae motoneurones (evoked by a single maximal stimulation of motor axons). This result suggests that the mechanisms which generate the cramps are intrinsic to alpha-motoneurone somata. A similar on-off switching of a self-sustained motor discharge has been observed in the decerebrate cat and recognized to depend on 'bistability' of the motoneuronal membrane. We propose that the same mechanism may be at the origin of the cramp discharge.- - - - - - - - - - ranking = 0.57142857142857keywords = cramp (Clic here for more details about this article) |
37/128. tocainide therapy in muscle cramps and spasms due to neuromuscular disease.Significant improvement in symptoms of disabling cramps and muscle spasms was obtained in 9 patients with motor neuron diseases, tetany, and myotonic disorders who were treated with tocainide, a lidocaine analog. No significant side effects were observed except for light-headedness and fatigue in 1 patient, who also showed slight prolongation of intraventricular conduction time. tocainide is useful in treating disabling muscle spasms and cramps associated with conditions characterized by neuromuscular irritability. This effect is probably based on stabilization of the membrane potential at various levels (motor neurons, peripheral nerve, or muscle fiber membrane).- - - - - - - - - - ranking = 1.3066314874444keywords = cramp, muscle cramp, muscle (Clic here for more details about this article) |
38/128. quinine-induced disseminated intravascular coagulation.Recurrent disseminated intravascular coagulation occurred in 3 women after ingestion of quinine tablets for cramp. All had circulating quinine-dependent antibodies to platelets and in 2 there was initial evidence of antibody consumption, with low titres that rose steeply over the next few days and remained high for many months.- - - - - - - - - - ranking = 0.14285714285714keywords = cramp (Clic here for more details about this article) |
39/128. Muscle cramps in the calf as presenting symptom of sarcoidosis.A patient is described, who presented with pain in the calf due to a palpable nodule as the presenting symptom of sarcoidosis. The patient was treated with rest and diclofenac, followed by intralesional injections with triamcinolone hexacetonide and became free from pain.- - - - - - - - - - ranking = 0.57142857142857keywords = cramp (Clic here for more details about this article) |
40/128. Steroid-responsive tubular aggregate myopathy.We report a man with an acute myalgia/cramp syndrome and tubular aggregates on his muscle biopsy. He was placed on prednisone and was found to be exquisitely sensitive to the drug, with changes of only 5 mg precipitating recurrence of symptoms. He was eventually tapered off all steroids, without symptoms, and repeat biopsy showed no tubular aggregates. We recommend similar patients be given a trial of high-dose steroids.- - - - - - - - - - ranking = 0.14287064793069keywords = cramp, muscle (Clic here for more details about this article) |
| <- Previous || Next -> |