Cases reported "Mycoses"

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1/36. Therapeutic experience with fluconazole in the treatment of fungal infections in diabetic patients.

    diabetes mellitus is associated with a higher incidence of certain infections, including fungal infections like rhinocerebral zygomycosis (RCZ) and cutaneous candidosis. As the pathophysiology of increased susceptibility to infection of diabetic patients is very complex, a general therapeutic approach is not existing yet. Appropriate diabetes control remains as the best preventive measure. Nevertheless, effective drug therapy is very often required. fluconazole has proven efficacy in prophylaxis, treatment and suppressive therapy of both systemic and superficial fungal infections, especially in candidosis and cryptococcosis. Therefore it is used routinely against fungal infections in diabetes (FID). Clinical efficacy of fluconazole against cutaneous candidosis, oropharyngeal candidosis (OPC) and vulvovaginal candidosis (VVC) has been confirmed in more than 100 studies, involving more than 10,000 patients (pts). The overall success rate is 90%, with a mean dosage of 100-200 mg/d. In severe cases, e.g. in OPC in late-stage AIDS pts or in recurrent VVC, higher dosages of up to 800 mg/d may be required. In the treatment of RCZ, therapeutic experience with fluconazole is limited. Four diabetic pts have been treated with dosages of 200-300 mg/d and all of them recovered. Nevertheless, treatment of RCZ should include surgical debridement combined with aggressive antifungal therapy. In conclusion, proven efficacy and the excellent safety profile justify the routine use of fluconazole in the treatment of FID.
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ranking = 1
keywords = zygomycosis
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2/36. Deep mycoses prevalent in the Igbos of nigeria.

    During a 3-year period, 6 cases of Africal histoplasmosis, 6 of phycomycosis and 5 of mycetoma were recognized histologically in 0.4 per cent of 4,307 surgical specimens removed from Nigerian Igbos and examined at a central laboratory. Undoubtedly, these cases are but the representatives of the mycological iceberg existing in this part of the world. Our experience suggests that collaboration between physicians, pathologists and mycologists should bring about increased international awareness of the deep mycoses.
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ranking = 74.767210646592
keywords = phycomycosis
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3/36. Rhinofacial zygomycosis caused by conidiobolus coronatus. A case report.

    A case of rhinofacial zygomycosis with of years duration, caused by conidiobolus coronatus is described. The patient, a 72-years-old woman, presented with a bilateral distortion of the subcutaneous tissue and disfigurement of the face. Treatment with ketoconazole and potassium iodide did not prevent several relapses. At present she is still under treatment with fluconazole with clinical healing. Histopathological and mycological examination confirmed the dermatological diagnosis. An increasing number of cases of zygomycosis caused by fungi of the order entomophthorales have also been reported in the Northern and Northeastern States of brazil.
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ranking = 6
keywords = zygomycosis
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4/36. Rare infections of nose and paranasal sinuses.

    Two cases of fungal infection of the nose and paranasal sinuses by rhinophycomycosis and actinomycosis are reported. The clinical diagnoses in both cases were wrong and in one of them, a malignancy was suspected. These cases are the first to be reported from Central nigeria. The authors feel that fungal granuloma should be included on the differential diagnoses list for patients with swellings of the nose and paranasal sinuses in this environment.
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ranking = 74.767210646592
keywords = phycomycosis
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5/36. Fungal infection associated with intravenous drug abuse: a case of localized cerebral phycomycosis.

    The authors present a case of confusion and mood disturbance caused by a focal cerebral fungal (phycomycosis) infection in an otherwise healthy intravenous drug addict. A review of the literature found only 9 cases of phycomycosis with localized cerebral involvement. This report describes the sixth occurrence of phycomycosis in an intravenous drug addict (the fifth to localize in the basal ganglia). In addition to the human immunodeficiency virus, unusual infectious causes of confusion and mood disturbance may be increasing as the intravenous drug-using population expands. Recognition of the clinical features of a fungal infection in a high-risk population may lead to earlier diagnosis and more effective treatment of this uniformly fatal disease. The clinician should consider localized cerebral phycomycosis as a cause of confusion and mood disturbance in intravenous drug addicts, especially when there is evidence of basal ganglia involvement.
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ranking = 598.13768517274
keywords = phycomycosis
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6/36. Rhinocerebral zygomycosis caused by Saksenaea vasiformis.

    A fatal rhinocerebral zygomycotic infection caused by Saksenaea vasiformis in a 71-year-old man was diagnosed based on the presence of broad, infrequently septate, branched, hyaline hyphae in tissue obtained from the right and left base of the skull, soft tissue, both maxillary sinuses and the sphenoid sinus; isolation of S. vasiformis from the tissue; and demonstration of mucoraceous antibodies by enzyme-linked immunosorbent assay. Fluorescent antibody studies carried out with a rhizopus arrhizus conjugate, stained hyphal fragments in tissue with a 2 intensity.
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ranking = 4
keywords = zygomycosis
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7/36. Intracranial phycomycosis: case reports.

    Cerebral phycomycosis is a rare disease. We describe two patients with unusual features of focal intracranial phycomycosis: a diabetic patient with chronic epidural abscess and a healthy individual with an isolated intracerebral abscess. biopsy established the diagnosis in both patients. Treatment was successful in the patient with intracerebral abscess.
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ranking = 448.60326387955
keywords = phycomycosis
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8/36. Gastrointestinal phycomycosis in acute nonlymphatic leukemia.

    A 37-year-old patient with acute nonlymphatic leukemia developed gastrointestinal phycomycosis during failure in bone marrow production. The clinical presentation was of acute typhlitis. laparotomy revealed a necrotic mass in the region of the iliocecal valve, and on histologic examination hyphae of phycomycetes with invasion of the blood vessels were seen. The patient died as a result of widespread infection.
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ranking = 373.83605323296
keywords = phycomycosis
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9/36. Primary intranasal fusarium infection. Potential for confusion with rhinocerebral zygomycosis.

    fusarium species are saprophytic fungi that may colonize human skin and nails and may rarely cause invasive infections in traumatized tissue and in debilitated and immunocompromised patients. We report herein a case of invasive intranasal fusarium oxysporum infection in a diabetic patient. This unusual presentation potentially can be confused with early rhinocerebral zygomycosis clinically and histologically. Distinguishing morphologic features and the possible role of diabetes in promoting this infection are discussed.
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ranking = 5
keywords = zygomycosis
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10/36. First culture-proven gastrointestinal entermophthoromycosis in the united states: a case report and review of the literature.

    The zygomycosis are fungal infections often occurring in compromised hosts. We report the first culture-proven case of a gastrointestinal infection in the united states by Basidiobolus haptosporus (ranarum). The clinical and histological features are noted in order to distinguish this infection from the more widely reported mucormycosis.
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ranking = 1
keywords = zygomycosis
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