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1/5. adamantinoma and meningioma occurring synchronously in a patient with breast cancer: a case report.

    Screening mammography of a woman with no symptoms led to the diagnosis of carcinoma of the breast, an intracranial meningioma, and adamantinoma of the right tibia. This is the first reported case of three synchronous primary tumors of different tissue origins. biopsy is essential for diagnosing or excluding primary tumor(s) in cases of suspected metastases occurring at a limited number of sites.
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ranking = 1
keywords = tibia
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2/5. Clonal chromosomal abnormalities in osteofibrous dysplasia. Implications for histopathogenesis and its relationship with adamantinoma.

    BACKGROUND. The pathogenesis of osteofibrous dysplasia, a rare fibroosseous lesion occurring almost exclusively in the tibia of children younger than 10 years of age, is not known. One theory is that osteofibrous dysplasia results from excessive resorption of bone with fibrous repair of the defect. Alternatively, osteofibrous dysplasia has been considered a congenital lesion or a variant of fibrous dysplasia. It has been hypothesized that osteofibrous dysplasia is a secondary reactive process to adamantinoma. cytogenetic analysis is one form of investigation that has been instrumental in determining the origin of many disorders. methods. Short-term cultures of two separate osteofibrous dysplasia specimens (approximately 1 year apart) from the tibia of an 11-year-old boy and 2 separate specimens (approximately 2 years apart) from the tibia of a 16-year-old boy were cytogenetically examined using standard procedures. Additionally, fluorescence in situ hybridization (FISH) studies were performed on uncultured cells of both specimens of the first patient using an alpha-satellite probe for chromosome 12. RESULTS. Cytogenetic and FISH analysis revealed trisomy 12 in both specimens of the first patient. trisomy for chromosomes 7, 8, and 22 was seen in both specimens of the second patient. CONCLUSIONS. Osteofibrous dysplasia has not previously been subjected to cytogenetic analysis. trisomy 7 and 12, however, have been reported in a clonally aberrant adamantinoma, potentially providing further support for a relationship between these two lesions. Most importantly, these findings demonstrate a clonal and possibly neoplastic origin for osteofibrous dysplasia of long bone.
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ranking = 3
keywords = tibia
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3/5. adamantinoma of the tibia: MRI documentation.

    We report two cases of adamantinoma of the tibia, for which an MR examination was performed. Each patient was initially investigated with plain radiography and in case 2, a computerized tomography was also performed. The MR characteristics of this tumor are scarcely documented in the even few case reports of this tumor. MRI does not add to the (differential) diagnosis but does have significance in the preoperative staging because it allows adequate delineation of tumor, which is essential for a complete and curative resection of the tumor.
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ranking = 5
keywords = tibia
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4/5. adamantinoma.

    This is an unusual case of an adamantinoma in an early phase of evolution. It was much smaller than adamantinomas typically seen at presentation, although it was located in the usual anterior tibial cortical region. Slow growth and a prolonged period of symptoms are common with adamantinoma and were also observed in this patient. The multifocal presentation within the same bone is unusual. This case illustrated the need to consider adamantinoma in the differential diagnosis of any pre-tibial cortical lesion despite the small size, benign presentation, or the longevity of symptoms.
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ranking = 2
keywords = tibia
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5/5. Osteofibrous dysplasia-like adamantinoma of bone: a report of five cases with immunohistochemical and ultrastructural studies.

    This report describes five cases of osteofibrous dysplasia-like adamantinoma of the tibia in young patients ranging from ages 4 1/2 to 14 years. Radiologically and histologically, these cases were indistinguishable from osteofibrous dysplasia of bone, and no epithelial cells were recognized on routine staining. However, epithelial differentiation was seen in the form of scattered keratin-positive cells in all five cases, and tonofilaments in four cases. The patients were treated by curettage, and three had recurrences. Follow-up showed no progression to classic adamantinoma. Osteofibrous dysplasia-like adamantinoma is a special histological type of adamantinoma that affects children and adolescents. It differs from classic adamantinoma in that it lacks conspicuous nests and masses of epithelial cells, and the prognosis after conservative treatment is generally good. Recent publications suggest that osteofibrous dysplasia-like adamantinoma is a precursor of classic adamantinoma. In a comparative study of three cases of classic adamantinoma, we found, in the fibroblastic stroma of the tumors, spindle epithelial cells that were indistinguishable from the epithelial cells of osteofibrous dysplasia-like adamantinoma. This finding suggests that there is an overlap between these conditions. Four additional cases of osteofibrous dysplasia of the tibia from our files lacked epithelial differentiation. It is most likely that osteofibrous dysplasia is part of the morphologic spectrum of adamantinoma.
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ranking = 2
keywords = tibia
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