Cases reported "Neoplasms, Gonadal Tissue"

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1/20. Use of a long-acting gonadotrophin-releasing hormone analogue in a postmenopausal woman with hyperandrogenism due to a hilus cell tumour.

    OBJECTIVE: The aim of this study was to prove the utility of GnRH analogues for the suppression of androgen secretion in a postmenopausal woman with a suspected virilizing ovarian tumour. DESIGN AND methods: We present a case of a 72-year-old woman with virilization of recent onset. Hormonal studies revealed a fourfold increase in serum testosterone levels, normal dehydroepiandrosterone sulphate concentrations and high levels of serum 17-hydroxyprogesterone levels. Computed axial tomography scan of the ovaries was normal and the adrenal glands showed a discrete enlargement. The long-acting GnRH analogue, triptorelin, was injected initially (3.75mg i.m.) and serum hormone levels were measured weekly throughout one month. RESULTS: GnRH produced a decrease in serum testosterone levels to normal values, in parallel with the suppression of serum LH and FSH concentrations. The patient was treated for three months with triptorelin and she experienced an amelioration of the hyperandrogenic symptoms. In order to achieve a diagnosis, the patient was submitted to a laparotomy that revealed a small hilus cell tumour in the left ovary. CONCLUSION: GnRH analogues may offer a good therapeutic option in some states of gonadotrophin-dependent hyperandrogenism of ovarian origin. ( info)

2/20. Resection of liver metastases from a virilizing steroid (lipoid) cell ovarian tumor.

    The authors report the case of a 34-year-old woman who presented liver metastases from a virilizing lipoid cell ovarian tumor. The patient complained of right upper quadrant abdominal pain, strong virilization and secondary amenorrhea. She developed hirsutism and irregular menses at the age of 23, and a salpingo-ooforectomy for a right ovarian lipoid cell tumor was performed. She was asymptomatic but 6 months before admission she presented abdominal pain. The computed tomography scan showed a large right-side hypodense liver lesion. Tumor and viral markers were normal. serum testosterone was 7 ng/mL and the dehydroepiandrosterone was 2.5 ng/mL. A right trisegmentectomy was performed. Her recovery was uneventful, hormone levels returned to normal, and she has been asymptomatic after a follow-up of 6 months. ( info)

3/20. Sacrococcygeal teratoma: a case report.

    A 23-year old second gravida presented with 8 1/2 months of amenorrhoea. The fundal height corresponded with 36 weeks of pregnancy with a single live foetus. ultrasonography revealed a live foetus and a cystic mass over lower sacral region. Emergency caesarean section was performed and the baby was delivered with intact sacrococcygeal teratoma. The histopathological examination confirmed the diagnosis of sacrococcygeal teratoma with mature neural elements. The baby had died on day 10 and the postpartum period of the mother was uneventful. ( info)

4/20. The steroid profile of a virilizing ovarian tumor.

    A case report of a 25-year-old female with a sex cord stromal virilizing ovarian tumor is presented. The pathway of ovarian steroid secretion in this tumor is elucidated with the dominant elements being pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, androstenedione, and testosterone. The tumor primarily made testosterone (T) with lesser elevations of androstenedione (A), dehydroepiandrosterone (DHEA), and dihydrotestosterone (DHT). Expert pathologic opinions differed whether this neoplasm was a Sertoli-Leydig tumor or a virilizing granulosa tumor; therefore, it was probably a gynandroblastoma. A unilateral salpingo-oophorectomy was performed and the patient promptly resumed normal ovarian function with ovulation. ( info)

5/20. A steroid cell tumor outside the ovary is a rare cause of virilization.

    OBJECTIVE: To report the case of a female who presented in childhood with symptoms and signs of hyperandrogenism secondary to an extraovarian steroid cell tumor. DESIGN: Case report. SETTING: Endocrine investigation unit of a university teaching hospital. PATIENT(S): An 11-year-old female presented with symptoms and signs of hyperandrogenism. INTERVENTION(S): ultrasonography, MRI imaging, bilateral adrenal and ovarian venous sampling, laparoscopy, and laparotomy. MAIN OUTCOME MEASURE(S): ultrasonography, laboratory tests. RESULT(S): hyperandrogenism was due to an extraovarian steroid cell tumor located in the broad ligament. The tumor was successfully removed at laparotomy with biochemical and clinical resolution of the hyperandrogenism. CONCLUSION(S): Extraovarian steroid cell tumor is a rare cause of hyperandrogenism. ( info)

6/20. Gynandroblastoma of the ovary. A case report.

    An ovarian gynandroblastoma was found in a 59-year-old woman. The tumor consisting of mixed Sertoli-leydig cells and granulosa-theca cells demonstrated no malignant features. Bisexual cells in gynandroblastoma derived from a common gonadal mesenchyme precursor or indifferent cell. The excision of appendages with tumor or hysterectomy was sufficient. ( info)

7/20. Gynandroblastoma of the ovary having a typical morphological appearance: a case study.

    A rare gynandroblastoma of the right ovary with a typical morphological appearance in a 65-year-old woman is reported. The tumor comprised both a granulosa cell element with a Call-Exner body and a Sertoli cell element. Pathologically, this case could be the most typical of all the world's established cases. Clinically, there were feminizing symptoms such as post-menopausal genital bleeding and endometrial cystic hyperplasia. Pre-operative serum hormonal assays indicated elevated levels of estrone, estradiol and testosterone, and low levels of gonadotropins. These returned to normal after surgery. ( info)

8/20. Gynandroblastoma of the ovary.

    Gynandroblastoma is an extremely rare primary tumour of the ovary showing morphological evidence of both male and female differentiation. We describe the light and ultrastructural features of this tumour and review the present knowledge about its nature, function and behaviour. ( info)

9/20. granulosa cell tumor of the ovary with sertoli-leydig cell tumor components (gynandroblastoma).

    A rare granulosa cell tumor with sertoli-leydig cell tumor components (gynandroblastoma) arising in the left ovary was reported in a 63-year-old female. Microscopically, the tumor was composed predominantly of granulosa cells arranged mainly in a diffuse solid pattern, but in some areas there were a trabecular pattern and thecofibromatous stromal components. Also, well-differentiated sertoli-leydig cell tumor elements were present as a minor component. The tumor produced, endocrinologically, a large amount of estradiol, some androstenedione and a small amount of testosterone. The possibility that estradiol in the present tumor was produced predominantly from androstenedione via estrone was suggested by the results of an in vitro biosynthetic study. ( info)

10/20. Gynandroblastoma of the ovary.

    A left ovarian gynandroblastoma in a 24-year-old woman was clinically manifest by prolonged (7 years) amenorrheas interrupted by metrorrhagies, with moderate hypertrichosis is presented. An important urinary elimination of estrogens (1.500 gamma/24 h) and of 17-ketosteroids (25 gamma/24 h) with normal 17-OH and gonadotrophins were evidenced. The microscopic examination of the operated tumor showed structures of a granulous tumor intermingled with arrhenoblastomatous structures. Restoration of the patient's sexual biological conditions. ( info)
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