11/12. Course of Henoch-Schonlein nephritis after renal transplantation. Report on ten patients and review of the literature.The frequency and the risk factors for clinical recurrence of Henoch-Schonlein nephritis following renal transplantation (TP) remain largely unknown. We report on 14 transplants performed at our center in 10 patients, detail the evolution of 2 of them with clinical recurrence, and review 64 other transplants reported in the literature. In our series, all patients are currently alive. Seven grafts are well-functioning 22-295 (mean, 97) months after TP without any sign of clinical recurrence. Five grafts were lost from rejection. Clinical recurrence occurred in 2 patients who were on cyclosporine/azathioprine/prednisone therapy. Pooling our series with that of Hasegawa et al., the actuarial risk for renal recurrence and for graft loss due to recurrence was 35 and 11% at 5 years after TP, respectively. In our series, duration of original disease was 2 and 28 months in the 2 patients with recurrence versus 31-144 months in the others without recurrence. In the literature, this duration was < or = 36 months in all 7 patients with recurrence. recurrence occurred despite a > 12-month delay between disappearance of purpura and TP in our 2 patients and in 3 of 6 previously reported recurrences. We conclude that Henoch-Schonlein purpura nephritis frequently recurs after TP. recurrence (1) seems to be associated with a shorter duration of the original disease, (2) can occur despite a delay of more than 1 year (as commonly advised) between disappearance of purpura and TP, and (3) is not prevented by a triple immunosuppressive regimen that includes cyclosporine.- - - - - - - - - - ranking = 1keywords = purpura (Clic here for more details about this article) |
12/12. Urologic manifestations of Henoch-Schonlein purpura.Henoch-Schonlein purpura involves the kidneys in about 50 per cent of cases. In adults the classic signs are usually absent. Open renal biopsy is valuable from a prognostic standpoint since the severity of the renal lesion can be correlated with the future clinical course.- - - - - - - - - - ranking = 1.6666666666667keywords = purpura (Clic here for more details about this article) |
| <- Previous | |