Cases reported "Nephroma, Mesoblastic"

Filter by keywords:



Filtering documents. Please wait...

1/2. Congenital mesoblastic nephroma: report of a Case with review of the most significant literature.

    AIMS AND BACKGROUND: Congenital mesoblastic nephroma (CMN) is a rare pediatric tumor of the kidney with the highest peak of incidence during the first 3 postnatal months. It has previously been confused with Wilms' tumor (which, on the contrary, is rare during the first six months of age and is still considered a histogenetic congener). CMN almost always has a favourable prognosis. Therefore, CMN needs to be correctly diagnosed and differentiated from other pediatric renal neoplasms. Two morphological subtypes are currently distinguished histologically: the classical or leiomyomatous type and the atypical or cellular type. Mixed forms with a combination of the two patterns are also on record. recurrence and even tumor-related death have been described in the literature and always related to the atypical form or to the mixed form, particularly in patients aged more than 3 months and in those cases in which the surgical removal was not complete. Opinions concerning post-surgical clinical management, especially in regard to adjuvant therapy, are not unanimous. methods: A case of CMN, predominantly of the classical histological subtype diagnosed in a baby with a follow-up of 6 years, is herein presented. The tumor was discovered at birth and surgically removed after one month. Since the tumor showed a high mitotic index (one of the characteristics of the cellular subtype) and the perirenal fat was focally involved with the tumor, the possibility of giving adjuvant chemotherapy was considered. Flow cytometric analysis was also performed which showed a diploid dna content of neoplastic cells. RESULTS: The tumor was completely removed, surgical margins were free histologically, and no clear-cut histological features of the atypical subtype were noted. Flow cytometrically, it showed the euploid dna content. Consequently no additional therapy was given. Six years after surgery the patient is developing well and is free of disease. He has regular follow-up examinations. CONCLUSIONS: CMN almost always pursues a benign clinical course if diagnosed under three months of age and if totally surgically excised independent of histological type. Criteria for management of atypical cases are not unanimous in regard to the benefit of additional therapy after surgery.
- - - - - - - - - -
ranking = 1
keywords = prognosis
(Clic here for more details about this article)

2/2. Perinephric cystic mesoblastic nephroma complicated by hepatic metastases: a case report.

    Congenital mesoblastic nephroma (CMN) is a well-recognised renal tumour presenting in infancy, which has an excellent prognosis if completely excised. We describe the imaging appearances of an unusual, predominantly perinephric cystic CMN, with relative renal preservation but with retroperitoneal extension and bowel infiltration, which was complicated by hepatic metastases. To our knowledge, neither the appearance of the primary tumour nor the subsequent development of hepatic metastases has previously been reported. This appearance may represent a poor prognostic indicator for outcome. However, following partial hepatectomy, the patient remains disease-free at 1 year.
- - - - - - - - - -
ranking = 1
keywords = prognosis
(Clic here for more details about this article)


Leave a message about 'Nephroma, Mesoblastic'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.