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1/59. pregnancy-associated melanoma occurring in two generations.

    We report of a case of malignant melanoma occurring during pregnancy in a woman whose mother had a melanoma excised during pregnancy. There was no other family history of melanoma. To our knowledge, this has not been previously reported. A review of the recent literature suggests that pregnant women with melanoma do not have a worse prognosis when compared to matched controls, but may present with worse prognostic features.
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ranking = 1
keywords = melanoma, malignant melanoma
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2/59. Malignant melanoma in a skin graft: burn scar neoplasm or a transferred melanoma?

    Malignant melanomas (MM) arising in burn scars are rare with 16 cases previously reported. Malignant melanomas arising on skin grafts are even more rare with only two cases reported. We present the case of MM arising on a burned area that had been previously grafted with a split thickness skin graft. A 19-year-old patient sustained 20% burns in a road traffic accident. The burned areas were debrided and skin grafted. Six months later, the patient developed MM on the left calf (an area that was burned and grafted). The tumour was excised with wide margins. Six months following the excision of the MM, the patient started to develop multiple dysplastic naevi in the skin grafted burned areas. In the present case, the main question to be answered is whether the MM arose from the donor or the recipient site of the split thickness skin graft. After thorough discussion of the two options and reviewing the literature, the authors believe that the MM and the atypical naevi were transferred to the recipient site with the skin graft. Therefore, it is suggested that in the process of harvesting skin grafts, any pre-existing naevi should be avoided or removed, and if this is not feasible, should be recorded in detail in the operation notes. Also, patients at discharge should be advised that any change in the appearance of the grafts or any new lesions in the engrafted areas should be reported to their physicians.
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ranking = 1.1553293649777
keywords = melanoma
(Clic here for more details about this article)

3/59. Nevi and melanoma: lessons from Turner's syndrome.

    Females with Turner's syndrome (TS) have a markedly increased number of cutaneous nevi. While this is a well-recognized risk factor for cutaneous melanoma (CM), the incidence of this tumor in TS and the implications for our understanding of nevi and melanoma have not previously been considered. Here we report a case of an anorectal melanoma in a woman with TS and a review of the literature. overall, there appears to be a lower than expected incidence of CM. Possible explanations are discussed and in particular the possible relationship between sex hormones and melanoma development as these girls fail to undergo normal pubertal development. Further study of this syndrome may provide important insights into the genetic factors involved in normal melanocyte and nevus development, the potential influence of sex hormones on melanoma development and the relationship between the presence of nevi and the risk of developing CM.
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ranking = 1.0397964284799
keywords = melanoma
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4/59. Amelanotic choroidal nevus and melanoma: cytology, tumor size, and pigmentation as prognostic indicators.

    BACKGROUND: Choroidal nevi are fairly common lesions of the posterior pole that can sometimes transform into melanoma, and it is thought that most choroidal melanomas arise from preexisting nevi. Occasionally, these lesions present as nonpigmented or amelanotic variations of their pigmented counterparts. Recent studies suggest a relationship between tumor pigmentation and risk of growth and metastasis, with a better prognosis for lightly pigmented or amelanotic lesions. case reports: A case of an amelanotic choroidal nevus and melanoma are presented. In Case 1, a 26-year-old white female was found to have a large amelanotic nevus in the right eye. After 7 years of periodic observation, the lesion has not changed. In Case 2, a 51-year-old white male was diagnosed with a large amelanotic melanoma in the left eye. Due to extensive involvement of the optic nerve, the patient underwent enucleation. Histological evaluation confirmed the lesion as a mixed-cell type malignant amelanotic melanoma. CONCLUSION: Management of choroidal nevi generally consists of periodic observation, and the most widely accepted management of choroidal melanoma is observation, radiotherapy, and transpupillary thermotherapy or enucleation. The therapeutic modality of choice for melanoma will vary depending on the size, growth, and location of the lesion. In addition, recent studies suggest an association between heavy tumor pigmentation, tumor size, cell type, and risk of metastasis. Although many variables will influence the final treatment option, pigmentation of the lesion should also be considered.
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ranking = 1.2708623014755
keywords = melanoma
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5/59. Seborrheic keratosis with compound nevus, junctional nevus and basal cell carcinoma in the same lesion.

    Seborrheic keratosis can be associated with different neoplasms such as basal cell carcinomas, squamous cell carcinomas and melanomas. We describe an unusual case of a man who presented with a brown plaque on his back. The clinical diagnosis was melanoma. Histopathologic examination of the lesion revealed four neoplasms: a compound nevus, a junctional nevus, a superficial basal cell carcinoma and a seborrheic keratosis. Although this association most likely represents a chance phenomenon, we discuss the possibility that the seborrheic keratosis developed from the nevus, and that subsequently the junctional nevus and the basal cell carcinoma developed from the seborrheic keratosis.
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ranking = 0.23106587299554
keywords = melanoma
(Clic here for more details about this article)

6/59. Two cases of melanose neurocutanee with development of malignant melanoma: a microspectrophotometric and electron microscopic study.

    Two cases of neurocutaneous melanosis with development of malignant melanoma in the Japanese are presented. The first case was a 4-year-old boy in whom a retroperitoneal melanoma appeared with giant nevi, and cerebral and spinal melanosis. The second case was a 39-year-old man, in whom a primary leptomeningeal melanoma developed with leptomeningeal melanosis and smaller pigmented nevi. Microspectrophotometric and electron microscopic studies were made on the neoplastic and non-neoplastic melanotic tissues to elucidate the histogenesis of this rare disorder. Two different patterns of nuclear dna histograms, corresponding to melanosis and melanoma, were obtained by microspectrophotometry, Considerable variation in the ultrastructure of the melanocytes was seen by electron microscopy.
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ranking = 1.3029460320713
keywords = melanoma, malignant melanoma
(Clic here for more details about this article)

7/59. Focus on primary care: from nevus to neoplasm: myths of melanoma in pregnancy.

    Malignant melanoma is one of the few malignancies that regularly affect women during their childbearing years. Additionally, the incidence of melanoma has been increasing over the last several decades. early diagnosis of stage I disease may lead to curative therapy; thus it is important for physicians and midwives to do a full examination of the skin. However, the myth that nevi may naturally grow or change during pregnancy has been shown not to be true and should not delay a diagnostic evaluation of a suspicious nevus. Older studies had theorized a worse outcome for pregnant women with melanoma. However, multiple controlled series and investigations have found that stage for stage this cancer is not affected adversely by pregnancy. prognosis, recurrence, and incidence of melanoma seemed to be unaffected. Estrogen-containing oral contraceptives, as well as hormone replacement therapy, have no adverse affect on the disease.
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ranking = 0.92426349198216
keywords = melanoma
(Clic here for more details about this article)

8/59. Broad spectrum of leukoderma acquisitum centrifugum.

    A series of diverse neuroectodermally derived tumors associated with halos of leukoderma is presented. Clinically these lesions have in common a centrally placed, usually pigmented tumor encircled by a zone of hypopigmentation. The histological findings include (1) reduction or absence of epidermal melanin, but persistence of amelanotic melanocytes in the leukodermic halo; (2) a variety of tumors including nevus-cell nevus, neuroid nevus, blue nevus, neurofibroma, and malignant melanoma; (3) variable numbers of "small dark cells" whose nature is unclear, and which probably represent in part small nevus cells and in part lymphoid cells; and (4) damage to some tumor cells which presumably could be the cause of their destruction. Also presented are histochemical demonstrations of tyrosinase activity and immunohistochemical studies for presence of gamma-globulin in the tumors. Using the fluorescent antibody technique it was not possible to show gamma-globulins in patients' sera directed against their tumors. The relationship of developing hypopigmentation to the spontaneous regression of cutaneous neuroectodermally derived tumors is discussed.
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ranking = 0.19126944451561
keywords = melanoma, malignant melanoma
(Clic here for more details about this article)

9/59. "connective tissue nevus" and a serendipitous S-100 discovery.

    Although desmoplastic melanoma is classically described as an indurated nodule on the head of an elderly patient associated with the histologic changes of an atypical intraepidermal melanocytic lesion accompanied by abnormal dermal spindled cells and rounded lymphoid infiltrates, it is capable of presenting in a variety of clinical and pathologic guises. Herein, a case with unusual clinical and histologic attributes is reported, which was initially misdiagnosed as a connective tissue nevus.
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ranking = 0.11553293649777
keywords = melanoma
(Clic here for more details about this article)

10/59. Malignant melanoma arising in a sebaceous nevus of the scalp.

    This is the first report of malignant melanoma arising from sebaceous nevus (SN) of the scalp, although it has been known that various benign and malignant neoplasms may develop in association with SN. After the excisional biopsy for SN with 5 mm free margin, pathological examination revealed the coexistence of nodular melanoma invading to the reticular dermis (IV level of Clark) for a maximal depth of 4 mm. After resection with another 20 mm free margin, there has been no evidence of local recurrence or distant metastasis for nine years.
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ranking = 0.76893412700446
keywords = melanoma, malignant melanoma
(Clic here for more details about this article)
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