Cases reported "Nevus of Ota"

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1/13. Choroidal melanoma with oculodermal melanocytosis in Hispanic patients.

    PURPOSE: To describe three Hispanic patients with oculodermal melanocytosis and uveal melanoma. METHOD: Case series. RESULTS: Three Hispanic patients with oculodermal melanocytosis and uveal melanoma underwent enucleation. The diagnosis of choroidal melanoma was confirmed by histopathologic examination. CONCLUSION: In the Hispanic population, uveal melanoma can occur in the presence of oculodermal melanocytosis.
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ranking = 1
keywords = melanoma
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2/13. magnetic resonance imaging in cavitary choroidal melanoma.

    PURPOSE: To report the development of a cavitary choroidal melanoma in a patient with nevus of ota and describe its magnetic resonance imaging (MRI) features. PATIENT: A 66-year-old man with right oculodermal melanocytosis and an ipsilateral choroidal cavitary melanoma was seen. diagnosis was suspected on the clinical, ultrasonographic and MRI findings. RESULTS: T1-weighted image showed a hyperintense solid mass containing hypointense cystic-like spaces delineated by hyperintense septa with respect to the vitreous. The reverse image was observed on T2-weighted images. A choroidal melanoma comprising epithelioid and spindle cells with multilocular cavities was documented histopathologically. CONCLUSIONS: There may be an association between cavitary melanoma and nevus of ota. Characteristic MRI findings could be helpful in the differential diagnosis of cavitary uveal melanoma.
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ranking = 1.125
keywords = melanoma
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3/13. Neurocutaneous melanosis: a case of primary intracranial melanoma with metastasis.

    Neurocutaneous melanosis is a rare disorder characterized by the presence of large or multiple congenital melanocytic naevi and benign or malignant pigment cell tumours of the leptomeninges. Distant metastasis is unusual in primary leptomeningeal/intracranial melanomas. We present the case history of an adult male who had multiple primary intracranial melanomas associated with neurocutaneous melanosis (naevus of Ota) in the ophthalmic division of the left trigeminal nerve. Excision of the intracranial tumours was carried out in two stages, but the patient died 2 days after the second operation. autopsy showed multiple metastatic deposits in the liver. Symptoms and signs of raised intracranial pressure, the presence of Ota's naevus, and a dural-based mass or masses should alert the treating physician to suspect a primary leptomeningeal/intracranial melanoma.
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ranking = 0.875
keywords = melanoma
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4/13. Intracranial meningeal melanocytoma associated with ipsilateral nevus of ota. Case report.

    In this report, the authors review the case of a man with a neurocutaneous syndrome. He presented with an intracerebral melanocytoma associated with a blue nevus of the scalp; its location and its appearance during childhood supported the diagnosis of a nevus of ota. Meningeal melanocytomas are increasingly being diagnosed, but remain rare. Primary meningeal malignant melanoma is the first differential diagnosis to eliminate. Despite their common embryonic origin. the association of a melanocytoma with a nevus of ota is rare. A nevus of ota exhibits the same melanocytic proliferation and affects the trigeminal nerve territory. An ocular effect is not always observed. In contrast to an ocular lesion, a nevus of ota rarely transforms into a malignant melanoma. It is found only among caucasians. During 4 years of follow-up review after surgery, the patient remained asymptomatic. Other than antiepileptic therapy, he received no complementary treatment and cerebral imaging revealed no evidence of recurrence.
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ranking = 0.49114756434657
keywords = melanoma, malignant melanoma
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5/13. Malignant melanoma in a Hispanic male with nevus of ota.

    nevus of ota is uncommon in the non-Oriental population. We report a case of malignant melanoma with metastasis to the genitourinary tract in a Hispanic male with nevus of ota. Thirty-six prior cases of nevus of ota with malignant melanoma reported in the English language are reviewed. Sixty-eight percent were women; 76% were Caucasians. Metastatic disease was reported in 16%. Three patients had liver metastases. Our case was the first involving the genitourinary tract. All but one patient with metastatic disease died within 1 month of presentation. Despite the increased frequency of nevus of ota in the Japanese, only 4 cases of malignant melanoma have been reported. nevus of ota would appear to be a risk factor for developing malignant melanoma in the Caucasian population.
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ranking = 1.4822951286931
keywords = melanoma, malignant melanoma
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6/13. Bilateral naevus of Ota: a rare manifestation in a Caucasian.

    The naevus of Ota (naevus fusculocoeruleus ophthalmomaxillaris) was first described by the Japanese dermatologist M. T. Ota in 1939. It has a reported incidence of 0.2% to 1% in the Japanese population. It usually occurs in the skin innervated by the first or second branch of the trigeminal nerve. The naevus comprises dermal melanocytes and is congenital or acquired during adolescence. Commonly associated lesions include scleral melanocytosis and other ocular manifestations as well as lesions of the tympanic membrane, oral and intranasal mucosa and leptomeninges. Diseases associated with Ota's naevus in rare cases are open-angle glaucomas and melanoma. The naevus of Ota in Europeans is a rare manifestation. We report the very rare case of a bilateral naevus of Ota associated with enoral melanocytosis in a white European person.
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ranking = 0.125
keywords = melanoma
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7/13. Oculodermal melanocytosis--nevus of ota (with palatal pigmentation).

    nevus of ota is a benign dermal melanocytosis, that involves facial skin as a macular discoloration, appearing as blotchy blue to blue gray. It involves the upper portion of the face, especially over the periorbital area. It also involves ocular structures such as episclera, sclera, conjunctiva, cornea, retina, uveal tract and also nasopharynx, auricular mucosa, tymphanic membrane and dura. glaucoma and malignant melanoma are the two known ocular complications in patients with nevus of ota. 12-18% of these patients exhibits palatal pigmentation. Here we are reporting two cases of Oculodermal melanocytosis, one of which exhibited palatal pigmentation.
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ranking = 0.24557378217328
keywords = melanoma, malignant melanoma
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8/13. Flipped scleral flap surgery for reduction of ocular pigmentation in oculodermal melanosis.

    PURPOSE: To report on surgical reduction of oculodermal melanosis in 6 patients presenting with severe episcleral pigmentation. methods: After informed consent was obtained, surgical reduction of ocular pigmentation with ocular dermal melanosis was performed on 3 children, 2 girls and 1 boy male, who were cosmetically handicapped. After conjunctival peritomy, rectangular scleral free flaps were created using lamellar dissection, usually in the nasal or temporal quadrants. The rectangles extended from just posterior to the rectus muscle insertion. These free flaps were flipped over and reattached to the scleral bed, hiding the episcleral pigmentation internally and resulting in a less pigmented surface being visible. The superficial scleral nevus and the nevus adjacent to the limbus were peeled using a blade. RESULTS: In all cases, episcleral pigmentation was reduced with satisfactory cosmetic improvement, but mild scleral pigmentation and conjunctival scarring remained. During the 37-month mean follow-up period, no complications were observed. CONCLUSIONS: patients with oculodermal melanosis often complain of globe pigmentation as well as face pigmentation. Serial follow-up was needed because some reports indicate development of choroidal melanoma occurs in oculodermal melanosis. To the best of our knowledge, this is the first report of successful surgical reduction of ocular pigmentation in oculodermal melanosis.
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ranking = 0.125
keywords = melanoma
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9/13. Diffuse iris nevus in oculodermal melanocytosis: a light and electron microscopic study.

    We studied by light and electron microscopy the diffuse iris nevus of an eye in a 16-year-old patient with oculodermal melanocytosis and choroidal malignant melanoma. The nevus cells in the anterior border layer of the iris appeared to be poorly differentiated, showing moderate infolding of the nuclear membrane with heterochromatin clumping, watery cytoplasm, abundant mitochondria, fine filaments, rough endoplasmic reticulum, and numerous pinocytotic vesicles. Small scattered immature melanosomes and occasional giant melanosomes were observed in these cells. Deep in the iris stroma, however, nevus cells were found singly or in small groups, and were associated with an increasing number of melanized melanosomes and cytoplasmic filaments and reduced numbers of other cytoplasmic organelles, such as mitochondria and free ribosomes. Differentiation of the iris nevus cells appeared to progress from the anterior border layer toward the iris stroma. This observation suggests that intrastromal nevi may be more benign than nevi with surface plaque. The ultrastructural characteristics of the diffuse nevi of oculodermal melanocytosis were compared with those of other iris nevi.
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ranking = 0.24557378217328
keywords = melanoma, malignant melanoma
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10/13. Malignant melanoma of the choroid in a naevus of Ota.

    A rare case of choroidal malignant melanoma in a naevus of Ota is described. This is the first reported case from asia outside the Japanese population. This case illustrates the need for close observation of all pigmented lesions of the eye.
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ranking = 0.74557378217328
keywords = melanoma, malignant melanoma
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