1/10. Anterior ischaemic optic neuropathy in a patient with optic disc drusen.BACKGROUND: Although visual field defects are well-known complications of optic disc drusen, reduction in visual acuity with this condition is rare. METHOD/RESULTS: We report on a 68-year-old male with bilateral optic disc drusen who presented with monocular loss of vision in the right eye associated with an inferior altitudinal visual field defect and signs consistent with acute anterior ischaemic optic neuropathy, confirmed on fluorescein angiography. He also had a left inferior nasal step, but no evidence of glaucomatous cupping. The disc drusen were documented clinically and on B scan ultrasound and computed tomography. CONCLUSIONS: The diagnosis of acute anterior ischaemic optic neuropathy should be considered in patients with optic disc drusen who present with reduced visual acuity, particularly when the visual loss has been acute and non-progressive and is associated with altitudinal field loss and characteristic fluorescein angiography signs.- - - - - - - - - - ranking = 1keywords = neuropathy (Clic here for more details about this article) |
2/10. Optic neuropathy following amiodarone therapy.Ocular changes during treatment with amiodarone are almost universal but are rarely serious. In this article we describe three patients from a single electrophysiology practice in whom optic neuropathy developed during treatment with amiodarone. All three patients were more than 65 years of age. The doses of amiodarone ranged from 100 to 400 mg/day, and the time intervals between the initiation of the amiodarone therapy and the appearance of first symptoms of optic neuropathy were 5 to 19 months. Two patients had bilateral involvement, and one had only unilateral involvement. Whether this result was due solely to amiodarone therapy, to the underlying poor health of these patients, or to the combination of these two factors is uncertain. These findings prompt us to recommend that all patients who receive amiodarone undergo complete ophthalmologic examinations, including careful evaluation of the ocular fundus regularly during such therapy. No randomized study had been undertaken to determine the true incidence of complications associated with this medication.- - - - - - - - - - ranking = 1keywords = neuropathy (Clic here for more details about this article) |
3/10. Bilateral anterior ischaemic optic neuropathy due to optic disc drusen.PURPOSE: To report a case of bilateral anterior ischaemic optic neuropathy due to buried optic disc drusen. methods: Case report. RESULTS: A 64-year-old man presented with swollen optic discs and features suggestive of anterior ischaemic optic neuropathy (AION) in the left and right eye on two separate occasions ten months apart. Detailed ocular examination at presentation and systemic investigations did not reveal an underlying cause for the AION. At a later follow-up, optic disc drusen were noted in both eyes as partial optic atrophy had set in. This was confirmed by ultrasound B scan and demonstration of autofluorescence. CONCLUSIONS: In patients presenting with AION uncommon underlying causes must be considered. Routine ultrasound B scan at presentation can easily establish or exclude optic disc drusen as an underlying cause.- - - - - - - - - - ranking = 1keywords = neuropathy (Clic here for more details about this article) |
4/10. I don't need my glasses, but...A 24-year old man complained of decreased vision in his right eye for 1 week. Examination revealed a subtle right optic neuropathy. Fundoscopy showed bilateral buried drusen, which were confirmed with B-scan ultrasonography. An MRI was normal.- - - - - - - - - - ranking = 0.16666666666667keywords = neuropathy (Clic here for more details about this article) |
5/10. optic disk drusen, peripapillary choroidal neovascularization, and poems syndrome.PURPOSE: To report the case of a 64-year-old woman with peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, Castleman disease, optic nerve drusen, and peripapillary choroidal neovascularization. methods: Interventional case report. Clinical practice. RESULTS: Laser photocoagulation resolved the peripapillary choroidal neovascularization. CONCLUSION: This is the first documented case of optic disk drusen and peripapillary choroidal neovascularization associated with POEMS.- - - - - - - - - - ranking = 0.16666666666667keywords = neuropathy (Clic here for more details about this article) |
6/10. Anterior ischemic optic neuropathy in eyes with optic disc drusen.BACKGROUND: There have been anecdotal reports of anterior ischemic optic neuropathy (AION) occurring in eyes with optic disc drusen (ODD), but the clinical features of this condition have not been well characterized. OBJECTIVES: To better describe the clinical features of AION associated with ODD and to compare the clinical features of this condition with those of "garden variety" nonarteritic AION. methods: We reviewed the medical records of 20 patients who experienced an episode of AION in an eye with ODD. In 4 patients, both eyes were affected; thus, 24 eyes were studied. The diagnosis of ODD was made by ophthalmoscopic identification, orbital ultrasonography, or computed tomographic scanning. We recorded age, sex, vascular risk factors, symptoms, visual acuity, visual fields, and results of the follow-up examination in all patients. These findings were compared with data from previously reported series of patients with nonarteritic AION. RESULTS: Our 20 patients included 14 men and 6 women (age range, 18-69 years; mean, 49.4 years). Vascular risk factors were identified in 10 patients (50%). Three patients reported episodes of transient visual loss before their fixed deficit. The visual acuity at the initial examination was 20/60 or better in 15 (62%) of the 24 eyes; 8 had a visual acuity of 20/20. The predominant pattern of visual field loss was an altitudinal or arcuate defect in 19 (79%) and a centrocecal scotoma in 5 (21%) of the 24 eyes. There was subjective worsening of vision before the initial neuro-ophthalmic examination in 11 eyes (46%) and objective documentation of progression in 7 eyes (29%). The final visual acuity was 20/40 or better in 13 (62%) of 21 eyes and 20/200 or worse in 3 (14%) of 21 eyes. CONCLUSIONS: Our patients were strikingly similar to those with nonarteritic AION unassociated with drusen in regard to prevalence of vascular risk factors, pattern of visual field loss, and occurrence of a subsequent similar event in the fellow eye. In contrast, however, patients with ODD-AION were younger than those with nonarteritic AION, were more likely to report preceding episodes of transient visual obscuration, and enjoyed a more favorable visual outcome.- - - - - - - - - - ranking = 0.83333333333333keywords = neuropathy (Clic here for more details about this article) |
7/10. Optic disc drusen in tilted disc.PURPOSE: To investigate if a congenital anomaly of the head of the optic nerve like such as tilted disc can be a risk factor for the development of optic disc drusen. methods: The study was performed retrospectively on the files of 47 patients with optic disc drusen. The diagnosis was confirmed by fluorescein angiography and B-scan ultrasonography. The authors examined the fundus photographs and the fluorescein angiographies of these patients looking for the presence of tilted discs. RESULTS: Two of the 47 patients with optic nerve drusen had tilted discs as well, about twice the expected rate. Both cases presented a parapapillary hemorrhage. CONCLUSIONS: The concomitant presence of tilted disc and optic disc drusen can have a cause-effect relationship. The axonal crowding in a scleral canal of reduced size, as seen in tilted disc, can compress the nerve fibers against the stiff lamina cribrosa, producing a chronic optic neuropathy leading to drusen.- - - - - - - - - - ranking = 0.16666666666667keywords = neuropathy (Clic here for more details about this article) |
8/10. Bilateral anterior ischaemic optic neuropathy associated with optic disc drusen and systemic hypotension.We report a case of bilateral anterior ischaemic optic neuropathy in a 23-year-old woman which was probably attributable to optic disc drusen and systemic hypotension related to peritoneal dialysis for renal failure.- - - - - - - - - - ranking = 0.83333333333333keywords = neuropathy (Clic here for more details about this article) |
9/10. Optic disc drusen and associated venous stasis retinopathy.methods: Optic disc drusen is not an uncommon diagnosis in clinical ophthalmic practice. Although associated complications are quite rare, they may be visually devastating. Complications include optic neuropathy and hemorrhagic retinopathy. A case report of extensive optic disc drusen with associated venous stasis retinopathy is presented. RESULTS: Long-term follow up showed increasing venous stasis retinopathy secondary to optic disc drusen. Cystoid macular edema formed that gradually decreased vision from 20/20 to 20/70. CONCLUSIONS: Although infrequent, complications of optic disc drusen can be visually devastating. There is no treatment for disc drusen, but some of the complications may be amenable to treatment.- - - - - - - - - - ranking = 0.16666666666667keywords = neuropathy (Clic here for more details about this article) |
10/10. Sudden visual field constriction associated with optic disc drusen.We report two patients with optic disc drusen who suffered sudden, concentric constriction of the visual field. visual acuity remained normal. The involved discs showed no swelling, hemorrhage, or other evidence of anterior ischemic optic neuropathy. We are unable to explain the mechanism or the pattern of visual field loss in these unusual cases.- - - - - - - - - - ranking = 0.16666666666667keywords = neuropathy (Clic here for more details about this article) |
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