Cases reported "Orbital Diseases"

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11/17. Subacute zygomycosis of the orbit.

    A zygomycotic (phycomycotic) orbital cellulitis developed in a healthy 9-year-old boy. Because of the involved tissue's unfamiliar histopathologic features, an initial diagnosis of eosinophilic granuloma was made and appropriate treatment was delayed for more than six months. The patient's slowly progressive form of zygomycosis was clinically and morphologically similar to that described in previously recorded cases. All three cases occurred in otherwise healthy children living within the united states. Their involved tissues had mixed histopathologic features of chronic granulomatous entomophthoramycosis and acute necrotizing mucormycosis; however, unlike entomophthoramycosis, the fungi in these cases may invade the walls of blood vessels and cause severe tissue necrosis. We believe that these three cases represent a distinct clinicopathologic variant of facial-cranial zygomycosis not previously delineated in the literature. Although they are aggressive, these infections are not as fulminant as in classic mucormycosis, but can nevertheless be lethal.
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keywords = zygomycosis
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12/17. Orbital phycomycosis.

    3 cases with rhinoorbital phycomycosis and a 4th case, in which it was considered retrospectively, are presented in hematological patients. 2 of the 4 patients survived. In the first 3 cases, which appeared in a period of 2 months in the hematology Unit, an epidemiological study was made, showing that the cause of the infections was contamination of the air-conditioning systems of this unit by numerous Phycomycetes and Mucor pusillus.
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ranking = 2.3249311636683
keywords = phycomycosis
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13/17. Rhino-orbital phycomycosis complicated by cerebral abscess.

    The incidence of phycomicosis has increased in the last decades. Its diagnosis is very difficult and usually not established ante morten. Early treatment is of crucial importance, because despite the antifungal drugs, the mortality rate remains around 80%. The present report describes a successfully treated diabetic patient with a rhino-orbital form of the disease and an unusual complication--a cerebral abscess--in whom the clinical diagnosis was supported by the CT findings.
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ranking = 1.8599449309346
keywords = phycomycosis
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14/17. Cephalic phycomycosis: a report of eight cases.

    Phycomycosis is the preferred terminology to define a fungal disease which may be devastating and fatal. It is caused by a nonseptate hyphae, class phycomycetes and genus (rhizopus, Mucor, absidia). Phycomycosis in man is usually associated with debilitating diseases such as: diabetes mellitus, leukemia and immunosuppressive conditions. The cephalic phycomycosis has two forms: 1. rhino-orbital cerebral which may be fatal, and 2. rhino-paranasal sinuses form which usually has a benign clinical course. From 1943 to 1967, only 45 cases of the cephalic form were described with a mortality rate of 50%. Since then several series have been added to the literature with improved survival, probably due to the addition of amphotericin b to the therapy. Even with modern therapy, the mortality rate is still about 30%. Modern technology C.T. scan is very helpful to establish orbital and intracranial extension. When intracranial involvement is present, the prognosis is dismal. Our series of 8 patients is reported.
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ranking = 2.3249311636683
keywords = phycomycosis
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15/17. zygomycosis orbital apex syndrome in association with a solitary lung carcinoma.

    We describe a patient who presented with orbital apex syndrome. Sphenoidectomy and biopsy revealed invasive zygomycosis. The patient had no obvious risk factors for the development of zygomycosis, but was subsequently found to have a solitary, occult lung carcinoma. The unusual clinical features of this case are discussed, and the English language literature on zygomycoses in patients with solid tumours is reviewed. Possible predisposing factors are discussed.
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ranking = 0.33333333333333
keywords = zygomycosis
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16/17. iron overload is a risk factor for zygomycosis.

    Well-recognized risk factors for zygomycosis include diabetic ketoacidosis, immunocompromise, and deferoxamine therapy for iron or aluminum overload, usually in patients undergoing kidney dialysis. We report a case of fatal nasal-orbital-cerebral zygomycosis in an 82-year-old man with known myelodysplasia and well-controlled diabetes. He was not receiving deferoxamine. Despite radical surgery and amphotericin b therapy, he died; primary hemochromatosis with gross iron overload was found post mortem. Experimental evidence suggests iron overload without deferoxamine therapy may be a risk factor for zygomycosis; the findings in this case would support this hypothesis.
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ranking = 1.1666666666667
keywords = zygomycosis
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17/17. Fatal rhino-orbital-cerebral zygomycosis.

    Rhinocerebral zygomycosis is usually an aggressive, fulminant and, at times, fatal disease most often affecting poorly controlled diabetics of all ages. We report the case of a 13-month-old white boy, a previously undiagnosed diabetic. He came to our hospital with recurrent epistaxis, decreasing consciousness, and a small visible infection at the inner canthus of the left eye. Initial evaluation revealed that the patient was in diabetic ketoacidosis. Despite aggressive medical and surgical treatment, his condition deteriorated rapidly, including the development of diabetes insipidus, and he died 4 days after admission. At autopsy, he was found to have fungal cerebritis (rhizopus) with multiple areas of infarction and massive cerebral edema.
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ranking = 0.83333333333333
keywords = zygomycosis
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