1/13. Laparoscopic management of Sertoli-Leydig cell tumors of the ovary. A report of two cases.BACKGROUND: sertoli-leydig cell tumor is a rare ovarian tumor with an incidence of < .5% of all ovarian tumors. laparotomy is the standard approach to these cases. CASES: Sertoli-Leydig cell tumors were diagnosed in two young, nulliparous, infertile women. Both presented with secondary amenorrhea. Virilization was found in one. Their testosterone levels were high, and sonography revealed a solid, echogenic mass in the fornix. Laparoscopic removal was performed. Both women achieved normal menstruation one month after the operation, and one became pregnant and gave birth to a healthy infant. CONCLUSION: There are very few case reports of laparoscopic removal of such tumors. Laparoscopic surgery, which is minimally invasive and cosmetically acceptable and has a speedy recovery, should be the approach of choice for these patients.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
2/13. Restoration of menstruation after chemotherapy-induced amenorrhoea in a patient with ovarian immature teratoma.We described a rare case of a 20-year-old woman with an ovarian immature teratoma who resumed regular spontaneous menses after more than 5 years of chemotherapy-induced amenorrhoea. Efforts to reverse chemotherapy-induced ovarian failure can be continued even after persistent menstrual dysfunction of 5 or more years.- - - - - - - - - - ranking = 4keywords = menstruation (Clic here for more details about this article) |
3/13. Compound melanocytic nevus arising in a mature cystic teratoma of the ovary.A 28-year-old woman complained of irregular menstruation. Abdominal ultrasound and magnetic resonance imaging (MRI) examinations revealed a cystic tumor in the left ovary. A histological examination of the resected ovary revealed that the lesion was a mature cystic teratoma. In this tumor, components such as skin with appendages, a thyroid gland, mucosa of the digestive tract and a submandibular gland were observed. Interestingly, compound melanocytic nevus was also present in the skin component. To the best of our knowledge, this is the sixth reported case of nevus arising in a mature cystic teratoma of the ovary. Despite the extreme rarity of such a lesion, pathologists should recognize the possibility of such lesions occurring in ovarian teratoma.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
4/13. Sclerosing stromal tumor of ovary.Sclerosing stromal tumor of the ovary is a rare ovarian disease with prevalence of 1.5% to 6% of ovarian stromal tumors. We present a 24-year-old woman with irregular menstruation for 6 months and a self-palpable lower abdominal mass. Enucleation of the left ovarian tumor was undertaken. Gross examination showed a soft elastic tumor with a smooth outer surface and diffusely white edematous stroma with scattered yellowish nodular areas on the cut surface. Histologic study showed that the cellular nodules consisted of a disorganized admixture of fibroblasts and round vacuolated tumor cells. The cellular nodules were separated by edematous hypocellular fibrous tissue forming a pseudolobular appearance. Regular menstruation resumed after the surgery and no evidence of tumor relapse during 1 year of follow up.- - - - - - - - - - ranking = 2keywords = menstruation (Clic here for more details about this article) |
5/13. Pure XY gonadal dysgenesis presenting as secondary amenorrhea. A case report.Secondary amenorrhea developed after two years of normal menstruation. On investigation, the patient's karyotype was 46,XY, the serum testosterone and free androgen index were elevated, and bilateral gonadoblastomas and dysgerminomas were found in the gonads. The uterus, fallopian tubes and vagina were normal. The gonads were removed and chemotherapy given because of lymphadenopathy.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
6/13. CA-125 concentrations in malignant and nonmalignant disease.CA-125 is a high-molecular-mass glycoprotein expressed on the cell surface of some derivatives of embryonic coelomic epithelium. This tumor-associated antigen widely used to monitor ovarian carcinomas has been suggested as a promising noninvasive test that could differentiate benign from malignant conditions. Based on results of various studies, CA-125 measurement appears to be very useful in monitoring the response to therapy of ovarian carcinoma and for detecting tumor recurrence as exemplified in Case 1. However, because of the high frequency of false-positive results associated with many benign conditions, CA-125 is of little value as a screening test for ovarian carcinoma. A brief list of the most common benign conditions associated with CA-125 increase includes menstruation, pregnancy, benign pelvic tumors, pelvic inflammatory diseases, ovarian hyperstimulation syndrome, peritonitis, and many diseases leading to pleural effusion or ascites. According to several studies, a marked increase in CA-125 of greater than 1000 units/mL, as seen in Case 2, and even up to 5000 units/mL, could be seen in some benign conditions. This finding further limits the value of CA-125 as a potential noninvasive procedure to differentiate benign from malignant diseases. Although values up to 10,000 units/mL are occasionally seen in patients with ovarian carcinoma, we are reluctant to state that any concentration of CA-125 can be clearly diagnostic of malignancy.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
7/13. Ectopic hyperprolactinemia resulting from an ovarian teratoma.Detection of an elevated prolactin level in the nonpregnant patient usually directs attention to the investigation of the pituitary gland. We describe a patient with secondary amenorrhea and galactorrhea in whom such an elevated prolactin level did initially lead to the discovery of a pituitary mass that was treated first unsuccessfully with surgery, and then successfully with medical therapy. After medical therapy normal menstruation continued, galactorrhea recurred intermittently, and the prolactin level rose again and remained in the approximately 36-micrograms/L range. However, 2 years later an ovarian teratoma was discovered incidentally and was removed surgically. On pathological evaluation the teratoma was noted to include prolactin-containing tissue, and immediately after surgery the patient's prolactin level and responsiveness to stimulatory testing returned to normal. To our knowledge this is the first case report of the association of clinically evident hyperprolactinemia with an ovarian cystic teratoma that contained prolactin-producing tissue.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
8/13. castration-sparing management of an adolescent with huge bilateral cystic teratomas of the ovaries.In order to avoid the castrating effect of bilateral oophorectomy in a teenager with bilateral huge ovarian teratomas, a plane of dissection was developed near each ovarian hilum, and the cysts were excised in toto without spillage. Postoperatively, menstruation resumed promptly as the hormonal levels returned to normal. Benign cystic teratomas of the ovaries can be excised without the need for oophorectomy. This ovarian-sparing technique is particularly useful in cases of bilateral teratomas, where reproductive and hormonal functions should be preserved.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
9/13. endometriosis in a patient with Rokitansky-Kuster-Hauser syndrome.This case with Rokitansky-Kuster-Hauser syndrome and right ovarian endometriosis was previously presented as a proof against the transplant theory of Sampson. New operative findings showed a functioning endometrium in a right occult rudimentary horn and retrograde menstruation through the Fallopian tube with hematosalpinx, tubal endometriosis, right ovarian and appendicular endometriosis.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
10/13. Hormonal studies and Doppler flow imaging of ovarian lipoid cell tumors: report of two cases.Ovarian lipoid cell tumors are very rare. We report two cases with abnormal menstruation, hirsutism, clitoromegaly and marked elevations of serum testosterone. Sonography revealed unilateral adnexal solid tumors. Flow velocity wave form study showed apparent flow within the tumor with the resistance index ranging from 0.42 to 0.49 in both cases. Unilateral oophorectomy and contralateral ovarian biopsy were performed. frozen sections showed lipoid cell tumors without malignant change. During surgery, direct ovarian venipuncture showed a discrepancy in testosterone level in the bilateral ovaries of both patients and large ovarian-peripheral venous gradients in case 2. The testosterone concentration returned to normal postoperatively in both cases. Flow velocity wave form study and direct ovarian venipuncture are useful tools for evaluation of androgen-secreting tumors preoperatively and intraoperatively.- - - - - - - - - - ranking = 1keywords = menstruation (Clic here for more details about this article) |
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