Cases reported "Palatal Neoplasms"

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1/37. Primary malignant melanoma of the hard palate.

    A case of malignant melanoma of the oral cavity is presented. The very high frequency of squamous cell carcinoma of the palate in Visakhapatnam, india, is compared to the rarity of malignant melanoma, even though pigmentation of the oral cavity is quite common in this geographical region.
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ranking = 1
keywords = malignant melanoma, melanoma
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2/37. Desmoplastic malignant melanoma of the palatal alveolar mucosa: sustained disease-free survival after surgery and postoperative radiotherapy.

    Aggressive surgical and radiotherapeutic management of a patient with desmoplastic malignant melanoma arising from the mucosa of the oral cavity has resulted in disease-free survival of more than 2(1/2) years after diagnosis. This case represents only the tenth reported instance of desmoplastic malignant melanoma arising from the oral cavity and only the third for which survival has exceeded 2 years. Details of the clinical, histopathologic, and therapeutic features of the case are provided to augment the paucity of literature available to clinicians managing this rare disease.
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ranking = 1
keywords = malignant melanoma, melanoma
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3/37. Amelanotic malignant melanomas of the oral mucosa.

    Oral amelanotic melanomas are rare and the prognosis is poorer than that of pigmented melanomas because of delays in establishing the correct diagnosis and in the initiation of treatment. Amelanotic forms are also thought to be biologically more aggressive than pigmented melanomas. We have seen three cases of oral amelanotic melanomas since 1970, in two of whom the diagnosis was long delayed. Two lesions were not pigmented but one had slight pigmentation. One patient simultaneously had both an amelanotic and a pigmented melanoma in the oral cavity. lymph node metastases and distant metastases developed in all patients, two of whom eventually died of the disease. early diagnosis by histological examination together with immunostaining with S100 and HMB-45 are the keys to improve survival for patients with amelanotic melanoma.
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ranking = 1.1206485917041
keywords = malignant melanoma, melanoma
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4/37. Nontraumatic massive hemoperitoneum from melanoma metastatic to the uterus.

    We have reported a case of nontraumatic massive hemoperitoneum caused by melanoma metastatic to the uterus that was readily managed with surgery. We believe this strategy provided effective palliation, improved quality of life and potentially prolonged survival for this patient.
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ranking = 0.37831827086455
keywords = melanoma
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5/37. Intraoral melanoma: long-term follow-up and implication for dental clinicians. A case report and literature review.

    Primary intraoral melanoma is a rare neoplasm with a poor prognosis, accounting for 1% to 8% of all melanoma in europe and the united states. The incidence (12%) and 5-year survival rate (17.4%) are higher in japan. We report a case of oral lentiginous melanoma in a Japanese-American man who survived disease-free for more than 5 years after surgery, radiation therapy, and chemotherapy but developed chronic mucositis of the palate under the denture in the primary radiated field. This lesion responded to antifungal therapy. Subsequent multiple biopsies ruled out the recurrence of melanoma but demonstrated prolonged melanocytic hyperplasia and focal epithelial atypia. We reviewed clinical differences in oral melanoma reported in the united states and Japanese literature, and describe the wide variety of oral clinical features of postoperative radiation and chemotherapy, as well as the oral tissue changes caused by denture-induced mucositis and candidiasis in such patients. Dental clinicians should conduct a thorough head, neck, and oral follow-up with increased vigilance in patients with a history of prior cancer.
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ranking = 0.68097288755618
keywords = melanoma
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6/37. Multiple focal pigmented lesions in the maxillary tuberosity and hard palate: a unique display of intraoral junctional nevi.

    The pigmented conditions located in the oral cavity have a diverse genesis ranging from vascular lesions to exogenous and endogenous pigmentations. In this report we have documented the unusual occurrence of multiple intraoral junctional nevi in a patient. A review of the patient's past dental records revealed that 2 of these lesions were first noticed 8 years earlier; however, no efforts were made to identify the nature of the pigmentations. Removal of 4 lesions and subsequent histopathological analysis revealed the presence of junctional nevi. This case illustrates the importance of a thorough clinical and histological work-up when dealing with pigmented lesions in the oral cavity. The excision of all suspected oral nevi is warranted because they cannot be clinically differentiated from other pigmented lesions, including oral melanoma. In addition, the potential of junctional nevi to undergo malignant transformation in the oral cavity is undetermined.
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ranking = 0.075663654172909
keywords = melanoma
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7/37. Oral mucosal melanoma: a series of case reports.

    INTRODUCTION: Due to the rarity of oral malignant melanomas case reports are a necessary source of information. Ten new cases are reported with a minimum follow-up of 3 years. patients AND methods: patients were treated during a period of 10 years. Clinical, demographic and pathologic findings were examined. RESULTS: In 6 males (60%) and 4 females with a mean age of 64.3 years the tumour locations were: hard palate-maxillary gingiva (3 cases), maxillary gingiva (2), lower gingiva (2), tongue (2), hard/soft palate-buccal mucosa (1). Pre-existing melanotic pigmentation had been present in 4 patients. Four patients were in stage I, 5 in stage II, and 1 in stage III. Surgical excision was the primary treatment in 9 cases. Five patients underwent simultaneous neck dissections. All patients received radiation and multimode adjuvant therapies. After a 3-year follow-up 3 patients are still alive (50% (2/4) of those presenting in stage I and 20% (1/5) in stage II). CONCLUSIONS: Due to the rarity of oral melanoma, individual experience is limited. The poor prognosis and the different treatments reflect this situation.
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ranking = 0.54498493753121
keywords = malignant melanoma, melanoma
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8/37. A case of double cancer involving oral malignant melanoma and gastrointestinal stromal tumor (GIST).

    We report a very rare case of double cancer involving palatal malignant melanoma and gastrointestinal stromal tumor (GIST), a rare tumor of the gastrointestinal tract originating from a primitive mesenchymal cell. After chemotherapy, radiation therapy, and treatment with interferon and OK-432, the GIST was resected and the melanoma disappeared. The patient has had no evidence of recurrent tumor, and the patient's clinical course has been uneventful for 1 year. This is probably the first report of synchronous double cancer involving oral malignant melanoma and GIST.
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ranking = 1.0756636541729
keywords = malignant melanoma, melanoma
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9/37. Malignant melanoma of the oral cavity--case reports and review of literature.

    melanoma is a malignant tumor of melanocytes or their precursor cells. It is the third most common skin cancer and is one of the most biologically unpredictable neoplasms. sunlight is an important etiological factor in cutaneous melanoma. Oral melanoma is relatively uncommon, exhibiting a definite predilection for palate and maxillary gingiva, and is twice as common in males as in females. We herewith report three cases of oral melanoma out of which two occurred on the palate and one in the maxillary gingiva. Their clinical presentations, histopathology and management are discussed.
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ranking = 0.52964557921037
keywords = melanoma
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10/37. A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate.

    This paper describes the first documented case of mucoepidermoid carcinoma (MEC) with melanin pigmentation manifested in the palate. Histopathological sections showed a neoplasm composed of epidermoid, mucous-producing and intermediate cells. Numerous large cells contained dark pigmented materials. Fontana Masson staining revealed dendritic melanocytes and melanin granules. HMB-45, Melan A and S-100 protein were all positive for melanocytes. Histopathological examination was not typical for malignant melanoma; the lesion was diagnosed as a low-grade MEC with melanin pigmentation.
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ranking = 0.16666666666667
keywords = malignant melanoma, melanoma
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