Cases reported "Parakeratosis"

Filter by keywords:



Filtering documents. Please wait...

1/11. psoriasis associated with human immunodeficiency virus in an infant.

    psoriasis is commonly reported in association with hiv in adults. A 3-month-old girl with hiv presented with a widespread eruption and was diagnosed with psoriasis. This is the first infant reported with psoriasis in association with hiv infection. The relationship between the two entities is discussed, as is the role of treatment with zidovudine.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)

2/11. Granular parakeratosis: four paediatric cases.

    Axillary granular parakeratosis (GP) was first described in 1991 as a peculiar eruption presenting with erythematous hyperpigmented and hyperkeratotic papules and plaques of the cutaneous folds frequently associated with pruritus. Histopathology shows a characteristic picture with a conspicuous granular appearance of the parakeratotic horny layer. Until now, only 24 adults, mainly women aged over 40 years, have been reported with GP. We demonstrate that this condition can also occur in young children. Four children aged between 10 and 24 months had asymptomatic hyperpigmented scaling papules 2-3 mm in diameter located on the groin, lower back, buttocks and flanks. In all cases the mothers reported the habit of frequent washing followed by application of many topical products. biopsy revealed the same features in all four patients: the epidermis showed a thickened horny layer with a unique compact parakeratosis with maintenance of the stratum granulosum and marked retention of keratohyaline granules throughout the stratum corneum.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)

3/11. Granular parakeratosis in children: case report and review of the literature.

    Granular parakeratosis is a cutaneous eruption with erythematous and/or brownish hyperkeratotic papules and plaques which are exclusively localized to intertriginous areas and show histopathologic features of an unusual form of parakeratosis. The etiology is unknown, but the excessive use of various topical preparations (e.g., ointments and deodorants) has been associated with this disease. It has heretofore been reported only in adults. We report two children, ages 3 and 5 months, with characteristic lesions in the groin associated with topical pomades used to prevent diaper rash. This is the first report associating the clinical presentation and the histopathologic diagnosis of granular parakeratosis in children. The literature on this entity is also reviewed and all case reports are summarized.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)

4/11. Dermatophyte-related granular parakeratosis.

    A patient presented with a two-month history of an annular eruption on her back. Biopsies of this process revealed dermatophytosis and concurrent granular parakeratosis. This patient's eruption resolved completely with antifungal therapy suggesting that the fungal organisms caused the granular parakeratosis.
- - - - - - - - - -
ranking = 2
keywords = eruption
(Clic here for more details about this article)

5/11. Axillary granular parakeratosis.

    BACKGROUND: Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum. OBJECTIVE: The aim of the article is to review the clinical manifestations and treatment of granular parakeratosis. methods: A case report and literature review are presented. RESULTS: Twenty-six cases of granular parakeratosis now have been reported and reviewed. CONCLUSION: Granular parakeratosis occurs predominantly in middle age women and most frequently in the axilla. A number of treatments have been applied to the 26 cases reported to date, without consistent responses. No evidence-based therapy can be suggested at present.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)

6/11. Axillary granular parakeratosis.

    A 71-year-old man developed a pruritic axillary eruption. Histopathologic examination showed laminated orthokeratosis, parakeratosis, and hypergranulosis. There changes were consistent with a diagnosis of axillary granular parakeratosis. Axillary granular parakeratosis is an intertriginous eruption that is usually found in the axillae of middle-aged women and is characterized clinically by pruritic, erythematous, hyperkeratotic plaques and histologically by parakeratosis with retention of keratohyaline granules. Pathophysiology is thought to involve a defective profilaggrin-filaggrin pathway. Evidence-based treatment of this disorder is not available.
- - - - - - - - - -
ranking = 2
keywords = eruption
(Clic here for more details about this article)

7/11. Axillary granular parakeratosis.

    The term axillary granular parakeratosis is proposed for a unique axillary eruption with distinct histopathologic features. Four middle-aged to elderly patients (three women, one man) had unilateral or bilateral, usually pruritic, hyperpigmented to bright red patches in the axillae. biopsy specimens revealed severe compact parakeratosis with the stratum corneum measuring 80 to 250 microns in maximal thickness, maintenance of the stratum granulosum, remarkable retention of keratohyaline granules throughout the stratum corneum, and vascular proliferation and ectasia. A contact reaction to an antiperspirant/deodorant is suspected as the cause. We speculate that the offending agent alters the maturation sequence of the stratum granulosum and stratum corneum, possibly by interfering with the degradation of filaggrin precursor to filaggrin units.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)

8/11. Porokeratotic eccrine ostial and dermal duct nevus.

    A 6-year-old girl with congenital porokeratotic eccrine ostial and dermal duct nevus involving the palmoplantar surfaces (ie, the back of the hands and feet), the limbs, the neck, and the axillae is described. The clinical and histopathologic findings are presented. This entity should be taken into consideration in the differential diagnosis of linear keratotic cutaneous eruptions.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)

9/11. Neonatal citrullinemia associated with cutaneous manifestations and arginine deficiency.

    A patient with neonatal citrullinemia (argininosuccinic acid synthetase deficiency), a heritable disorder of the urea cycle, developed a generalized cutaneous eruption at 35 days of age. The skin lesions consisted of erosive, erythematous, scaling patches and plaques. The plasma arginine concentration at that time was low. After treatment with oral arginine supplements, the cutaneous lesions rapidly resolved and the plasma arginine concentration normalized. Histologic features of pretreated lesions included parakeratosis, crust formation, absence of a granular cell layer, pallor of the upper epidermal cells, and a mild, superficial, perivascular, mononuclear-cell infiltrate. Since the patient's skin lesions responded to arginine supplements, and since arginine is a component of keratin, we postulate that the skin lesions are the result of arginine deficiency.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)

10/11. Heck's disease (focal epithelial hyperplasia).

    A patient and his mother noted the insidious appearance of a distinctive benign papular eruption confined to the mucosa of the lips. The clinical pattern and histologic findings fulfill the criteria of a recently described entity, focal epithelial hyperplasia. An electron microscopic search for viral particles was negative. Arguments for both a viral and a hereditary pathogenesis have been put forth, but the etiology of the condition remains controversial. This disorder may be more frequently reported as dermatologists become increasingly aware of its existence.
- - - - - - - - - -
ranking = 1
keywords = eruption
(Clic here for more details about this article)
| Next ->


Leave a message about 'Parakeratosis'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.