Cases reported "Pelvic Neoplasms"

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1/6. Growing teratoma syndrome vs chemotherapeutic retroconversion: case report and review of the literature.

    BACKGROUND: Immature ovarian teratoma is the third most common germ cell tumor (GCT) following dysgerminoma and endodermal sinus tumor. The treatment of choice during childbearing age for immature teratoma composes of unilateral oophorectomy and in case of metastatic disease postoperative chemotherapy (BEP). Finding a solid mass in the peritoneal or chest cavity during routine follow up raises the suspicion of distance recurrence. DiSaia was the first to describe the appearance of benign distant metastasis during routine follow up. He termed this phenomenon "chemotherapeutic retroconversion". Latter, Logothetis described what seems to be a similar phenomenon in testicular non-seminomatous germ cell tumor (NSGCT) that he called the "growing teratoma syndrome". CASE: We present a case of a 12-year-old girl treated for growing teratoma syndrome after primary ovarian GCT. CONCLUSION: review of the literature shows that this syndrome and the "chemotherapeutic retroconversion" are probably the same phenomenon.
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ranking = 1
keywords = dysgerminoma
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2/6. Ovarian dysgerminoma metastatic to the breast.

    A 16-year-old girl underwent a right salpingo-oophorectomy for a pure dysgerminoma limited to the right ovary. One month later, she developed a right pelvic mass along with abdominal lymphadenopathies, peritoneal carcinomatosis, left breast mass, and left axillary node. Cytology of the breast mass was suggestive of a pure dysgerminoma. breast metastases of epithelial ovarian carcinoma are uncommon. In the literature, this is the first case of a breast metastasis of an ovarian dysgerminoma.
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ranking = 7
keywords = dysgerminoma
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3/6. Ovarian dysgerminoma with embryonal carcinoma: A case report.

    The association of an ovarian dysgerminoma with embryonal carcinoma in a 19-year-old woman is described. This is a highly malignant combination resulting in very rapid tumour growth and dissemination. A case report is presented and the aetiology, malignant potential and subsequent management of this most unusual tumour are discussed.
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ranking = 5
keywords = dysgerminoma
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4/6. Case report of dysgerminoma in a patient with 46,XX pure gonadal dysgenesis.

    A clinicopathological study of a 42-year-old female with pure gonadal dysgenesis and dysgerminoma was made. At the age of 29, the patient with primary amenorrhea had been evaluated clinically and cytogenetically. (1) The results of cytogenetic studies were X-chromatin positive and revealed a karyotype in peripheral blood leukocytes of 46,XX. (2) Laboratory studies indicated hypergonadotropic hypogonadism and no response of the gonads to the human menopausal gonadotropin stimulation test. (3) At laparotomy, the gonads were streak-like. Pathological examinations of biopsy specimens from both gonads revealed dense, fibrous connective tissue resembling ovarian stroma and no primary follicles. Eleven years after the laparotomy, the patient complained of lower abdominal distention and severe pain, and laparotomy then revealed a 15 X 17-cm right solid adnexal mass occupying the pelvic cavity. The histological diagnosis of tissues from the partially removed tumor was pure dysgerminoma. Second-look operation after Linac X-ray irradiation showed complete remission of the residual tumor. Insofar as we are aware, the present patient represents the first case of dysgerminoma which occurred in the dysgenetic gonads of a phenotypic female with normal 46,XX sex-chromosomal constitutions in peripheral blood leukocytes and the skin fibroblasts although a possibility exists that mosaicism was possibly present but undetected, particularly since the streak gonads were not analyzed chromosomally.
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ranking = 7
keywords = dysgerminoma
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5/6. Germ cell tumors in monozygous twins with gonadal dysgenesis and 46,XY karyotype.

    Monozygous twin phenotypic females, aged 18, with primary amenorrhea and a 46,XY karyotype and bearing germ cell tumors are described. Patient 1 had a large pelvic tumor involving the uterus, oviduct, and intestine. histology revealed the choriocarcinoma pattern. No ovarian or testicular tissue was identified. The preoperative serologic pregnancy test was positive. After surgery the urinary human chorionic gonadotropin value was 2500 units per 24 hours. The patient died 2 months after the operation despite chemotherapy. Patient 2 was admitted to the hospital for evaluation following the discovery of pelvic tumor in her twin sister. She had 1 streak gonad harboring gonadoblastoma and, on the opposite side, a gonadoblastoma overgrown by dysgerminoma. The patient is well 4 years after surgery. The risk of malignancy in individuals with XY gonadal dysgenesis is emphasized, and examination and confirmation of karyotype of siblings are recommended.
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ranking = 1
keywords = dysgerminoma
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6/6. dysgerminoma in mother and daughter: use of lactate dehydrogenase as a tumor marker in the child.

    A 7-year-old girl presented with an extragonadal dysgerminoma arising from the pelvis. Her mother had been treated for a histologically identical pituitary tumor 3 years previously. The child's serum lactate dehydrogenase (LDH) level was markedly elevated at presentation and fell as the tumor responded to treatment. The potential use of LDH as a marker for gonadal dysgerminoma is well documented, but raised LDH in association with primary extragonadal dysgerminoma has not been described previously. In addition, this is the first report of extragonadal dysgerminoma occurring in female relatives.
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ranking = 4
keywords = dysgerminoma
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