Cases reported "Peritoneal Neoplasms"

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1/18. Multiple nodular metastases in mesenteric panniculitis by uterine papillary serous adenocarcinoma (UPSC): CT appearance of a case.

    Intra-abdominal panniculitis is a thickening of the mesentery of the small/large intestine due to infiltration of lipid-laden macrophages associated with a variable amount of fibrosis. This condition is rarely associated with malignant neoplasms. We report the computed tomography (CT) findings of a patient treated for uterine papillary serous adenocarcinoma (UPSC). She had mesenteric panniculitis where metastatic tumor nodules implanted. This was the only intraperitoneal recurrence. To our knowledge, no such finding has been reported in the gynecologic and radiologic literature to date. On CT images, the differential diagnosis is with cystic dilatations of mesenteric lymph vessels.
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keywords = gynecologic
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2/18. Ovarian carcinoid: management of primary and recurrent tumors.

    We present a case of Stage I ovarian carcinoid tumor recurrent in the peritoneal cavity and review the pertinent literature concerning the management of this disease. Based on the data in the gynecologic and general surgery literature, it appears that primary complete cytoreductive surgery usually affords a high cure rate. Reexploration and attempt at complete resection of this slow-growing tumor appears to provide significant and prolonged palliation and is indicated for recurrent disease.
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keywords = gynecologic
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3/18. Intra-abdominal desmoplastic small round cell tumor in a 68-year-old female.

    BACKGROUND: desmoplastic small round cell tumor (DSRCT) of the peritoneum typically occurs in young adults. The mean age of females with DSRCT is 20 years. We describe a DSRCT with an unusual age of presentation mimicking a metastatic ovarian neoplasm. CASE: A 68-year-old para 4 female presented with abdominal enlargement. Laparatomy showed multiple tumor nodules attached to the peritoneal surface. The tumor was debulked. The histological findings were characteristic for DSRCT. Adjuvantly the patient received cytotoxic chemotherapy but died of recurrent disease 3 months after initial diagnosis. CONCLUSION: DSRCT should be added to the differential diagnosis of unusual gynecologic malignancies in elderly as well as younger females. Identification of DSRCT is important because it can be confused with primary ovarian neoplasms.
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keywords = gynecologic
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4/18. Malignant peritoneal mesothelioma treated by continuous hyperthermic peritoneal perfusion chemotherapy.

    Malignant mesothelioma of the peritoneum is a rare tumour for which the therapeutic approach has not yet been standardized. The efficacy of the current regimes is limited. Effective locoregional therapy is crucial, since this tumour is most often confined to the peritoneal cavity at the time of the initial diagnosis and remains there for much of its clinical course. If and when haematogenous metastases occur, they rarely contribute to the death of the patient, which is often caused by the overgrowth of the primary tumour and its local complications. A case of diffuse malignant peritoneal mesothelioma treated by cytoreductive surgery and continuous hyperthermic peritoneal perfusion with cisplatin is reported. The patient received systemic combination chemotherapy postoperatively. She is in good condition and free of disease 28 months after her treatment. Continuous hyperthermic peritoneal perfusion chemotherapy has recently been used in patients with secondary peritoneal carcinomatosis from digestive and gynecological malignancies with promising results. It is also possible that the same treatment alone or in combination with systemic chemotherapy may be effective in the treatment of primary peritoneal malignancies, as in the case of diffuse peritoneal mesothelioma.
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keywords = gynecologic
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5/18. BRCA1-related malignancies in a family presenting with von Recklinghausen's disease.

    BACKGROUND: The association between neurofibromatosis and gynecologic malignancies is rarely reported in the literature. Both BRCA1 and NF1 genes are located on the long arm of chromosome 17. CASE: We have observed a pedigree showing several individuals affected by both type 1 neurofibromatosis (NF1) and breast or coelomatic cancers. The number of individuals affected, their degree of relationship, and the early age at onset were suggestive of an hereditary breast/ovarian cancer syndrome. Linkage analysis was performed in order to establish whether markers in the chromosome 17 region containing the BRCA1 and NF1 loci were shared by affected individuals. Screening for BRCA1 mutations was performed by PTT and SSCP. Analysis of chromosome 17 dna markers in the five family members tested show that three individuals affected by both NF1 and carcinomas share a common haplotype including the NF1 and BRCA1 loci on chromosome 17. mutation analysis showed the presence of a nonsense mutation within BRCA1 exon 12 in two individuals, mother and daughter, affected by breast and peritoneal cancer, respectively, as well as in the son, who had rectal cancer at the early age of 27 years. All three subjects also had NF1. CONCLUSION: The concurrence of NF1 and hereditary breast/ovarian cancer in this family is likely due to the presence of two linked mutations at the NF1 and BRCA1 loci.
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keywords = gynecologic
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6/18. trisomy 21 as the only recurrent chromosomal anomaly in a clinically aggressive ovarian carcinoma.

    A case of a highly aggressive grade III poorly differentiated serous adenocarcinoma of the ovary was determined to exhibit trisomy 21 as the sole chromosomal abnormality. To eliminate the possibility that this trisomy was constitutional, the patient's blood cells were subjected to locus specific 21q22.13 approximately q22.2 chromosome probe using fluorescence in situ hybridization (FISH). Concurrently, using FISH and the same probe the tumor tissue was also tested. We discovered that 48% of the cells of the tumor tissue either had trisomy or tetrasomy of chromosome 21. Two normal signal patterns for chromosome 21 in blood and absence of Down morphology in the patient confirmed the presence of trisomy to be limited to the tumor tissue. To the best of our knowledge, this is the only case where trisomy 21 was shown to be the sole chromosomal anomaly in a serous carcinoma of the ovary. Tumorigenesis in gynecologic malignancies is discussed in the light of oncogenes present on chromosome 21.
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keywords = gynecologic
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7/18. Spontaneous internal jugular vein thrombosis associated with leiomyosarcoma of the omentum.

    A case of spontaneous internal jugular vein thrombosis associated with distant malignancy is presented. This unusual manifestation of a hypercoagulable state was associated with a low-grade epithelioid leiomyosarcoma of the omentum. It was discovered on a gynecologic oncology service in a patient explored for a pelvic abdominal mass.
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keywords = gynecologic
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8/18. Cystic teratoma in a supernumerary ovary of the greater omentum. A case report.

    Supernumerary ovary is a rarely described gynecologic finding. A 47-year-old woman presented with abdominal pain and a palpable lower abdominal mass. The mass, removed in a partial omentectomy, was found to consist of a supernumerary ovary with a cystic teratoma.
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keywords = gynecologic
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9/18. Unexpected metastatic lobular carcinoma of the breast with intraabdominal spread and subsequent port-site metastasis after diagnostic laparoscopy for exclusion of ovarian cancer.

    INTRODUCTION: Although lobular carcinomas metastasize primarily to lymph nodes, bone, lung and liver, they can also spread to the gastrointestinal tract, peritoneum and gynecologic organs. CASE REPORT: We report a case of intraperitoneal carcinomatosis of a lobular breast carcinoma that metastasized primarily to the peritoneum, with a subsequent abdominal wall invasion at the trocar site following laparoscopic surgery for the exclusion of an ovarian carcinoma. DISCUSSION: Port-site metastases (PSM) have occurred after laparoscopic surgery for endometrial, fallopian tube, ovarian, and cervical cancers. This is the first report of PSM of a lobular breast carcinoma primarily metastasized to the abdominal cavity. Every surgeon should be aware of the metastatic pattern of breast cancer, especially in relation to its histological subtypes. This case report emphasizes that PSM can occur in various kinds of gynecologic tumors, including breast cancer.
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ranking = 2
keywords = gynecologic
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10/18. Malignant mixed mullerian tumor of primary mesenteric origin.

    Malignant mixed mullerian tumor (MMMT) is a rare tumor. A literature search revealed very few reports on MMMT, especially those arising in the peritoneum. We recently encountered an MMMT of primary mesenteric origin associated with left fallopian tube cancer. There have been no previous reports about its occurrence in the mesentery. When cases of peritoneal MMMT were reviewed, the disease was found to be associated with synchronous or metachronous gynecologic tumors of mullerian duct origin (ie, ovarian tumors, primary serous carcinoma of the peritoneum, fallopian tube cancer, endometrial cancer, and adenocarcinoma of the cervix) in 12 out of 32 patients (37.5%). Peritoneal MMMT are frequently associated with gynecologic tumors.
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ranking = 2
keywords = gynecologic
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