11/14. Metastatic placental lymphoma associated with maternal human immunodeficiency virus infection.BACKGROUND: pregnancy complicated by maternal human immunodeficiency virus (hiv) infection is increasing in frequency. This report describes a maternal malignancy associated with hiv infection that may complicate pregnancy. CASE: A 33-year-old primigravida was delivered by cesarean. Histologic examination of the placenta revealed the presence of metastatic non-Hodgkin lymphoma of B-cell origin. The patient was then found to be infected with hiv. Nine months postpartum, she was diagnosed with immunoblastic lymphoma. She is currently undergoing chemotherapy. CONCLUSION: Non-Hodgkin lymphoma of B-cell origin is an indication of AIDS. Pregnancies associated with maternal hiv infection may be complicated by this malignancy, which may metastasize to the products of conception. Careful examination of the placenta can detect metastases in women with non-Hodgkin B-cell lymphoma.- - - - - - - - - - ranking = 1keywords = conception (Clic here for more details about this article) |
12/14. pregnancy complicated by medulloblastoma with metastases to the placenta.BACKGROUND: Maternal malignancy may complicate as many as one in 1000 pregnancies. Rarely, the tumor may metastasize to the products of conception. We here describe a case of medulloblastoma metastatic to the placenta. CASE: A 21-year-old woman who had previously undergone resection of a posterior fossa medulloblastoma was admitted at 20 weeks' gestation complaining of low back pain. Investigation revealed medulloblastoma metastatic to the bone marrow. The pregnancy was prolonged to 29 weeks' gestation, at which time she was delivered by cesarean. The postoperative course was complicated by coagulopathy, massive bleeding, and pneumonia leading to death. autopsy showed medulloblastoma metastatic to the bone marrow and placenta. CONCLUSION: Primary intracranial neoplasms may metastasize to the products of conception. The dramatic course of the disease in this patient may suggest that medulloblastoma is responsive to hormonal therapy.- - - - - - - - - - ranking = 2keywords = conception (Clic here for more details about this article) |
13/14. Malignant melanoma metastases in the placenta: a case report.Although the coincidence of pregnancy and maternal malignancy is not rare, only 29 cases of metastases to the products of conception have been previously reported and of these, 14 have been of malignant melanoma. The present case of widespread maternal malignant melanoma metastasizing to the placenta further emphasizes this trend. The mother died of malanomatosis two weeks after induced labour at 36 weeks gestation. The infant, despite widespread placental involvement including apparent foetal vascular invasion, is well and without clinical evidence of disease five months after delivery.- - - - - - - - - - ranking = 1keywords = conception (Clic here for more details about this article) |
14/14. Malignancy metastatic to the products of conception: a case report with literature review.breast cancer is rare in adolescent females. breast cancer metastatic to the products of conception is equally uncommon. We describe a 15-year-old girl who at 30 weeks of gestation was diagnosed with metastatic adenocarcinoma of probable breast origin. The placenta showed extensive intervillous disease. Metastatic disease within the intervillous space indicates hematogenous dissemination of cancer and a poor prognosis for the mother. The infant is almost always free of maternal disease unless there is villous invasion. Hormonal changes or immunotolerance by the mother may be involved in the pathogenesis. All placentas in which maternal malignancy is known or suspected should be examined grossly and microscopically.- - - - - - - - - - ranking = 5keywords = conception (Clic here for more details about this article) |
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