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1/2. Potentiation of uremic bleeding by hereditary storage pool disease.

    This study demonstrates that specific bleeding tests can separate the thrombocytopathy of uremia alone from the bleeding disorders caused by uremia superimposed on preexisting platelet dysfunction. The case history of a uremic patient with exaggerated bleeding tendencies is presented. The findings in this patient are compared with the clinical characteristics and platelet function studies of nine other patients with chronic renal failure. The index and other uremic patients were similar except for the clinical bleeding and results of platelet function studies. The patient's nonocclusive bleeding time and measured blood loss during bleeding time tests were increased compared with the other uremic controls. In addition, her platelet aggregation in response to collagen was lower than that of the other uremic subjects. Repeat studies following renal transplantation were consistent with hereditary storage pool disease. An underlying platelet disorder may potentiate the hemostatic defects of uremia. The diagnosis should be suspected in patients with frequent and severe bleeding manifestations. Renal transplantation led to control of clinical bleeding.
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keywords = blood loss
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2/2. Spontaneous subarachnoid haemorrhage occurring in association with a platelet function disorder.

    A case of spontaneous subarachnoid haemorrhage occurring in association with a disorder of platelet function is described and the features of the disorder of platelet function were consistent with a storage pool deficiency. There has been no previous report of subarachnoid haemorrhage with platelet dysfunction.
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keywords = haemorrhage
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