Cases reported "Precancerous Conditions"

Filter by keywords:



Filtering documents. Please wait...

11/48. A case of intraductal papillary adenocarcinoma of the pancreas associated with mass forming chronic pancreatitis.

    A case of intraductal papillary adenocarcinoma of the pancreas associated with mass forming chronic pancreatitis without calcifications is described. Pancreatolithiasis, or calcified pancreas, is recognized as a high risk factor for pancreatic cancer. However, epidemiologic studies have found that carcinoma of the pancreas associated with chronic pancreatitis was rare. The question is whether chronic pancreatitis without calcifications is actually a precancerous background lesion or not. This case suggests that hyperplasia of the pancreatic ductal epithelium may be a precancerous lesion for pancreatic cancer in some patients with chronic pancreatitis.
- - - - - - - - - -
ranking = 1
keywords = precancerous
(Clic here for more details about this article)

12/48. Synchronous anal and penile cancers.

    Malignancies of the anogenital region have similar etiology, including viral infections, sexual habits, social and educational factors. condylomata acuminata represent precancerous lesions. In the available literature, we found no cases of synchronous cancers of anus and penis reported. We report a case of synchronous cancer of the penile foreskin and cancer of the anus in a 36 year-old man. The microscopic diagnosis of the anal lesion was squamous cell cancer, basaloid type. The penile lesion was squamous cell cancer, keratinizing type. Both cancers presented with the in situ component. Immunohistochemical staining (MIB-1) and histological features (koilocytosis, acanthosis and dyskeratosis) indirectly confirmed the past viral infection. Numerous etiological similarities in anogenital cancers entail careful clinical inspection in patients with a malignant lesion in this region and suggest searching for possible other concomitant cancers or precancerous lesions.
- - - - - - - - - -
ranking = 1
keywords = precancerous
(Clic here for more details about this article)

13/48. High-grade pancreatic intraepithelial neoplasia in a patient with familial adenomatous polyposis.

    Familial adenomatous polyposis (FAP) is caused by mutation of the adenomatous polyposis coli (APC) gene and is characterized by multiple colorectal adenomas and tumors of other organs and sites. A 58-year-old woman with FAP syndrome and previous total colectomy presented for routine follow-up examination. Abdominal ultrasound and subsequent endoscopic evaluation revealed ampullary and duodenal polyps, as well as inhomogeneity of the pancreatic head. A pancreaticoduodenectomy confirmed multiple duodenal adenomas. In addition, high-grade pancreatic intraepithelial neoplasia (PanIN-3) was found in the smaller pancreatic ducts. Pancreatic precancerous lesions have only rarely been described in FAP, including 2 pancreatic duct adenomas and 2 intraductal papillary mucinous neoplasms. A review of the world English literature revealed no reports of PanIN-3 in association with FAP. Further studies are required to determine if patients with FAP are at increased risk for pancreatic premalignant lesions.
- - - - - - - - - -
ranking = 0.5
keywords = precancerous
(Clic here for more details about this article)

14/48. A case report of hepatocellular carcinoma within adenomatous hyperplasia: is adenomatous hyperplasia a precancerous lesion or not?

    It is controversial whether adenomatous hyperplasia (AH) of the liver progresses to hepatocellular carcinoma. We experienced two hepatic lesions in a patient (73-yr-old male) with cirrhotic liver. One was diagnosed as HCC and the other was AH including a small HCC histologically. To investigate cell kinetics and the ploidy pattern of these lesions, Feulgen dna-cytofluorometry analysis was performed. The result of this analysis suggested that AH developed into extremely well-differentiated HCC composed of mononuclear diploid cells at first and then was further transformed into clear cell type HCC composed of mononuclear tetraploid cells. The development of human HCC, at least in cirrhotic liver, may therefore be a multi-step process.
- - - - - - - - - -
ranking = 2
keywords = precancerous
(Clic here for more details about this article)

15/48. Selective necrosis of encapsulated malignant lesion within atypical adenomatous hyperplasia of the liver following transarterial embolization. A report of two autopsy cases.

    We report here the morphology of two nodules of atypical adenomatous hyperplasia (AH), a preneoplastic or early developmental stage of hepatocellular carcinoma (HCC), with a fibrously encapsulated malignant lesion occurring in two cirrhotic livers. The two patients had been treated for HCC by transarterial embolization. At autopsy, HCC nodules and several AH nodules were found in each case. Microscopically, two of the several AH nodules contained malignant lesions that showed selective coagulative necrosis: the hepatocytes of the nonmalignant parts of the two AH nodules were viable. The malignant lesions within the atypical AH nodules were surrounded with a fibrous capsule, and the majority of HCC nodules were necrotic; AH nodules themselves, except for malignant lesions, were viable. This suggests to us that there are differences in blood supply between the malignant lesions and surrounding tissue of atypical AH: malignant lesions within atypical AH may be supplied mainly by arterial blood, whereas nonmalignant areas of atypical AH may be dually supplied by both arterial and portal blood. Alternatively, it may be that the malignant lesions in atypical AH are more susceptible to hypoxia caused by transarterial embolization.
- - - - - - - - - -
ranking = 0.55489141998804
keywords = preneoplastic
(Clic here for more details about this article)

16/48. Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnership.

    Cancer prevention in inflammatory bowel disease depends on the detection of precancerous dysplasia during scheduled screening and surveillance colonoscopy, but the detection and diagnosis of dysplasia remain challenging. In this article, we review the risks of cancer and dysplasia in ulcerative colitis and the current prevention recommendations, and through a sample case, we demonstrate an approach that involves an active partnership between the gastroenterologist or surgeon and pathologist. We address the challenge of management of polypoid lesions and incorporate new information about degree of inflammation as an additional risk of neoplasia in these patients.
- - - - - - - - - -
ranking = 0.5
keywords = precancerous
(Clic here for more details about this article)

17/48. breast cancer: early diagnosis of precursor lesions and clinically inapparent carcinoma by fine needle aspiration.

    breast cancer death rate has remained stable at 26 per 100,000 for over 50 years. This control failure is due in large part to difficulty in early diagnosis. Combined clinical evaluation, mammography and fine needle aspiration (FNA) offer the best opportunity for early diagnosis. Non-directed FNA is a useful adjunctive technique and three illustrative cases are presented. Cancer evolves from proliferative epithelial disease of ducts and lobules. Atypical duct hyperplasia in association with family history is a pertinent marker for development of cancer. Identification of hyperplastic lesions traditionally occurs after surgical biopsy and histopathologic review. FNA demonstrates patterns of both duct hyperplasia and atypical duct hyperplasia. Ploidy studies of such smears offer the possibility of selecting precancerous lesions for extirpation. A combination of directed and undirected punctures and ploidy studies may yield early diagnosis of precancerous lesions.
- - - - - - - - - -
ranking = 1
keywords = precancerous
(Clic here for more details about this article)

18/48. Mucinous ductal ectasia of the pancreas: a premalignant disease and a cause of obstructive pancreatitis.

    Five cases of localized ectasiae of pancreatic ducts associated with epithelial mucinous metaplasia have been previously reported by Itai et al. (radiology 1986; 161:697-700). During a 1-year period, we collected four new observations of patients presenting with recurrent attacks of pancreatic pain due to similar clusters of cystlike dilated ducts communicating with the main pancreatic duct and lined by a columnar epithelium interspersed with numerous goblet cells. Duct lumina were filled with mucous. carcinoembryonic antigen levels were high in the pure pancreatic juice, but normal in the blood. Sonography and CT scan showed cystlike, intrapancreatic defects localized three times in the head of the pancreas and once in the body. Endoscopic retrograde cholangiopancreatography (ERCP) showed a huge dilation of some collateral ducts filled by radiolucent defects. The main pancreatic duct was dilated proximally to pathological ducts in three cases. Neither pancreatic stones nor exocrine insufficiency could be demonstrated 7 years after the clinical onset; one case presented with an in situ carcinoma. Since mucinous ductal ectasia is a precancerous state, surgery is mandatory. ERCP is probably the best method of diagnosis.
- - - - - - - - - -
ranking = 0.5
keywords = precancerous
(Clic here for more details about this article)

19/48. Study of preneoplastic changes of liver cells by immunohistochemical and molecular hybridization techniques.

    The status of hepatitis b virus dna was investigated by in situ hybridization in multifocal areas of a noncancerous hepatitis b virus-associated cirrhosis. This liver exhibited a marked degree of dysplasia and adenomatous hyperplasia. The results of these studies were correlated with the histopathology and immunohistochemical stains for hepatitis B core and surface antigens. There was clear evidence of a marked reduction to absence of hepatitis B viral dna by in situ hybridization and absence of HBc and HBsAg in the foci of liver cell dysplasia and adenomatous hyperplasia. These results support the hypothesis that liver cell dysplasia and adenomatous hyperplasia are preneoplastic in nature.
- - - - - - - - - -
ranking = 2.7744570999402
keywords = preneoplastic
(Clic here for more details about this article)

20/48. Macroregenerative nodules of the liver in primary biliary cirrhosis: report of two autopsy cases.

    Recently, macroregenerative nodules of the liver have been regarded as putative precancerous lesions in human cirrhotic livers. We describe the morphologies of two macroregenerative nodules, one benign and another harboring a malignant hepatocellular focus, occurring in two patients with primary biliary cirrhosis, both at the cirrhotic stage. The macroregenerative nodules of both patients were found incidentally at autopsy. The macroregenerative nodule of case 1 (42-yr-old female) was composed of hyperplastic hepatocytes with little atypia. The macroregenerative nodule of case 2 (67-yr-old male) had a malignant focus, in addition to atypical hepatocytes. The atypical hepatocytes showed mild nuclear crowding, slightly increased nucleocytoplasmic ratio, and mild nuclear hyperchromasia. The malignant focus was free of stainable iron against the mildly siderotic background. These findings may support the concept that macroregenerative nodules can also be a preneoplastic lesion in primary biliary cirrhosis.
- - - - - - - - - -
ranking = 1.054891419988
keywords = preneoplastic, precancerous
(Clic here for more details about this article)
<- Previous || Next ->


Leave a message about 'Precancerous Conditions'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.