Cases reported "Precancerous Conditions"

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21/48. Disseminated atypical tuberculosis-antedating the clinical onset of neoplasia.

    Two cases of disseminated atypical tuberculosis are presented in which the infection anteceded by over four years the development of acute granulocytic leukemia on one and Hodgkin's disease in the other patient. The presence of disseminated atypical mycobacteriosis in the absence of a clearcut underlying illness suggests a "preneoplastic state." It should alert the clinician to the possibility of a neoplastic disorder which may not become clinically manifest for several years.
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ranking = 1
keywords = preneoplastic
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22/48. Cytophotometric investigations on a chronic tubular nephropathy simulating preneoplastic condition.

    Cytophotometric investigations were performed on the atypical renal tubular epithelium of a young man who died of renal failure, possibly due to chronic lead exposure. The aim of this analysis was to determine whether nuclear atypia indicates incipient malignancy or is a type of so-called "benign atypias". dna histogram, showing euploid polyploidy supports the latter view and the dysplastic epithelial lesion is not even considered to be a preneoplastic condition.
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ranking = 5
keywords = preneoplastic
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23/48. Management and care of the precanceroses of the stomach in the 11-year material of our clinic.

    The present paper surveys over the past 11 years the cases of the endoscopic laboratory of our clinic which, according to criteria accepted all over the world, were considered as precancerous states of the stomach. According to the authors' experience, an advance in the management of malignant diseases can only be expected by referring to operation the cases in their early stage, if the examination and regular control of the patients are carried out with the predisposing factors being considered by a team involving the surgeon, endoscopist and pathologist.
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ranking = 0.90107718733654
keywords = precancerous
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24/48. Clinical criteria in diagnosis of early squamous cell carcinoma of the lower lip.

    Squamous cell carcinoma of the lower lip may be unsuspected and undiagnosed in its early clinical stages and may appear in occult and noncharacteristic forms. Specific risk factors and characteristics of lesions were sought after clinical and histologic data were correlated in a survey of patients with precancerous and cancerous lesions of the lower lip.
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ranking = 0.90107718733654
keywords = precancerous
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25/48. Atypical monoclonal plasma cell hyperplasia of the central nervous system: precursor of plasmacytoma with evolutionary considerations.

    Hematopoietic proliferations rich in plasma cells rarely occur within the central nervous system without the involvement of other organ systems. Depending on their histological pattern and cellular composition, several different terms, including plasmacytoma, plasma cell granuloma, hyalinizing plasmacytic granulomatosis, and inflammatory meningioma, are used for these lesions. We report a left temporal dural lesion composed of plasma cells, lymphocytes, histiocytes, and rare eosinophils with hyaline changes and a suggestion of follicle formation, which stained predominantly for IgG and kappa light chains. This lesion arose in an otherwise healthy 52-year-old woman. Free kappa light chains without a monoclonal peak were found in the urine. We are aware of only two other heterogeneous, predominantly plasmacytic, solitary dural lesions that were found to be monoclonal on immunohistochemical examination. The label atypical monoclonal plasma cell hyperplasia appears to suit the morphological characteristics of our lesion. We suggest that a spectrum of solitary plasmacytic lesions may occur within the central nervous system and that atypical plasma cell hyperplasias have the potential to evolve into plasmacytoma. The preneoplastic nature of this lesion and its potential for evolution to malignant myeloma should be considered when planning treatment and lifelong follow-up for patients.
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ranking = 1
keywords = preneoplastic
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26/48. oral submucous fibrosis in a 4-year-old girl.

    A rare case of oral submucous fibrosis in a 4-year-old Indian girl is presented. The condition is defined, and the clinical and laboratory features are discussed. Different treatment modalities and current theories of etiology are presented. Finally, the importance of regarding this condition as a precancerous lesion is supported.
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ranking = 0.90107718733654
keywords = precancerous
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27/48. Inverted papillomas of the urinary tract. A case of multiple, recurring inverted papillomas of the renal pelvis, ureter and bladder associated with malignant change.

    A case of multiple, recurring urothelial inverted papillomas is reported with localization in the bladder, ureter and renal pelvis. association of several of these with areas of transitional cell tumours and final occurrence of pure transitional cell tumour of papillary and non-papillary type grade II, causes us to question the original concept of inverted papillomas as benign tumours and lean to the more recent concept of inverted papillomas representing precancerous lesions.
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ranking = 0.90107718733654
keywords = precancerous
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28/48. Enzyme pattern and marker antigens in nodular "regenerative" hyperplasia of the liver.

    Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was demonstrated in a case of nodular "regenerative" hyperplasia of liver. The lack of marker antigens (alphafetoprotein, carcinoembryonic antigen, alpha 1-antitrypsin) in the hyperplastic nodules in this patient may be related to the discontinuation of oral contraceptive steroids four years earlier. The phenotypic changes of enzyme activity suggest that nodular "regenerative" hyperplasia of the liver in man is preneoplastic.
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ranking = 2
keywords = preneoplastic
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29/48. Inflammatory bowel disease (ulcerative colitis).

    There is uncertainty as to the proper management of a patient with chronic ulcerative colitis who has had his disease for over ten years but has not been sufficiently symptomatic to warrant colectomy. Not all patients are at high risk to develop cancer. Wide extent and long duration of disease are correlated with increased risk. The ability to define a patient at risk beyond these single criteria are very limited. The definition and efficacy of the precancerous lesion observed in rectal biopsies is still a matter of dispute, and the routine use of proctocolectomy for patients with long-standing colitis is still not universally accepted. Careful follow-up is obviously indicated, but it is still uncertain whether roentgenography, colonoscopy, colonic biopsy, or a combination of these methods will ultimately prove the procedure of choice.
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ranking = 0.90107718733654
keywords = precancerous
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30/48. adenoma with multiple hyperplastic nodules in noncirrhotic liver possibly related to long-term administration of a hypolipidemic drug.

    Described here is an autopsy case of a 76-year-old woman with preneoplastic and other adenomatous hepatocellular lesions. Multiple small hyperplastic liver foci with PAS positive reaction and adenomatous nodular lesions were noted in a non-cirrhotic liver. These lesions resembled altered foci or neoplastic nodules which are currently regarded as premalignant changes in experimental animal models. It is suggested that the liver lesions of this woman may be related to long-term administration of hypolipidemic drug clofibrate for hypercholesteremia and the lesions could be one of the precursor changes of human hepatocellular carcinoma.
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ranking = 1
keywords = preneoplastic
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