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1/7. pregnancy in a woman with a y chromosome after removal of an ovarian dysgerminoma.

    BACKGROUND: It appears to be a general belief that pregnancy might be impossible in women with the XY karyotype. Therefore, it is recommended that patients with dysgerminoma of the ovary associated with the XY karyotype should undergo a bilateral salpingo-oophorectomy. CASE: We report an extremely rare case of a true hermaphrodite with a 20% 46,XX/80% 46,XY karyotype who became pregnant after removal of an ovarian dysgerminoma. The patient had a completely normal female phenotype. A dysgerminoma with ovotestis was found in the right ovary. Two courses of chemotherapy following a right salpingo-oophorectomy were carried out. Nine months later she became pregnant and delivered a healthy male infant. CONCLUSION: A unilateral salpingo-oophorectomy followed by combination chemotherapy can be the treatment of choice for any woman who wishes to preserve her capacity for conception at the time of operation for dysgerminoma of the ovary.
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keywords = dysgerminoma
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2/7. gonadoblastoma and fertility.

    Most patients with gonadoblastoma have dysgenetic gonads. This rare tumour has been described in three pregnant women. A fourth case in a 26 year old pregnant woman who presented with gonadoblastoma and dysgerminoma, is reported. She had a normal term pregnancy, 46XX chromosomes, normal genitalia, no history of menstrual irregularities and no signs of hyperandrogenism, thereby differing from the other reported cases. The germ cell component of this patient's tumour had undergone rapid overgrowth, most of the tumour comprising pure dysgerminoma. It is suggested that gonadoblastoma may occur in functionally and morphologically normal gonads more often than previous case reports imply.
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ranking = 0.25
keywords = dysgerminoma
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3/7. Management of ovarian dysgerminoma during a pregnancy complicated by preeclampsia; a case report.

    A case of a 25-year-old primigravid woman at 31 weeks' gestation with the diagnosis of preeclampsia, malignant pelvic mass, fetal growth restriction and postpartum pulmonary thromboembolism is reported. fertility preserving surgery for ovarian carcinoma following cesarean delivery was carried out. Final histopathology revealed Stage IC dysgerminoma. After eight months of initial surgery she became pregnant spontaneously. After two years of initial surgery she is still alive without any evidence of disease.
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ranking = 0.625
keywords = dysgerminoma
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4/7. karyotyping and dna flow cytometry of metastatic ovarian yolk sac tumor.

    We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [dna index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.
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ranking = 0.125
keywords = dysgerminoma
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5/7. Ovarian gonadoblastoma with dysgerminoma in a woman with two normal children.

    An unusually rare case of unilateral gonadoblastoma with dysgerminoma occurring in the ovary of a 28-year-old woman with two normal children is reported.
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ranking = 0.625
keywords = dysgerminoma
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6/7. Pregnancies following conservative treatment of malignant ovarian tumors.

    Sixteen patients with malignant ovarian tumors were treated conservatively; 1 had a serous cystadenoma of low potential malignancy; 6 had a mucinous cystadenoma of low potential malignancy; 2 had a pure dysgerminoma; 2 had a mature solid teratoma; 3 had a mucinous cystadenocarcinoma; and 2 had an endodermal sinus tumor. Postoperative chemotherapy was given in 12 cases and 1 patient with a pure dysgerminoma had radiotherapy. Eighteen pregnancies occurred in 13 patients. One full-term and one 8 month premature infant died in utero, and 2 infants had malformations; the other 14 infants are all well. The patient with moderately differentiated mucinous cystadenocarcinoma who delivered a premature infant and 2 patients with endodermal sinus tumors died of recurrence.
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7/7. dysgerminoma of the ovary: incidental finding during cesarean section.

    Two cases are presented of dysgerminoma found incidentally at the time of cesarean section. The first was an elective repeat operation and in the second case operation was carried out for fetal distress. In both cases a unilateral salpingooophorectomy was performed. Both patients have been free of recurrence 3 years following the diagnosis. One of them delivered a healthy baby 2 years after the operation. Since dysgerminoma is more prevalent among young females, its coexistence with pregnancy is more expected. early diagnosis and treatment for pure dysgerminoma provides a good prognosis and fertility can be preserved in selected cases.
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ranking = 0.375
keywords = dysgerminoma
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