Cases reported "Psoriasis"

Filter by keywords:



Filtering documents. Please wait...

21/40. Concomitant psoriasis and bullous pemphigoid: coincidence or pathogenic relationship?

    psoriasis vulgaris and bullous pemphigoid represent two clinically well-characterized, chronic, inflammatory skin diseases. The concomitant occurrence of these two entities in a patient is rare, and the pathogenic implications of this phenomenon are unknown. We describe a 55-year-old woman with a 25-year history of plaque-type psoriasis who presented with disseminated tense bullae. Skin biopsies showed the typical histologic and immunohistochemical traits of bullous pemphigoid, and she had circulating immunoglobulin g (IgG) antibodies against the basement membrane zone, specifically the BP180 antigen. The bullous eruption was successfully treated with oral methylprednisolone and dapsone. Bullous pemphigoid is the autoimmune blistering disease that has most often been associated with psoriasis. Forty cases have been described in the literature. Classical psoriasis and psoriasis associated with bullous pemphigoid are identical. The pathogenic relationship between psoriasis and bullous pemphigoid is unclear. It has been postulated that the autoimmune process responsible for bullous pemphigoid lesions may be induced by ultraviolet light therapy, topical corticosteroids, and/or the inflammatory processes that occur in psoriasis. Immunomodulatory therapy may positively influence shared as well as distinct inflammatory mechanisms in patients who have psoriasis and bullous pemphigoid.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

22/40. Lymphocytic infiltrates of the skin in association with cyclosporine therapy.

    Three patients, one of whom has been previously reported, had erythematous papules and nodules of the face and upper part of the chest during cyclosporine therapy for inflammatory skin diseases. Histologic examination and dna analysis (performed in two cases) revealed benign dermal lymphocytic infiltrates. In two cases proliferation of only T cells occurred. In the third case, both T and B cell populations were expanded and there was vacuolar degeneration of the basal layer of the epidermis and IgG, IgM, and C3 deposition along the dermoepidermal junction. These findings may be the result of cyclosporine-induced immune dysregulation. The lesions resolved in all patients after therapy was stopped.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

23/40. Altered theophylline metabolism in patients with psoriasis.

    We observed two patients on theophylline therapy with concomitant severe psoriasis and a two- to threefold greater theophylline clearance than that reported in healthy, nonsmoking adults. There were no factors known to induce theophylline clearance. In both cases, the induction of theophylline metabolism was relatively selective for the 1-methyluric acid pathway. The altered metabolism in these patients appeared to correlate with the clinical severity of the disease. The data suggest the possibility that an observed lack of efficacy for theophylline in psoriasis may be related to pharmacokinetic effects. The concept that altered drug metabolism may occur in the presence of skin disease has important implications for pharmacotherapeutics in dermatology.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

24/40. Pustular psoriasis of v. Zumbusch type associated with recurring cholestatic jaundice.

    A 46-year-old man with pustular psoriasis and recurring episodes of severe cholestatic liver disease is described. Six icteric periods have occurred parallelling high activity of the skin disease.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

25/40. Polymorphonuclear leukocyte chemotaxis in generalized pustular psoriasis.

    We studied polymorphonuclear leukocyte (PMNL) chemotaxis in 3 patients with generalized pustular psoriasis using 3 chemoattractants: zymosan-activated serum from both the patients and normal individuals, and n-formyl-methionyl-leucyl-phenylalanine (FMLP). These attractants were assayed against both patient-derived and normal PMNLs. All patients had quiescent skin disease at the time of assay. We found that all patients had decreased PMNL chemotaxis to autologous zymosan-activated serum, but not to FMLP. PMNLs from normal individuals responded normally to serum from the patients. We conclude that patients with generalized pustular psoriasis, when free of symptoms, may have an isolated PMNL chemotactic defect that is restricted to serum-derived attractants.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

26/40. Successful treatment of a patient with Reiter's syndrome and acquired immunodeficiency syndrome using etretinate.

    In a 30-year-old homosexual man with a 3-year history of localized psoriasis, an oligoarthropathy and severe cutaneous lesions of Reiter's syndrome developed 6 months after acquired immunodeficiency syndrome (AIDS) was diagnosed. Reiter's syndrome and psoriasis may be a continuum of similarly expressed cutaneous diseases that develop in genetically predisposed individuals. We discuss the possible involvement of T lymphocytes and langerhans cells in the cutaneous lesions of AIDS patients with psoriasis and Reiter's syndrome. In these AIDS patients, skin disease tends to be severe and recalcitrant to conventional therapy. etretinate plus topical fluorinated steroids was an excellent treatment, producing near clearance of skin lesions and significant improvement in the oligoarthropathy.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

27/40. Subungual trichogranuloma in a hairdresser.

    Hairdressers may be subject to occupational skin diseases other than contact dermatitis. Interdigital trichogranuloma is a common disorder among those who cut men's hair but is much less common among those who cut women's hair. Interdigital trichogranulomas or interdigital sinuses are the result of penetration of the skin by short, sharp hair clippings. Subungual hair penetration appears to be much less common. This article reports the first case of subungual trichogranuloma in a hairdresser with psoriatic onycholysis. onycholysis may be both a risk factor for and a consequence of cut hairs becoming imbedded subungually.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

28/40. Rapid occurrence of nodular cutaneous T-lymphocyte infiltrates with cyclosporine therapy.

    cyclosporine, a potent immunosuppressive agent, has been successfully used in the treatment of several dermatologic conditions including psoriasis. However, the drug does have an array of toxic side effects that need to be carefully considered when determining the risk-benefit ratio for the treatment of skin disease. We present another potential adverse effect of cyclosporine, namely, a benign lymphocytic infiltrate. This eruption developed in a patient with psoriasis after only ten days of cyclosporine therapy. The exact mechanism by which cyclosporine induced the lymphocytic infiltrate is unknown, but it is postulated that cyclosporine caused an imbalance of T-cell regulatory systems, thus resulting in an expanded T-cell subpopulation and the clinical manifestation of erythematous papules and nodules.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

29/40. psoriasis and intraocular inflammation.

    Presented in this series were seven men and three women. Ages when seen, ranged from 32 to 68 years (average 54). psoriasis had begun in childhood in the women and in the late 20's and 30's in the men. arthritis (ankylosing spondylitis) was present in only one. Their ocular inflammations began from ages 26 to 62 (average 41). The onset of the inflammation was acute iritis in four and in indolent iridocylcitis in six. All but one were bilateral and chronic. The vitreous had heavy debris in nine of the ten patients. The retina was normal in only three. Boggy congestion was present in two with cystoid edema. Patches of edema. fluorescein leaking, depigmentation of both maculae, pars plana exudate, and retinal vessel obliteration to grey-white, shaggy cords was present in at least one of the remaining five patients. Systemic corticosteroid therapy has been used in eight of the ten patients described in this report. Doses no higher than 30 mg of prednisone per day were used to initiate reversal of the inflammatory response. In case 10, knowledge of the sensitivity of the process to steroids led to the successful rapid reversal of a recalcitrant iritis with only 20 mg of prednisone as a first dose and 20 mg per day for less than three weeks. maintenance corticosteroid therapy ranged from 40 mg of prednisone every other day in case 9, prednisone 12.5 mg one day and 5 mg the next in case 8, to 8 mg of Aristocort or methylprednisolone acetate (M-edrol) daily in cases 1 and 2. In summary, these patients are older, have an indolent onset bilateral uveitis with dense vitreous debris, retinal abnormalites, and are extremely sensitive to systemic corticosteroids. Many of these patients had undergone the series of clinical evaluations known as a "uveitis survey." Many different systemic abnormalities were found and merited treatment which rarely made a difference in their ocular disease, though two improved after infected teeth were treated. Assuming that these ocular diseases were related to psoriasis, one can then challenge the value of anything found by a "uveitis survey." The author uses information gained from such studies to insure that the patient is in the best possible heatlh and then makes clinical correlations such as presented in this paper. The rarity of this combination of ocular inflammations in patients with psoriasis makes it risky to propose that this is a significant association. Arguments that this is a disease entity began with the clinical similarities: older age, indolent onset, vitreous and retinal involvement, and the extreme sensitivity to systemic corticosteroids. None of these patients had psoriatic arthritis and only one had ankylosing spondylitis. The best explanation for the fact that this disorder has not been emphasized in the past would be an attitude of ophthalmologists and physicians that the eye and skin disease were coincident.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)

30/40. Therapeutic trials with oral colchicine in psoriasis.

    Twenty-two psoriatic patients were treated orally with the antichemotactic agent, colchicine, at a dosage of 0.02 mg per kg per day for a duration of 2-4 months. Complete clearing or marked improvement were noted in 8 of the 9 patients, in whom thin papules and thin plaques were the predominant type of lesion. Much less favorable results were obtained in patients with chronic, stable, thick plaque-type disease, although decreased scaliness, erythema and infiltration and marked diminution of the pruritus were observed in almost all of the cases. A considerable improvement of the joint pains was noted in each of the 8 patients who suffered from arthralgias. Five additional patients with extensive, chronic, stable plaque-type psoriasis were given oral colchicine immediately after complete clearing of their skin lesions with Goeckerman's method or with methotrexate. Four of them continued to take colchicine for 8-9 months and during that time they remained free of significant skin disease. These findings lend support to the hypothesis that the migration of the activated psoriatic neutrophils into the skin could be an important factor in the initiation and possibly also in the perpetuation of the psoriatic lesions. Closely controlled, long-term studies conducted in large numbers of patients are warranted in order to determine the exact therapeutic role of oral colchicine in the long-term management of psoriasis.
- - - - - - - - - -
ranking = 1
keywords = skin disease
(Clic here for more details about this article)
<- Previous || Next ->


Leave a message about 'Psoriasis'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.