Cases reported "Retinal Neoplasms"

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1/4. Transretinal feeder vessel ligature in von hippel-lindau disease.

    PURPOSE: To present a new technique called transretinal feeder vessel ligature for the treatment of retinal angiomas. methods: Case report of a patient with peripheral retinal angiomas previously treated unsuccessfully with photocoagulation who responded to this new, alternative surgical treatment. RESULTS: The retinal angiomas decreased in size although two new feeder vessels appeared and the lesions showed a regression pattern after additional laser therapy over the vascular tumors. CONCLUSIONS: A transretinal feeder vessel ligature in association with vitrectomy and photocoagulation may be useful for some advanced or non-responsive cases of retinal angiomas.
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2/4. Segmentation techniques for tissue differentiation in MRI of ophthalmology using fuzzy clustering algorithms.

    This paper presents MRI segmentation techniques to differentiate abnormal and normal tissues in ophthalmology using fuzzy clustering algorithms. Applying the best-known fuzzy c-means (FCM) clustering algorithm, a newly proposed algorithm, called an alternative fuzzy c-mean (AFCM), was used for MRI segmentation in ophthalmology. These unsupervised segmentation algorithms can help Ophthalmologists to reduce the medical imaging noise effects originating from low resolution sensors and/or the structures that move during the data acquisition. They may be particularly helpful in the clinical oncological field as an aid to the diagnosis of retinoblastoma, an inborn oncological disease in which symptoms usually show in early childhood. For the purpose of early treatment with radiotherapy and surgery, the newly proposed AFCM is preferred to provide more information for medical images used by Ophthalmologists. Comparisons between FCM and AFCM segmentations are made. Both fuzzy clustering segmentation techniques provide useful information and good results. However, the AFCM method has better detection of abnormal tissues than FCM according to a window selection. overall, the newly proposed AFCM segmentation technique is recommended in MRI segmentation.
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3/4. Preimplantation genetic diagnosis for retinoblastoma: the first reported liveborn.

    PURPOSE: To develop an accurate mutation analysis procedure for retinoblastoma gene (RB1) mutation, which is sensitive at the single-cell level, and to use in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) to achieve pregnancies without retinoblastoma. DESIGN: Case report. methods: Twelve day 3 embryos, obtained by IVF with intracytoplasmic sperm injection, underwent single-cell dna testing via polymerase chain reaction and restriction enzyme analysis to detect the presence of a paternal RB1 mutation. Embryos were diagnosed as being unaffected and were transferred to the uterus on day 5. MAIN OUTCOME MEASURES: Achieving a healthy pregnancy and delivery, assessed by clinical presentation, fundus photography, and RB1 molecular analysis. RESULTS: A singleton pregnancy was achieved, and a child without retinoblastoma was born. The absence of the paternal RB1 mutation was confirmed on a sample of peripheral blood from the newborn. CONCLUSIONS: We are first to report a successful human liveborn, delivered after IVF with preimplantation genetic diagnosis for retinoblastoma. The successful result indicates that preimplantation genetic diagnosis exists for this genetic disease and may represent a viable alternative to prenatal diagnosis with the subsequent option of terminating an affected pregnancy.
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4/4. Retinal capillary angioma in familial exudative vitreoretinopathy treated with photodynamic therapy.

    PURPOSE: To report a case of familial exudative vitreoretinopathy with a retinal capillary angioma and persistent macular exudation treated with photodynamic therapy. DESIGN: Interventional case report. methods: A 39-year-old woman with familial exudative vitreoretinopathy presented with an intraretinal capillary angioma temporally with persistent macular exudation despite previous vitrectomy and thermal laser. Photodynamic therapy to the retinal angioma was performed. RESULTS: Three months after photodynamic therapy, vision was stable at 20/200 with a reduction in lesion size on B-scan ultrasonography and no leakage on fluorescein angiography. With 10 months of follow-up there was no recurrence of leakage. CONCLUSION: Retinal capillary angioma may be present in association with familial exudative vitreoretinopathy, and photodynamic therapy may provide a good alternative treatment to decrease exudation.
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