11/21. Macular hole formation following thermal laser photocoagulation in a patient with choroidal neovascular membrane and age-related macular degeneration.A woman with age-related macular degeneration and an extrafoveal choroidal neovascularization was treated with thermal laser photocoagulation. Three years later, an optical coherence tomography image showed a full-thickness macular hole with some contracture toward the adjacent atrophic laser scar, suggestive of some presumptive tangential forces.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
12/21. Fundus autofluorescence imaging findings in retinal pigment epithelial tear.PURPOSE: Retinal pigment epithelial (RPE) tear is a clinical and angiographic entity, which usually occurs in association with pigment epithelial detachments (PED), in the context of neovascular age-related macular degeneration (ARMD). The recording of fundus autofluorescence (FAF) has been introduced as a technique of retinal imaging, allowing the in vivo assessment of the integrity of RPE. The authors describe the FAF imaging findings in a patient with RPE tear. methods: Observational case report. RESULTS: A 70-year-old woman developed RPE tear after the application of photodynamic therapy for choroidal neovascularization associated with PED. The diagnosis of the RPE tear was confirmed by fluorescein angiography (FA) and indocyanine green angiography (ICGA). FAF imaging revealed absence of autofluorescence at the area which was denuded of RPE, while at the area where the RPE was rolled, a heterogeneous signal of FAF was recorded. The intensity of the signal in that area was, on average, not different from the normal background FAF signal expected in an unaffected RPE/photoreceptor complex. CONCLUSIONS: The authors report the FAF imaging findings in a patient with RPE tear. These findings can be interpreted from the ability of FAF imaging to access in vivo the integrity of RPE, and correlate well with the histopathology of this clinical entity. FAF imaging, as a fast and noninvasive technique, may be a useful modality, alternative to FA and ICGA, in the diagnosis and evaluation of such cases. Moreover, it may contribute to a more detailed phenotyping of the various clinical pictures associated with neovascular ARMD.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
13/21. Retinal pigment epithelial tear following intravitreal injection of bevacizumab (Avastin).PURPOSE: To report one case of retinal pigment epithelium tear following intravitreal bevacizumab injection for neovascular age-related macular degeneration. methods: A 59-year-old patient presented with occult choroidal neovascularization associated with a serous pigment epithelial detachment secondary to age-related macular degeneration. The patient was treated with an intravitreal injection of bevacizumab. RESULTS: The patient developed a retinal pigment epithelium tear 60 days following the intravitreal injection. CONCLUSIONS: This report describes the development of retinal pigment epithelium tear after intravitreal bevacizumab injection. Future studies should be performed to evaluate which subtypes of lesions are most susceptible to this potential devastating visual complication.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
14/21. Retinal pigment epithelial tear after intravitreal bevacizumab injection.PURPOSE: To report two cases of a retinal pigment epithelial (RPE) tear after intravitreal bevacizumab injection for exudative age-related macular degeneration (AMD). DESIGN: Observational case series. methods: Two patients presented with occult choroidal neovascularization secondary to AMD. Both patients received intravitreal bevacizumab injections. RESULTS: The first patient developed a RPE tear shortly after a third intravitreal bevacizumab injection. The second patient developed a RPE tear 10 days after a second intravitreal bevacizumab injection. CONCLUSIONS: Although RPE tears may occur spontaneously as part of the natural history of exudative AMD, patients may develop visually devastating RPE tears after repeat intravitreal bevacizumab injection. Further studies are needed to determine the incidence of RPE tears after intravitreal bevacizumab injections.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
15/21. Peripheral retinal neovascularization and rubeosis iridis after a bilateral circular buckling operation.This report describes a young high-myopic patient who developed rubeosis iridis with peripheral retinal neovascularization one year after a circular buckling operation. Subsequently, vitreous bleeding and exudation led to traction retinal detachment which was treated successfully by anterior vitrectomy and cryopexy. It is suggested that this case represents a mild form of anterior-segment ischemia, combined with peripheral retinal ischemia.- - - - - - - - - - ranking = 5keywords = neovascularization (Clic here for more details about this article) |
16/21. Posterior tractional retinal breaks complicating branch retinal vein occlusion.A total of 358 patients with branch retinal vein occlusion (BRVO) were reviewed to examine the relationship between branch retinal vein occlusion with neovascularization elsewhere (NVE), vitreous hemorrhage, and posterior tractional retinal breaks. Twenty-eight of 358 (7.8%) BRVO patients had vitreous hemorrhage. In this group of 28 patients, 24 of the 28 (85.7%) had NVE. Of the 24 BRVO patients with vitreous hemorrhage and NVE, six (21.4%) were found to have posterior tractional retinal breaks adjacent to avulsed neovascular tissue. These data indicate a strong association between BRVO patients with vitreous hemorrhage and posterior tractional retinal breaks due to avulsion of neovascular tissue.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
17/21. Confocal laser tomographic analysis of the retina in eyes with macular hole formation and other focal macular diseases.To study the retinal surface in the human eye in normal and diseased states we used laser scanning tomography. The confocal arrangement of the laser tomographic scanner permits examination of retinal topography in the axis perpendicular to the retinal surface. The eyes examined with the laser tomographic scanner included normal eyes, eyes with macular holes, impending macular holes, radiation retinopathy, macular edema, photocoagulation scars, subfoveal scars, and serous detachment of the fovea associated with subretinal neovascularization. The laser tomographic scanner is a new method that allows measurements of the topography of the internal limiting membrane in the macular area and may improve our understanding of the pathophysiologic characteristics and treatment of a variety of disorders of the macula.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
18/21. choroidal neovascularization in an eye with a macular hole.We report the case of a 68-year-old woman who initially presented with an idiopathic macular hole OD and atrophic macular degenerative changes and who subsequently developed subretinal neovascularization OU. The subretinal neovascularization evolved through the macular hole OD and decreased visual acuity to counts fingers, but the membrane was successfully treated OS with krypton laser photocoagulation and stabilization of visual acuity at 20/50 over the eight-year postoperative follow-up. This is the first report, to our knowledge, of a membrane developing through a macular hole. This may be a more common occurrence than reported due to obscuring of details from hemorrhage and exudate as part of the disciform process.- - - - - - - - - - ranking = 6keywords = neovascularization (Clic here for more details about this article) |
19/21. Corneal endothelial overgrowth of angle and iris. Evidence of myoblastic differentiation in three cases.Corneal endothelialization of the anterior chamber angle was observed in three cases of iris neovascularization and one case of post-contusion deformity. Scanning electron microscopy in two cases revealed a sheet composed of confluent fusiform cells forming a regular mosaic, growing in a tissue culture-like fashion, and extending over the anterior iris surface. Electron microscopy revealed an endothelial lining continuous with the corneal endothelium extending over the fibrovascular membrane which covered the anterior iris surface in the cases of iris neovascularization and partially extended over the trabecular meshwork in an eye with post-contusion deformity. These endothelial cells possess junctional complexes, apical villi, and prominent basement membrane. In addition, myoblastic differentiation with intracytoplasmic microfilaments, measuring 5 to 6 nm in diameter and often marginally located with fusiform densities, were observed. The presence of myoblastic features may play a role in the ability of corneal endothelial cells to migrate and participate in production of peripheral anterior synechia and ectropion of the iris.- - - - - - - - - - ranking = 2keywords = neovascularization (Clic here for more details about this article) |
20/21. Accidental Nd:YAG laser injuries to the macula.PURPOSE: To study the clinical course of accidental, single-focus Nd:YAG laser injuries to the macula. methods: We reviewed the clinical course of five eyes (four patients) that sustained macular injuries from a Nd:YAG laser. All patients were examined within 24 hours of injury and were observed without surgical intervention for a mean of 20 months (range, 12 to 32 months). RESULTS: A single full-thickness foveal or parafoveal retinal hole was apparent in all eyes either on initial examination or within two weeks of injury. All macular holes were within 650 microns of the foveal center. The mean final visual acuity was 20/60 (range, 20/25 to 20/400) and was related to the distance between the macular hole and the foveal center. None of the eyes developed either subretinal neovascularization or clinically significant epiretinal membrane formation during the study period. CONCLUSIONS: Despite initial poor visual acuity in patients who had a full-thickness foveal or parafoveal retinal hole, visual acuity improved without treatment when the site of the laser injury was located outside the foveal center.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
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