1/10. Diode laser photocoagulation for retinopathy of prematurity: a histopathologic study.Laser photocoagulation has largely supplanted cryotherapy as an effective treatment for retinopathy of prematurity. This case describes the ocular histopathologic findings of a pair of eyes in a severely premature male infant treated with diode laser photocoagulation for bilateral stage 3 retinopathy of prematurity (ROP) for 360 degrees in zone 1 with severe plus disease. The right eye responded to treatment; the left eye developed persistent vitreous hemorrhage and total retinal detachment. The histopathologic examination of laser burns in the right eye disclosed segmental areas of chorioretinal scarring with retinal atrophy and gliosis, loss of RPE and extensive atrophy of the choroid and its vasculature, which involved both the choriocapillaris and larger vessels. The left eye had iris neovascularization, a chronic organized vitreous hemorrhage and a totally detached retina. The histopathologic findings in an eye of a premature infant with threshold ROP treated with diode laser photocoagulation resembled those reported after transsceral cryotherapy. Diode laser photocoagulation may produce less severe chorioretinal damage.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
2/10. Severe retinopathy in a child with hypoplastic left heart syndrome.PURPOSE: We present the first reported case of a condition similar to retinopathy of prematurity in a full-term patient with hypoplastic left heart syndrome. DESIGN: Interventional case report. methods: We describe the clinical presentation and surgical treatment of a male baby with severe retinopathy and retinal detachments. RESULTS: The clinical course of this baby was similar to retinopathy of prematurity. The patient had areas of avascular retina, significant retinal neovascularization, fibrous proliferation, and tractional detachment. One eye had a totally detached retina; the other had functional vision after the retina was reattached by several vitreoretinal surgeries, including the use of intraocular silicone oil. CONCLUSIONS: This cyanotic condition can cause a retinopathy with chronic retinal neovascularization and retinal detachments. Permanent surgical retinal reattachment is difficult in the presence of neovascular activity that leads to intravitreous cicatrization.- - - - - - - - - - ranking = 2keywords = neovascularization (Clic here for more details about this article) |
3/10. Zone 1 retinopathy of prematurity in a transitional economy: a cautionary note.PURPOSE: To describe three low risk infants in whom severe retinopathy of prematurity developed. DESIGN: A prospective, observational case series. methods: setting: National Hospital of pediatrics, Hanoi, vietnam. study population: Premature infants in the neonatal ward. observation procedure: eye examinations. RESULTS: Severe retinopathy of prematurity occurred in three infants. All had zone 1 disease and other unusually severe findings, such as neovascularization of the disk. These infants would not be at risk for the development of such severe retinopathy of prematurity in countries with a developed economy. CONCLUSIONS: Unusual characteristics of retinopathy of prematurity may be occurring in countries with transitional economies. Screening programs should be implemented and should take into consideration the possibility that retinopathy of prematurity may occur in infants who fall outside the screening guidelines that are used in the developed world.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
4/10. Management of late-onset angle-closure glaucoma associated with retinopathy of prematurity.Late-onset angle-closure glaucoma secondary to retinopathy of prematurity (ROP) occurred in ten eyes of ten patients. The age at presentation ranged from 12 to 45 years (mean, 32 years). Eight eyes had nonneovascular mechanisms for the angle closure while two had neovascular angle closure. Treatment of eyes with this form of secondary angle closure included medical management alone, peripheral iridectomy, trabeculectomy, lensectomy, alloplastic tube shunt implantation, and cilioablative procedures. Three eyes required more than one of these treatments. The choice of therapy was based on the initial intraocular pressure and vision, degree of lens opacity and intumescence, presence of anterior segment neovascularization, and the gonioscopic appearance of the anterior chamber angle. The clinical features of this condition are described and a proposed mechanism and therapeutic approach are presented.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
5/10. Scanning electron microscopy of the ocular vasculature in retinopathy of prematurity.Clinicoanatomopathologic correlations in a case of the retinopathy of prematurity are reported. A premature infant delivered at 28 weeks of gestation (weight, 900 g) was hospitalized for a number of health problems, including bronchopulmonary dysplasia and respiratory distress syndrome. Ophthalmic examination, at the age of 5 months, disclosed stage 1B retinopathy of prematurity. The patient died at the age of 161 days; both eyes were taken for scanning electron microscopy and histopathologic studies. Scanning electron microscopy findings included absence of retinal capillaries, anterior uveal neovascularization originating from the venous side, and a coincidental typical coloboma of the optic nerve and choriocapillaris. Histopathologic findings confirmed iris stromal neovascularization, showed retinal neovascularization with proliferation into the vitreous and avascular areas between the midperiphery and ora serrata.- - - - - - - - - - ranking = 3keywords = neovascularization (Clic here for more details about this article) |
6/10. The simultaneous presentation of retinopathy of prematurity and central serous chorioretinopathy.A case report of central serous chorioretinopathy (CSC) and retinopathy of prematurity (ROP) in the same patient is presented. CSC is a disease of the outer retinal layers, specifically the retinal pigment epithelium, which results in serous detachment of the neurosensory retina. ROP is a disease of the anterior retinal layers, affecting the retinal vasculature. Ocular manifestations may range from the peripheral neovascularization observed in the milder states to retinal detachment and secondary angle closure glaucoma that is often found in the later stages. Therefore it would appear that there is no direct relationship between the presence of ROP and the presence of CSC in a patient who presented with complaints of a unilateral relative central scotoma. To our knowledge this represents a heretofore unreported association.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
7/10. Exudative retinal detachment in retrolental fibroplasia.Four cases of exudative retinal detachment associated with retrolental fibroplasia are presented. The exudation appears to be secondary to leakage from neovascularization as well as vitreous traction on normal retinal vessels. The range in age of onset was between 13 and 17 years, with three of the four cases occurring in patients 23 years of age or younger. Treatment is directed at eliminating the abnormal vasculature which, in our experience, has been accomplished best by an encircling scleral-buckling procedure. One patient, however, required vitrectomy because of the severe vitreous membranes and traction which were present.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
8/10. Angioma-like mass in a patient with retrolental fibroplasia.A 13-year-old boy had mild vitreous hemorrhage in the left eye, and a red angioma-like epiretinal mass in the equatorial zone of the temporal fundus. The retina anterior to the mass was nonvascularized, and similar nonvascularization of the pre-equatorial retina was present in the temporal quadrants of the fellow eye. fluorescein angiography showed intraretinal neovascularization along the margin of the perfused and nonperfused retina and leakage from portions of the angioma-like mass, suggesting that it was composed of neovascular tissue and adjacent hemorrhage. The patient had been a premature infant, with a birth weight of 1,092 g, supporting the presumptive diagnosis of previously asymptomatic retrolental fibroplasia. Photocoagulation was successful in obliterating the neovascular tissue.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
9/10. Diode laser photocoagulation for retinopathy of prematurity.Recent studies have suggested that laser photocoagulation may be a favorable alternative to cryotherapy in the treatment of progressive extraretinal neovascularization in retinopathy of prematurity. Preliminary results of 10 eyes from 5 patients with so called "threshold" retinopathy of prematurity treated with indirect diode laser are reported. All 5 patients were less than 30 weeks gestational age. laser therapy was performed on the avascular retina in both eyes. Nine eyes had one session of treatment with regression of neovascularization within 6 weeks. All eyes had good anatomical results in the posterior pole at the end of follow-up. One eye had 2 treatment sessions; neovascularization regressed after the second treatment. Mild disc dragging was noted. This report recommends the use of diode laser photocoagulation in the treatment of retinopathy of prematurity.- - - - - - - - - - ranking = 3keywords = neovascularization (Clic here for more details about this article) |
10/10. Complications of indirect laser photocoagulation.Potential complications of indirect laser photocoagulation for retinopathy of prematurity are: corneal burn; iris burn; lens burn; choroidal hemorrhage or neovascularization; inadvertent photocoagulation of fovea; preretinal membrane formation; late onset retinal detachment; and retinal, preretinal, or vitreous hemorrhage.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
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