1/3. hypercalcemia, unusual bone lesions, and human T-cell leukemia-lymphoma virus in adult T-cell lymphoma.Extensive generalized and subperiosteal bone resorption was demonstrated in a patient with adult T-cell lymphoma and marked hypercalcemia of unclear pathogenesis. Antibody to the human T-cell leukemia-lymphoma virus (HTLV) was present in the serum of the patient, consistent with the recently reported association of adult T-cell lymphoma, hypercalcemia, and HTLV. The unique feature of this case was the presence of bone radiographic and pathologic findings consistent with hyperparathyroidism, in the absence of elevated parathormone levels. These findings contrast with the few previously reported cases of adult T-cell lymphoma with hypercalcemia, which showed lytic, sclerotic, or osteoporotic bone lesions. The authors suggest that the patient's malignant t-lymphocytes may have produced an osteoclast-activating-factor-like substance or a parathormone-like substance, which caused the striking bone changes. The exact role of HTLV in the pathogenesis of such cases remains to be determined.- - - - - - - - - - ranking = 1keywords = leukemia-lymphoma (Clic here for more details about this article) |
2/3. adult T-cell leukemia-lymphoma. Unusual features of two patients from a low-incidence area.The occurrence of adult T-cell leukemia-lymphoma in two new orleans patients, one native-born, the other originally from honduras, is reported. Both exhibited an unusual feature. One patient was diagnosed following an atypical episode of sinusitis and demonstrated lymphomatous infiltration of the nasopharynx. A second patient had a fulminant course complicated by severe diarrhea and was found to have both tumor involvement and cytomegalovirus inclusions in the colon. Both had high titers of antibodies to HTLV-I. A cell line with T-lymphocyte characteristics was established from the peripheral blood of the first patient. Such studies may help better establish the clinical course, detection, and epidemiologic features of this difficult disease.- - - - - - - - - - ranking = 1keywords = leukemia-lymphoma (Clic here for more details about this article) |
3/3. The human T-cell leukemia-lymphoma virus in the southeastern united states.The human T-cell leukemia-lymphoma virus (HTLV) is a recently described rna tumor virus associated with human T-cell malignant neoplasms. In two geographic areas, japan and the Caribbean basin, clusters of adult T-cell leukemia-lymphoma are "sentinel diseases" and have suggested an underlying prevalence of HTLV infection in both family members of the index cases and in the population. Four cases of lymphoma from the United States are described as illustrative of the sentinel disease. Serological studies of families and of a small population sample suggest that HTLV infection is endemic in certain parts of the southeastern united states at rates similar to those seen in Caribbean blacks but at a lower rate than that observed in southwestern japan.- - - - - - - - - - ranking = 1.2keywords = leukemia-lymphoma (Clic here for more details about this article) |