1/12. Histopathological findings in proliferative membrane from a patient with sarcoid uveitis.BACKGROUND: Sarcoid uveitis is occasionally accompanied by proliferative changes, such as retinal neovascularization and vitreous hemorrhage. Steroid administration, retinal photocoagulation, and vitrectomy may be indicated in such proliferative cases. CASE: A 19-year-old woman presented with proliferative sarcoid uveitis accompanied by recurrent vitreous hemorrhage. OBSERVATIONS: At the initial examination, bilateral vitreous opacity, retinal exudates, mild vitreous hemorrhage, retinal vasculitis, and neovascularization of the retina and optic disc were observed. Although prednisolone was administered and panretinal photocoagulation was performed several times, recurrent vitreous hemorrhage continued. Since the vitreous hemorrhage was not absorbed, pars plana vitrectomy and lensectomy were performed. After surgery, neovascularization and intraocular inflammation decreased, and the corrected visual acuity in the right eye improved to 20/50. Histopathologic analysis of the proliferative membrane removed during surgery revealed substantial neovascularization and numerous neutrophils in the vessels. CONCLUSIONS: Based on these findings, an inflammatory reaction as well as retinal ischemia were thought to be involved in the proliferative changes in this patient.- - - - - - - - - - ranking = 1keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
2/12. Peripapillary subretinal neovascularization in sarcoidosis: remission and exacerbation during oral corticosteroid therapy.BACKGROUND: In sarcoidosis, peripapillary subretinal neovascularization is rare. The role of corticosteroid therapy for subretinal neovascularization is controversial. CASE: A 38-year-old female patient weighing 38 kg with histologically diagnosed sarcoidosis presented with peripapillary subretinal neovascularization, retinal phlebitis, a hyperemic disc, and snowball vitreous opacities in the left eye. observation: Oral betamethasone therapy at an initial dose of 3 mg/day reduced the size of subretinal neovascular membrane, and the membrane became fibrous. Despite the total initial 140 mg of betamethasone given over 2.5 months and the additional total 700 mg of prednisolone given over the next 2 months, the subretinal neovascularization recurred. Six months after the first recurrence, a second recurrence developed during the tapering-off period of oral corticosteroid therapy. At the second recurrence, the oral corticosteroid therapy was ineffective in reducing the size of the neovascular membrane. CONCLUSION: In our patient, oral corticosteroids temporarily suppressed peripapillary subretinal neovascularization but failed to prevent extension of neovascular membrane to the fovea because of recurrent sarcoidosis. Over time, oral corticosteroids appear to lose their effectiveness for treating repeated recurrence of peripapillary subretinal neovascularization associated with sarcoidosis.- - - - - - - - - - ranking = 6.8447237217559keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
3/12. Peripheral retinal neovascularization in sarcoidosis.Three black patients with peripheral retinal sea fan neovascularization were found to have sarcoidosis. The periphlebitic process may be the cause of stasis, hypoxia, and a secondary vasoproliferative stimulus. We noted the peculiar finding of a vessel passing through the neovascular tissue into the peripheral retina. This feature may help in the differential diagnosis.- - - - - - - - - - ranking = 2.8430653646438keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
4/12. Proliferative sarcoid retinopathy.sarcoidosis is a well-established cause of ocular neovascularization. A review of the literature, however; shows that it has been implicated as the cause for retinal neovascularization in only a limited number of patients. In this article, the authors report the clinical features of proliferative sarcoid retinopathy in seven additional patients (11 eyes). All 11 eyes displayed retinal neovascularization. In addition, two of the eyes had optic disc neovascularization, whereas iris neovascularization developed in one. In all cases, the new retinal vessels were associated with concomitant peripheral retinal capillary nonperfusion. These findings support the theory that in sarcoidosis, capillary nonperfusion secondary to microvascular shutdown, rather than a direct effect of inflammation, is the stimulus for the formation of retinal neovascularization.- - - - - - - - - - ranking = 2.3689447443512keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
5/12. sarcoidosis and peripheral neovascularization.Twenty-eight patients with sarcoidosis were examined. Four of the patients had a history of uveitis. Retinal periphlebitis was noted in one case, and peripheral retinal neovascularization was found in two non-sickle cell black patients. vitreous hemorrhage developed in one of the patients with neovascularization, prior to laser treatment and this patient eventually required vitreous surgery. The other patient was treated with prophylactic laser. Peripheral retinal neovascularization may be a noteworthy finding that will be found in larger numbers with attention to the retinal periphery in cases of sarcoidosis.- - - - - - - - - - ranking = 1.8948241240585keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
6/12. argon laser treatment of retinal neovascularization associated with sarcoidosis.A 22-year-old Japanese woman with systemic sarcoidosis had retinal neovascularizations at seven loci with repeated vitreous hemorrhage in her right eye. Oral administration of prednisone was not effective. However, argon laser photocoagulation to the neovascularizations obliterated the neovascular fronds except at the optic nerve head; three months from the treatment, the neovascularization at the optic nerve head regressed spontaneously. No serious complications have occurred, and the vitreous hemorrhage has not recurred for the past two years. From these results, argon laser photocoagulation was thought to be effective for the treatment of retinal neovascularization in sarcoidosis.- - - - - - - - - - ranking = 4.3171859849365keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
7/12. sarcoidosis with neovascularization of the optic nerve head.A 25-year-old man with systemic sarcoidosis had neovascularization of the optic nerve heads and associated bilateral vitreous hemorrhages. Oral administration of prednisone produced a prompt resolution of these unusual neovascular fronds and cleared the vitreous hemorrhages.- - - - - - - - - - ranking = 0.52587937970735keywords = neovascularization (Clic here for more details about this article) |
8/12. Peripapillary subretinal neovascularization in presumed sarcoidosis.Peripapillary subretinal neovascularization developed in both eyes of two young women with bilateral chronic granulomatous uveitis. Despite intensive medical therapy, central vision was lost in two eyes owing to disciform scarring that extended to the macula. The neovascularization in the other two eyes was treated successfully with argon laser photocoagulation. Neither of the patients had the clinical or roentgenographic findings typical of sarcoidosis. Both, however, showed elevated serum angiotensin-converting enzyme activity, which provides indirect evidence for the diagnosis of sarcoid uveitis.- - - - - - - - - - ranking = 3.5275377368194keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
9/12. optic nerve sarcoidosis: a report of three cases.Three cases are reported of sarcoidosis, confirmed by a positive Kveim-Silzbach test, presenting with optic nerve swelling. One case subsequently developed gross peripheral retinal ischaemia. Two cases developed peripapillary disciform lesions, with subretinal neovascularization.- - - - - - - - - - ranking = 0.68447237217559keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
10/12. Peripheral retinal neovascularization in sarcoidosis with thalassemia.A black youth with peripheral retinal (sea fan) neovascularization had both sarcoidosis and alpha-thalassemia. The possibility that both of these disease entities were responsible for the observed pathology is explored. Most of the pathology present, the stasis, the hypoxia, and the vasoproliferation, is presumed to be due to the sarcoidosis. No definite relationship was established in this case for the alpha-thalassemia, a rare genetic abnormality of hemoglobin production.- - - - - - - - - - ranking = 2.8430653646438keywords = retinal neovascularization, neovascularization (Clic here for more details about this article) |
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